| Project/Area Number |
22610011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | Oita University |
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Principal Investigator |
SAKAI Kumiko 大分大学, 全学研究推進機構, 助教 (60225753)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Kenji 九州大学, 農学部, 教授 (50205704)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 情動障害 / モノアミンオキシダーゼ / 安息香酸亜鉛 / 脂肪酸 / 環境化学物質 / n-3/n-6脂肪酸 / MAOA |
|---|
| Research Abstract |
Recently, children with learning disabilities and affective disorder are increasing.We previously reportedthat zinc benzoate, a contaminating environmentalcompound, inhibited A-type monoamine oxidase (MAOA). In this report, we investigated how zinc and zinc benzoate influenced activity of MAOA. Microarrayanalysis of brain tissues isolated from mice fed zinc, zinc benzoate or sodium benzoate diets revealed that the regulation of genes involved calcium signal transduction and neuroactive ligand-receptor interactionwere changed.
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