Development of the real- time radiation exposure quantity measurement system of body installation type

• Project/Area Number: 22611002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: Tohoku University
• Principal Investigator: HOSOKAI Yoshiyuki 東北大学, 大学院・医学系研究科, 助教 (90451525)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 照射線量 / 人工ルビー / フォトンカウンタ / 光ファイバー / リアルタイム / 放射線治療 / 治療計画 / X 線線量計 / 被曝 / 深部線量計 / 計測システム / X線線量計

Research Abstract

Medical accidents which are over and/or under dose of the irradiation mistake occur frequently in radiation therapy. To reduce these accidents and to increase accuracy of radiation therapy, we are developing an implantable real time mycrodosimetly system. Artificial ruby which is implanted in the patient body/or tumor generates scintillation during the irradiation is used as a sensor. And the doses of radiation are monitored by measuring the intensity of scintillation using photon counting system. As a first step, we made a miniaturized measurement system that is involves scintillator, pig meat as a phantom and measurement instruments. We got the scintillating data that through a thickness of 10cm pig meet, 694nm of scintillation is proportionally generated from artificial ruby scintillators when the LINAC is working at the dose rate of 6Gy/min. We used a 3D-CT image to quantify like an attenuation correction method of the nuclear medicine.

Research Products

• [Journal Article] Fatal intra-abdominal hemorrhage as a result of avulsion of the gallbladder: a postmortem case report (2013)
  • Author(s): Usui A, Kawasumi Y, Hosokai Y, Saito H, Igari Y, and Funayama M
  • Journal Title: Acta Radiol Sh Rep Volume: 2 Issue: 2 Pages: 1-3
  • DOI: 10.1177/2047981613482898
  • Peer Reviewed
• [Journal Article] Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study (2013)
  • Author(s): Akio Kikuchi, Toru Baba, Takafumi Hasegawa, Michiko Kobayashi, Naoto Sugeno, Masatoshi Konno, Emiko Miura, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yoshiyuki Nishio, Kazumi Hirayama, Kyoko Suzuki, Masashi Aoki, ShokiTakahashi, Hiroshi Fukuda, Yasuto Itoyama, Etsuro Mori, Atsushi Takeda
  • Journal Title: BMJ Open Volume: 3 Issue: 3 Pages: e002249-e002249
  • DOI: 10.1136/bmjopen-2012-002249
  • Peer Reviewed
• [Journal Article] Post-mortem computed tomography findings (2013)
  • Author(s): Kawasumi Y, Usui A, Hosokai Y, Sato M, Funayama M, Heat haematoma
  • Journal Title: Clinical Radiol Volume: Vol 68(2)
  • Peer Reviewed
• [Journal Article] Hypothermic death: possibility of diagnosis by post-mortem computed tomography (2013)
  • Author(s): Kawasumi Y
  • Journal Title: Eur J Radiol. Volume: 82 Issue: 2 Pages: 361-365
  • DOI: 10.1016/j.ejrad.2012.11.017
  • Peer Reviewed
• [Journal Article] 技術学会3D・4Dのフロンティア-理想とするAiを目指して (2012)
  • Author(s): 細貝良行,臼井章仁,川住祐介,齋藤春夫,舟山真人
  • Journal Title: 日本放射線技術学会雑誌 Volume: Vol.68 No.12 Pages: 1681-1687
  • NAID: 10031131896
  • URL: http://ci.nii.ac.jp/naid/40019547256
  • Peer Reviewed
• [Journal Article] Cardiac output obtained from test bolus injections as a factor in contrast injection rate revision of following coronary CT angiography (2012)
  • Author(s): Masahiko Konno, Yoshiyuki Hosokai, Akihito Usui, Mitsuya Abe, Toshiki Tateishi, Yusuke Kawasumi, Masashi Tsuda, Hideki Ota, Kei Takase, Haruo Saito
  • Journal Title: Acta Radiologica Volume: 53 Issue: 10 Pages: 1107-11
  • DOI: 10.1258/ar.2012.120276
  • Peer Reviewed
• [Journal Article] Assessment of the relationship between drowning and fluid accumulation in the paranasal sinuses on post-mortem computed tomography (2012)
  • Author(s): Kawasumi Y
  • Journal Title: Eur J Radiol. Volume: 81 Issue: 12 Pages: 3953-3955
  • DOI: 10.1016/j.ejrad.2012.08.011
  • Peer Reviewed
• [Journal Article] HD-PET搭載 PET/CT 装置を用いた画像再構成条 件の基礎的検討 (2012)
  • Author(s): Yoshiyuki Hosokai, Youhei Mutou, Hayato Odagiri, Yusuke Kawasumi, Akihito Usui and Haruo Saito
  • Journal Title: Bulletin of School of Health Sciences Tohoku University Volume: 21(2) Pages: 87-96
  • NAID: 40019436576
  • Peer Reviewed
• [Journal Article] Usefulness of postmortem computed tomography before forensic autopsy for alerting forensic personnel to tuberculosis infection: Report of two cases (2012)
  • Author(s): Akihito Usui, Yusuke Kawasumi,Yoshiyuki Hosokai, Haruo Saito, Tadashi Ishibashi, Masato Funayama
  • Journal Title: Japanese Journal of Radiology August Volume: Volume 30, Issue 7 Issue: 7 Pages: 612-615
  • DOI: 10.1007/s11604-012-0096-1
  • Peer Reviewed
• [Journal Article] Regional cerebral blood flow and abnormal eating behavior in Prader-Willi syndrome (2012)
  • Author(s): Kaeko Ogura, Toshikatsu Fujii, Nobuhito Abe, Yoshiyuki Hosokai, Mayumi Shinohara, Hiroshi Fukuda, Etsuro Mori
  • Journal Title: Brain & development
  • Peer Reviewed
• [Journal Article] Attentional Set-Shifting Deficit in Parkinson's Disease Is Associated with Prefrontal Dysfunction: An FDG-PET Study (2012)
  • Author(s): Yoichi Sawada, Yoshiyuki Nishio, Kyoko Suzuki, Kazumi Hirayama, Atsushi Takeda, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yasuto Itoyama, Shoki Takahashi, Hiroshi Fukuda, Etsuro Mori
  • Journal Title: PLoS ONE Volume: 7(6) Issue: 6 Pages: e38498-e38498
  • DOI: 10.1371/journal.pone.0038498
  • Peer Reviewed
• [Journal Article] Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease : a 3-year longitudinal study (2012)
  • Author(s): BabaT, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, et al
  • Journal Title: Brain Volume: 135 Issue: 1 Pages: 162-169
  • DOI: 10.1093/brain/awr321
  • Peer Reviewed
• [Journal Article] Synthesis of Gd2O3nanoparticles for MRI contrast agents (2012)
  • Author(s): N Sakai, L Zhu, A Kurokawa, H Takeuchi, S Yano, T Yanoh, N Wada, S. Taira, Y Hosokai, A Usui, Y Machida, H Saito and Y Ichiyanagi
  • Journal Title: Journal of Physics: Conference Series Volume: 352
  • URL: http://iopscience.iop.org/1742-6596/352/1/012008
  • Peer Reviewed
• [Journal Article] Unexpected infant death due to hypoplastic left heart syndrome: A case report (2012)
  • Author(s): Hayashizaki Y, Usui K, Moriya T, Hashiyada M, Usui A, Hosokai Y, Kawasumi Y, Saito H, Funayama M
  • Journal Title: Legal Medicine Volume: 13(6) Pages: 293-7
  • Peer Reviewed
• [Journal Article] Association of olfactory dysfunction and brain metabolism in Parkinson's disease (2011)
  • Author(s): Baba T, Takeda A, Kikuchi A, Hishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, et al
  • Journal Title: Movement disorder Volume: 26 Issue: 4 Pages: 621-628
  • DOI: 10.1002/mds.23602
  • Peer Reviewed
• [Journal Article] Illusory misidentifications and cortical hypometabolism in Parkinson's disease (2011)
  • Author(s): Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, et al
  • Journal Title: Movement disorder Volume: 26 Issue: 5 Pages: 837-843
  • DOI: 10.1002/mds.23576
  • Peer Reviewed
• [Journal Article] Small gray matter volume in orbitofrontal cortex in Prader-Willi syndrome: A voxel-based MRI study (2011)
  • Author(s): Kaeko Ogura, Toshikatsu Fujii, Nobuhito Abe, Yoshiyuki Hosokai, Mayumi Shinohara, Shoki Takahashi and Etsuro Mori
  • Journal Title: Hum Brain Mapp Volume: 32 Issue: 7 Pages: 1059-1066
  • DOI: 10.1002/hbm.21089
  • Peer Reviewed
• [Journal Article] 卵巣癌に対するS-1およびL-OHPの抗腫瘍効果の比較検討 (2010)
  • Author(s): 地元佑輔,仲田栄子,駒村一樹,長澤陽介,渡邊重明,齋藤春夫,森一生,田村元,町田好男,石橋忠司,千田浩一,志田原美保,小山内実,小倉隆英,細貝良行,川住祐介,土橋卓,高井良尋
  • Journal Title: Bulletin of School of Health Sciences Tohoku University Volume: 19(2) Pages: 107-115
  • NAID: 120002470921
  • URL: http://mol.medicalonline.jp/library/journal/download?GoodsID=dv0tohih/2010/001902/005&name=0107-0115j&UserID=130.34.173.69&base=jamas_pdf
  • Peer Reviewed
• [Presentation] 東北大学Aiセンターにおける現状とAiに関する疑問点 (2013)
  • Author(s): 細貝良行 川住祐介 臼井章仁 齋藤春夫 舟山眞人
  • Organizer: 第10回Ai学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2013-02-09
• [Presentation] 法 医解剖前CTによる腐敗した脳評価 (2013)
  • Author(s): 臼井章仁 川住祐介 細貝良行 齋藤春夫 中島彩 安孫子絹太 舟山眞人
  • Organizer: 第10回Ai学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2013-02-09
• [Presentation] 法医解剖前CTにおける骨盤周辺部の性差について (2013)
  • Author(s): 安孫子絹太 臼井章仁 細貝良行 川住祐介 中島彩 齋藤春夫 境純 舟山眞人
  • Organizer: 第10回Ai学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2013-02-09
• [Presentation] Postmortem Computed Tomography Finding of Lungs in Sudden Infant Death (2013)
  • Author(s): Kawasumi Y, Usui A, Hosokai Y, Saio M, Nakajima A, Abiko K, Takane Y, Hayashizaki Y, Funayama M
  • Organizer: European Congress of Radiology 2012
  • Place of Presentation: Vienna, Austria
• [Presentation] The association between lumbar rib and lumbosacral transitional vertebrae (2013)
  • Author(s): Nakajima A, Usui A, Hosokai Y, Kawasumi Y, Abiko K, Saito H, Funayama M
  • Organizer: European Congress of Radiology 2012
  • Place of Presentation: Vienna, Austria
• [Presentation] 放射線技師の業務拡大について (2012)
  • Author(s): 細貝良行
  • Organizer: 宮城県放射線技師会招待講演
  • Place of Presentation: 仙台
  • Year and Date: 2012-12-01
• [Presentation] 椎体レベル同定の正確性向上を目的とした腰仙部移行椎と腰肋の発生頻度 (2012)
  • Author(s): 中島彩、臼井章仁、細貝良行、市川真梨亜、稲辺麻衣、脇是孝、齋藤春夫
  • Organizer: 第40回日本放射線技術学会秋季大会
  • Place of Presentation: 東京
• [Presentation] 法医解剖前画像診断における肺所見の有用性 (2012)
  • Author(s): 臼井章仁、川住祐介、林崎義映、細貝良行、佐藤美帆、齋藤春夫、境純、舟山眞人
  • Organizer: 第96次日本法医学会学術全国集会
  • Place of Presentation: 浜松
• [Presentation] 東北大学における法医解剖前画像診断 (2012)
  • Author(s): 林崎義映、舟山眞人、川住祐介、臼井章仁、細貝良行、佐藤美帆、境純、臼井聖尊、橋谷田真樹、齋藤春夫
  • Organizer: 第96次日本法医学会学術全国集会
  • Place of Presentation: 浜松
• [Presentation] Death due to Hypothermia: Postmortem Forensic Computed Tomography (2012)
  • Author(s): Kawasumi Y, Hosokai Y, Usui A, Sato M,Takane Y, Saito H, Ishibashi T, Funayama M
  • Organizer: European Congress of Radiology 2011
  • Place of Presentation: Vienna, Austria
• [Presentation] 法医解剖前CT検査が剖検従事者の結核感染予防に有用であった2例 (2011)
  • Author(s): 臼井章仁、川住祐介、齋藤春夫、細貝良行、林崎義映、境純、大久保愉一、佐藤美帆、石橋忠明、舟山眞人
  • Organizer: 第8回Ai学会学術総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-02-05
• [Presentation] もう一度フィルタについて考えてみよう (2011)
  • Author(s): 細貝良行
  • Organizer: 日本核医学技術学会第17回東北地方会総会学術大会
  • Place of Presentation: 仙台
• [Presentation] What Information in Postmortem Computed Tomography should Radiologist Provide to Forensic Doctor? (2011)
  • Author(s): Kawasumi Y, Hosokai Y, Usui A, Sato M, Takane Y, Saito H, Ishibashi T, Funayama M
  • Organizer: European Congress of Radiology
  • Place of Presentation: Vienna, Austria
• [Presentation] Vertebral Injuries: Postmortem Computed Tomography (2011)
  • Author(s): Kawasumi Y, Hosokai Y, Usui A, Sato M, Takane Y, Saito H, Ishibashi T, Funayama M
  • Organizer: European Congress of Radiology 2010
  • Place of Presentation: Vienna, Austria
• [Presentation] Distinct Longitudinal Differences of Cerebral Glucose Metabolism in Parkinsons Disease with and without Mild Cognitive Impairment: A Longitudinal Study (2010)
  • Author(s): Yoshiyuki H, Akihito U, Haruo S, Yusuke K, Yoshiyuki N, Etsuro M, Yasuto I, Shoki T, Hiroshi F
  • Organizer: Radiological Society of North America 2010 (RSNA)
  • Place of Presentation: Chicago, USA
• [Presentation] A longitudinalstudy of cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment (2010)
  • Author(s): Yoshiyuki H, Akihito U, Haruo S, Yusuke K, Yoshiyuki N, Etsuro M, Yasuto I, Shoki T, Hiroshi F
  • Organizer: World Federation of Nuclear Medicine and Biology 2010
  • Place of Presentation: Cape Town, South Africa
• [Patent(Industrial Property Rights)] 放射線量測定システムおよび放射線量測定方法 (2012)
  • Inventor(s): 細貝良行
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2012-048673
  • Filing Date: 2012-03-06