Research and development for accurate calculation method of monitor unit for proton therapy

• Project/Area Number: 22611004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: University of Tsukuba
• Principal Investigator: TAKADA Yoshihisa 筑波大学, 数理物質系, 教授 (00134205)
• Co-Investigator(Kenkyū-buntansha): KOHNO Ryosuke 独立行政法人国立がん研究センター, 粒子線医学開発部, 研究員 (20392227)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 陽子線治療 / 照射技術 / モニターユニット / 線量校正 / 線量計算 / 簡易モンテカルロ法 / 照射野サイズ補正 / 線量計測

Research Abstract

We have developed a calculation method of monitor units for proton therapy as a product of a factor related to measured data of a part of beam delivery condition (beam energy, SOBP width, range shift) and the other factor related to patient-specific condition calculated by a simplified Monte Carlo calculation. We found effectiveness of the method by showing that it reproduces the measured data within a maximum error of 1.6% for 32 different irradiations to prostate carcinoma treated by proton beam.

Research Products

• [Journal Article] Improvement of spread-out Bragg peak flatness for a carbon-ion beam by the use of a ridge filter with a ripple filter (2012)
  • Author(s): Y. Hara, Y. Takada, et al.
  • Journal Title: Phys. Med. Biol Volume: 57 Pages: 1717-1731
  • URL: http://dx.doi.org/10.1088/0031-9155/57/6/1717
  • Peer Reviewed
• [Journal Article] Improvement of spread-out Bragg peak flatness for a carbon-ion beam by the use of a ridge filter with a ripple filter (2012)
  • Author(s): Y.Hara, Y.Takada, 他10名
  • Journal Title: Phys. Med. Biol. Volume: 57 Issue: 6 Pages: 1717-1731
  • DOI: 10.1088/0031-9155/57/6/1717
  • Peer Reviewed
• [Journal Article] Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional measurements in an anthropomorphic phantom (2010)
  • Author(s): K. Hotta, R. Kohno, Y. Takada, et al.
  • Journal Title: Phys. Med. Biol Volume: 55 Pages: 3545-3556
  • NAID: 120007138093
  • URL: http://dx.doi.org/10.1088/0031-9155/55/12/018
  • Peer Reviewed
• [Journal Article] Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional me asurements in an anthropomorphic phantom. (2010)
  • Author(s): K Hotta, R Kohno, Y Takada, 他7名
  • Journal Title: Phys Med Biol Volume: 55 Pages: 3545-3556
  • NAID: 120007138093
  • Peer Reviewed
• [Presentation] 陽子線治療用bi-material bolusの最適設計法の研 究 (2012)
  • Author(s): 河合竜一、高田義久、他3名
  • Organizer: 第104回日本医学物理学会学術大会
  • Place of Presentation: つくば
• [Presentation] ワブラー法における入射ビームモデルの改善と簡易モンテカルロ法を使った線量分布計算の精度検証 (2012)
  • Author(s): 丹正亮平,河野良介,高田義久,他4名
  • Organizer: 第104回日本医学物理学会学術大会
  • Place of Presentation: つくば
• [Presentation] Dose Calculation Model Using the Simplified Monte Carlo Method with an Initial Beam Model Adapted to a Beam‐Wobbling System (2012)
  • Author(s): R. Tansho, R. Kohno, Y. Takada, et al.
  • Organizer: Proc. of the 55th Annual Meeting of the AAPM
  • Place of Presentation: North Carolina
• [Presentation] Improved Calculation Accuracy of Monitor Units with Aperture Correction for Proton Radiotherapy (2012)
  • Author(s): Y. Takada, K. Nagafuchi, K. Hotta, R. Kohno, et al
  • Organizer: Abstract book of the 51-th PTCOGscientific meeting
  • Place of Presentation: Coex, in Seoul
• [Presentation] Improved Calculation Accuracy of Monitor Units with Aperture Correction for Proton Radiotherapy (2012)
  • Author(s): Y. Takada, K. Nagafuchi, K. Hotta, R. Kohno ,他3名
  • Organizer: 51-th PTCOG scientific meeting
  • Place of Presentation: Coex, in Souel, Korea
• [Presentation] Dose Calculation Model Using the Simplified Monte Carlo Method with an Initial Beam Model Adapted to a Beam‐Wobbling System (2012)
  • Author(s): R Hansho, Y. Takada, R. Kohn, K. Hotta, 他4名
  • Organizer: 55th Annual Meeting of the AAPM
  • Place of Presentation: North Carolina, USA
• [Presentation] ワブラー法における入射ビームモデルの改善と簡易モンテカルロ法を使った線量分布計算の精度検証 (2012)
  • Author(s): 丹正亮平、河野良介、高田義久、他4名
  • Organizer: 第104回日本医学物理学会学術大会
  • Place of Presentation: つくば国際会議場, つくば市
• [Presentation] 陽子線治療用bi-material bolusの最適設計法の研究 (2012)
  • Author(s): 河合竜一、高田義久、他３名
  • Organizer: 第104回日本医学物理学会学術大会
  • Place of Presentation: つくば国際会議場, つくば市
• [Presentation] Dose calculation model using the Simplified Monte Carlo method applied to the beam-wobbling system at NCCHE (2011)
  • Author(s): R.Tansho, R.Kohno, Y.Takada, 他5名
  • Organizer: The 6^<th> Japan- Korea Joint Meeting on Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka, Japan
  • Year and Date: 2011-10-01
• [Presentation] Calculation of monitor units for proton radiotherapy (2011)
  • Author(s): K.Nagafuchi, Y.Takada, R.Kohno, 他4名
  • Organizer: The 6^<th> Japan-Korea Joint Meeting on Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka, Japan
  • Year and Date: 2011-09-30
• [Presentation] Design method of range compensators based on dose optimization (2011)
  • Author(s): Y.Takada, T.Nihei, 他3名
  • Organizer: The 6^<th> Japan-Korea Joint Meeting on Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka, Japan
  • Year and Date: 2011-09-30
• [Presentation] Calculation of monitor units for proton radiotherapy (2011)
  • Author(s): K. Nagafuchi, Y. Takada, et al.
  • Organizer: Proc. of the 6th Japan- Korea Joint Meeting on Medical Physics
  • Place of Presentation: Fukuoka
• [Presentation] Dose calculation model using the Simplified Monte Carlo method applied to the beam-wobbling system at NCCHE (2011)
  • Author(s): R. Tansho, R. Kohno, Y. Takada, et al.
  • Organizer: Proc. of the 6th Japan- Korea Joint Meeting on Medical Physics
  • Place of Presentation: Fukuoka
• [Presentation] Design method of range compensators based on dose optimization (2011)
  • Author(s): Y. Takada, T. Nihei, et al.
  • Organizer: Proc. of the 6th Japan- Korea Joint Meeting on Medical Physics
  • Place of Presentation: Fukuoka
• [Presentation] Comparison of Dose Distributions Between Two Arrangements of a Range Compensator and of An Aperture Collimator in a Passive Scattering Method for Proton Therapy (2011)
  • Author(s): K. Hotta, R. Kohno, Y. Takada, et al.
  • Organizer: Proc. of the 53th Annual Meeting of the AAPM
  • Place of Presentation: Vancouver
• [Presentation] A novel design method of range compensators based on dose optimization inside around the target (2011)
  • Author(s): Y. Takada, T. Nihei, et al.
  • Organizer: Abstract book of Posters of the PTCOG50
  • Place of Presentation: Pennsylvania
• [Presentation] SOBP formation of a carbon-ion beam using a ridge filter with a ripple filter on the same frame (2011)
  • Author(s): Y. Hara, Y. Takada, et al
  • Organizer: Abstract book of posters of the PTCOG50
  • Place of Presentation: Pennsylvania
• [Presentation] Dose calculation model using the Simplified-Monte-Carlo method based on an accurate incident-beam model for the beam-wobbling system at NCCHE (2011)
  • Author(s): R. Tansho, R. Kohno, Y. Takada, et al
  • Organizer: Abstract book of posters of the PTCOG5
  • Place of Presentation: Pennsylvania
• [Presentation] Alスラブ通過後の単一エネルギー炭素線のブラッグピーク形状のスラブ厚依存性 (2011)
  • Author(s): 原洋介, 高田義久, 他6名
  • Organizer: 第101回日本医学物理学会学術大会
  • Place of Presentation: 東京
• [Presentation] A novel design method of range compensators based on dose optimization inside around the target (2011)
  • Author(s): Y.Takada, T.Nihei, 他3名
  • Organizer: The 50^<th> Particle Therapy Cooperative Group Meeting
  • Place of Presentation: Pennsylvania, USA
• [Presentation] SOBP formation of a carbon-ion beam using a ridge filter with a ripple filter on the same frame (2011)
  • Author(s): Y.Hara, Y.Takada, 他6名
  • Organizer: The 50^<th> Particle Therapy Cooperative Group Meeting
  • Place of Presentation: Pennsylvania, USA
• [Presentation] Dose calculation model using the Simplified-Monte-Carlo method based on an accurate incident-beam model for the beam-wobbling system at NCCHE (2011)
  • Author(s): R.Tansho, R.Kohno, Y.Takada, 他5名
  • Organizer: The 50^<th> Particle Therapy Cooperative Group Meeting
  • Place of Presentation: Pennsylvania, USA
• [Presentation] Comparison of Dose Distributions Between Two Arrangements of a Range Compensator and of An Aperture Collimator in a Passive Scattering Method for Proton Therapy (2011)
  • Author(s): K.Hotta, R.Kohno, Y.Takada, 他5名
  • Organizer: The 53th Annual Meeting of the AAPM
  • Place of Presentation: Vancouver, Canada
• [Presentation] Dose calculation model using the Simplified Monte Carlo method applied to the beam-wobbling system at NCCHE (2011)
  • Author(s): 原洋介、高田義久, 他6名
  • Organizer: 第101回日本医学物理学会学術大会
  • Place of Presentation: 東京(震災によりWeb上で開催)
• [Presentation] 陽子線治療における計算による線量較正値の算 (2010)
  • Author(s): 永渕功輔, 高田義久, 他6名
  • Organizer: 第100回日本医学物理学会学術大会
  • Place of Presentation: 東京
• [Presentation] Ripple filterを用いた炭素イオン線によるSOBP形成の改善 (2010)
  • Author(s): 原洋介, 高田義久, 他6名
  • Organizer: 第100回日本医学物理学会学術大会
  • Place of Presentation: 東京
• [Presentation] 陽子線のコリメータエッジ散乱に対する入射エネルギーの影響 (2010)
  • Author(s): 丹正亮平, 高田義久, 他4名
  • Organizer: 第71回応用物理学関係連合講演会
  • Place of Presentation: 長崎
• [Presentation] A retrospective analysis in head and neck cancer by using the simplified Monte Carlo algorithm (2010)
  • Author(s): K. Hotta, R. Kohno, Y. Takada , et al.
  • Organizer: Proc. of the 52th Annual Meeting of the AAPM
  • Place of Presentation: Pennsylvania
• [Presentation] Improvement of beam-use efficiency for double-scattering method using a multiple-ring second scatterer in proton therapy (2010)
  • Author(s): Y. Takada, K. Hotta, R. Kohno, et al.
  • Organizer: Abstract book of the PTCOG49
  • Place of Presentation: Maebashi
• [Presentation] Conceptual design of a novel ridge filter with a ripple filter for improvement of SOBP for carbon-ion therapy (2010)
  • Author(s): Y. Hara, Y. Takada, et al
  • Organizer: Abstract book of the PTCOG49
  • Place of Presentation: Maebashi
• [Presentation] Effect of range-compensator thickness on proton scattering in an aperture collimator (2010)
  • Author(s): R. Tansho, Y. Takada, et al.
  • Organizer: Abstract book of the PTCOG49
  • Place of Presentation: Maebashi
• [Presentation] Effect of range-compensator thickness on proton scattering in an aperture collimator. (2010)
  • Author(s): R Tansho, Y Takada, 他6名
  • Organizer: The 50^<th> Particle Therapy Cooperative Group Meeting
  • Place of Presentation: Green Dome Maebashi, Gunma, Japan
• [Presentation] 陽子線治療における計算による線量較正値の算出 (2010)
  • Author(s): 永渕功輔、高田義久, 他6名
  • Organizer: 第100回日本医学物理学会学術大会
  • Place of Presentation: 学術総合センター,東京・一ツ橋
• [Presentation] 陽子線のコリメータエッジ散乱に対する入射エネルギーの影響 (2010)
  • Author(s): 丹正亮平、高田義久, 他4名
  • Organizer: 第71回応用物理学会学術講演会
  • Place of Presentation: 長崎大学文教キャンパス長崎
• [Remarks]
  • URL: http://taklabo.bk.tsukuba.ac.jp/~takadalabo/