| Project/Area Number |
22610026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
AMASAKI Yoshiko 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 研究員 (80435700)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKINUMA Shizuko 独立行政法人放射線医学総合研究所, 放射線防護研究センター, チームリーダー (20392219)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 思春期 / 放射線 / 胸腺リンパ腫 / 複合曝露 / がん / 環境 / Ikaros |
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| Research Abstract |
We clarified the combined effect of chemical carcinogen treatment with radiation exposure in adolescence, focusing on the effect of the interval between the exposures. We observed the incidence of thymic lymphoma was almost 100% when intervening interval was zero or two weeks. But it decreased significantly when the interval was four or eight weeks. The mutation spectrum of Ikaros (tumor suppressor gene) in the lymphomas was different between the different interval groups. These results suggested that the carcinogenic mechanism of combined exposures varies, depending on the timing of the exposures.
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