Development of high precision 3D radiation treatment planning system based on similar cases

• Project/Area Number: 22611011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: Kyushu University
• Principal Investigator: ARIMURA Hidetaka 九州大学, 医学研究院, 保健学部門 (20287353)
• Co-Investigator(Kenkyū-buntansha): 中村 和正 九州大学, 大学病院, 准教授 (20284507) ; 塩山 善之 九州大学, 医学(系)研究科(研究院), 教授 (10323304)
• Co-Investigator(Renkei-kenkyūsha): 塩山 善之 九州大学, 医学研究院, 教授 (10323304)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 治療計画 / 類似症例検索 / 画像処理 / 放射線治療 / 類似症例 / 放射線治療計画 / 画像特徴量 / 高精度放射線治療 / 計画症例自動検索 / 医用画像処理 / 自動画像検索

Research Abstract

The purpose of this study was to develop a computer-aided method for determination of beam arrangements based on similar cases in a radiotherapy treatment-planning database for stereotactic lung radiation therapy. First, the five most similar cases were searched, based on geometrical features related to the location, size and shape of the planning target volume, lung and spinal cord. Second, five beam arrangements of an objective case were automatically determined by registering five similar cases with the objective case, with respect to lung regions, by means of a linear registration technique. The most usable beam arrangement was selected by sorting the five treatment plans based on eight plan evaluation indices, including the D95, mean lung dose and spinal cord maximum dose. We applied the proposed method to 10 test cases, by using an RTPdatabase of 81 cases with lung cancer, and compared the eight plan evaluation indices between the original treatment plan and the corresponding most usable similar-case-based treatment plan. As a result, the proposed method may provide usable beam arrangements, which have no statistically significant differences from the original beam arrangements (P > 0.05) in terms of the eight plan evaluation indices. Therefore, the proposed method could be employed as an educational tool for less experienced treatment planners.

Research Products

• [Journal Article] 豊福不可依,放射線治療におけるelectronic portal imaging device を用いた4次元線量分布推定法の開発 (2013)
  • Author(s): 溝口明日実, 有村秀孝, 塩山善之, 廣瀬貴章, 穴井重男, 本田浩, 梅津芳幸, 平田秀紀, 大喜雅文, 中村和正
  • Journal Title: 電子情報通信学会 医用画像特集 Volume: Vol.J96-D,No.4 Pages: 813-823
  • Peer Reviewed
• [Journal Article] Computer-aided beam arrangement based on similar cases in radiation treatment planning databases for stereotactic lung radiation therapy. (2013)
  • Author(s): Magome T, Arimura H, Shioyama Y, Mizoguchi A, Tokunaga C, Nakamura K, Honda H, Ohki M, Toyofuku F, Hirata H.
  • Journal Title: Journal of Radiation Research Volume: Vol. 54
  • Peer Reviewed
• [Journal Article] Computer-aided beam arrangement based on similar cases in radiation treatment planning databases for stereotactic lung radiation therapy. (2013)
  • Author(s): Magome T, Arimura H, et al.
  • Journal Title: Journal of Radiation Research Volume: (In press) Issue: 3 Pages: 569-577
  • DOI: 10.1093/jrr/rrs123
  • Peer Reviewed
• [Journal Article] 放射線治療におけるelectronic portal imaging deviceを用いた4次元線量分布推定法の開発 (2013)
  • Author(s): 溝口明日実, 有村秀孝, 他
  • Journal Title: 電子情報通信学会和文論文誌 Volume: Vol.J96-D,No.4 Pages: 813-823
  • Peer Reviewed
• [Journal Article] Computerized estimation of patient setup errors in portal images based on localized pelvic templates for prostate cancer radiotherapy (2012)
  • Author(s): Arimura H, Itano W, Shioyama Y, Matsushita N, Magome T, Yoshitake T, Anai S, Nakamura K, Yo s hid o me S, Yamagami A, Honda H, Ohki M, Toyofuku F, Hirata H.
  • Journal Title: Journal of Radiation Research Volume: 53(6) Pages: 961-72
  • Peer Reviewed
• [Journal Article] Hayabuchi N.,Automated Estimation of Number of Implanted Iodine-125 Seeds for Prostate Brachytherapy based on Two-View Analysis of Pelvic Radiographs (2012)
  • Author(s): Kawata H, Arimura H, Suefuji H, Ohkura S, Saida Y, Nashiki K, Hayashida K, Kawahara T, Ohishi A
  • Journal Title: Journal of Radiation Research Volume: 53(5) Pages: 742-52
  • Peer Reviewed
• [Journal Article] Esophageal Stenosis Associated with Tumor Regression in Radiation Therapy for Esophageal Cancer:Frequency and Prediction (2012)
  • Author(s): Atsumi K, Shioyama Y, Arimura H, Terashima K, Matsuki T, Ohga S, Yoshitake T, Nonoshita T, Tsurumaru D, Ohnishi K, Asai K, Matsumoto K, Nakamura K, Honda H.
  • Journal Title: International Journal of Radiation Oncology, Biology, Physics Volume: 82(5) Pages: 1973-80
  • Peer Reviewed
• [Journal Article] Computerized estimation of patient setup errors in portal images based on localized pelvic templates for prostate cancer radiotherapy (2012)
  • Author(s): Arimura H, Itano W, et al.
  • Journal Title: Journal of Radiation Research Volume: 53(6) Issue: 6 Pages: 961-972
  • DOI: 10.1093/jrr/rrs043
  • Peer Reviewed
• [Journal Article] Automated estimation of number of implanted iodine-125 seeds for prostate brachytherapy based on two-view analysis of pelvicradiographs. (2012)
  • Author(s): Kawata H, Arimura H, Suefuji H, Ohkura S, Saida Y, Nashiki K, Hayashida K, Kawahara T, Ohishi A,Hayabuchi N.
  • Journal Title: J Radiat Res Volume: 53(5) Issue: 5 Pages: 742-752
  • DOI: 10.1093/jrr/rrs018
  • Peer Reviewed
• [Journal Article] Estimation of focal and extra-focal radiation profiles based on Gaussian modeling in medical linear accelerators (2011)
  • Author(s): Anai S, Arimura H, Nakamura K, Ar aki F, Matsuki T, Yoshikawa H, Yoshidome S, Shioyama Y, Honda H, Ikeda N.
  • Journal Title: Radiological Physics and Technology Volume: 4(2) Pages: 173-9
  • Peer Reviewed
• [Journal Article] 肺定位放射線治療におけるEPIDシネ画像を用いた腫瘍位置のずれ量自動推定方法の開発 (2011)
  • Author(s): 吉留 郷志, 有村 秀孝, 塩山 善之, 中村和正, 穴井重男, 中村浩太, 野元諭, 本田 浩, 豊福不可依, 寺嶋廣美, 平田秀紀
  • Journal Title: 医学物理 Volume: Vol.30, No.3 Pages: 120-131
  • NAID: 130005117982
  • Peer Reviewed
• [Journal Article] Automated Detection of Multiple Sclerosis Candidate Regions in MR Images : False-Positive Removal with Use of an ANN-controlled Level Set Method (2011)
  • Author(s): Kuwazuru J, Arimura H, Kakeda S, et.al.
  • Journal Title: Radiological Physics and Technology Volume: 5 Pages: 105-113
  • Peer Reviewed
• [Journal Article] MR脳血流マップ画像を用いたアルツハイマー病の鑑別支援システムの開発 (2011)
  • Author(s): 山下泰生, 有村秀孝, 吉浦敬, 他
  • Journal Title: 医用画像情報学会雑誌 Volume: 28 Pages: 72-78
  • NAID: 130001206625
  • Peer Reviewed
• [Journal Article] Automated determination of beam arrangement based on similar cases in radiotherapy treatment planning database for lung stereotactic body radiotherapy (2011)
  • Author(s): Magome T, Arimura H, et al
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 81
• [Journal Article] Estimation of focal and extra-focal radiation profiles based on Gaussian modeling in medical linear accelerators (2011)
  • Author(s): Anai S, Arimura H, Nakamura K., et.al.
  • Journal Title: Radiological Physics and Technology Volume: (印刷中 accepted)
  • Peer Reviewed
• [Journal Article] Esophageal Stenosis Associated with Tumor Regression in Radiation Therapy for Esophageal Cancer : Frequency and Prediction (2011)
  • Author(s): Atsumi K, Shioyama Y, Arimura H, et.al.
  • Journal Title: International Journal of Radiation Oncology, Biology, Physics Volume: (印刷中 accepted)
  • Peer Reviewed
• [Journal Article] 肺定位放射線治療におけるEPIDシネ画像を用いた腫瘍位置のずれ量自動推定方法の開発 (2011)
  • Author(s): 吉留郷志, 有村秀孝, 塩山善之, 他
  • Journal Title: 医学物理 Volume: 30(3) Pages: 120-131
  • NAID: 130005117982
  • Peer Reviewed
• [Presentation] Optimization method of beam directions based on similar cases in stereotactic body radiotherapy for lung cancers (2013)
  • Author(s): Taiki Magome, Hidetaka Arimura, Yoshiyuki Shioyama, Asumi Mizoguchi, Katsumasa Nakamura, Yasuhiko Nakamura, Hiroshi Honda, Masafumi Ohki, Fukai Toyofuku, Hideki Hirata
  • Organizer: 第105回日本医学物理学会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-04-13
• [Presentation] Computer-Assisted Particle Therapy System Based on Computational Anatomy Models for Treatment Planning (2013)
  • Author(s): Hidetaka Arimura
  • Organizer: Computational Anatomy for Computer-aided Diagnosis and Therapy
  • Place of Presentation: Osaka University
  • Year and Date: 2013-02-23
• [Presentation] 類似症例に基づくビームアングルの最適化方法の開発 (2012)
  • Author(s): 馬込大貴,有村秀孝,塩山善之,溝口明日実,徳永千晶,中村和正,本田浩,中村泰彦,豊福不可依,平田秀紀
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-23
• [Presentation] Computer-assisted determination of the usable beam arrangement from similar treatment plans in stereotactic body radiotherapy (p.101-107),Workshop of Image-Guidance and Multimodal Dose Planning in Radiation Therapy (2012)
  • Author(s): Magome T, Arimura H, Shioyama Y, Mizoguchi A, Tokunaga C, Nakamura K, Nakamura Y, Honda H, Ohki, Toyofuku F, Hirata H.
  • Organizer: MICCAI 2012
  • Place of Presentation: Nice
  • Year and Date: 2012-10-05
• [Presentation] ComputationalImage-Assisted Radiation Treatment Planning (2012)
  • Author(s): Arimura H, Jin Z, Kakiuchi G, Magome T, ShioyamaY, Nakamura K.
  • Organizer: Progress in Radiology 2012
  • Place of Presentation: Tokyo
  • Year and Date: 2012-09-07
• [Presentation] Similar-case-based optimization of beam arrangements in stereotactic body radiation therapy (2012)
  • Author(s): Magome T, Arimura H, Shioyama Y, Mizoguchi A, Tokunaga C, Nakamura K, Honda H, Ohki, Toyofuku F, Hirata H.
  • Organizer: AAPM2012
  • Place of Presentation: Charlott
  • Year and Date: 2012-07-31
• [Presentation] 肺定位放射線治療計画支援のための類似症例に基づくビーム方向自動決定法の開発 (2012)
  • Author(s): 馬込大貴,有村秀孝,塩山善之,溝口明日実,徳永千晶,中村和正,本田 浩,大喜雅文,豊福不可依,平田秀紀
  • Organizer: 第103回日本医学物理学会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-14
• [Presentation] Computer-assisted radiation treatment planning system for determination of beam directions based on similar cases in a database for stereotactic body radiotherapy (2012)
  • Author(s): Magome T, Arimura H, Shioyama Y, Mizoguchi A, Tokunaga C, Nakamura K, Honda H, Ohki M, Toyofuku F, Hirata H.
  • Organizer: SPIE Medical Imaging 2012
  • Place of Presentation: San Diego
  • Year and Date: 2012-02-07
• [Presentation] 放射線治療計画支援のための類似症例を用いたビーム方向決定法の開発 (2012)
  • Author(s): 馬込大貴,有村秀孝,塩山善之,徳永千晶,中村和正,本田 浩,大喜雅文,豊福不可依,平田秀紀
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 2012-01-19
• [Presentation] Automated Contouring of Tumor Regions in CT Images Using an Adaptive Level Set Method (2012)
  • Author(s): Arimura H, Kuwazuru J, Shioyama Y, et al
  • Organizer: IWAIT2012
  • Place of Presentation: Ho Chi Minh City, Vietnam
  • Year and Date: 2012-01-09
• [Presentation] 肺定位放射線治療における類似症例を用いたビームアングルの自動決定法 (2011)
  • Author(s): 馬込大貴,有村秀孝,塩山善之,徳永千晶,中村和正,穴井重男,本田 浩,大喜雅文,豊福不可依,平田秀紀
  • Organizer: 第24回日本放射線腫瘍学会(JASTRO)
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-19
• [Presentation] Automated Determination of Beam Arrangement Based on Similar Cases in Radiotherapy Treatment Planning Database for Lung Stereotactic Body Radiotherapy (2011)
  • Author(s): Magome T, Arimura H, Shioyama Y, Tokunaga C, Nakamura K, Anai S, Honda H, Ohki M, Toyofuku F, Hirata H.
  • Organizer: ASTRO 2011
  • Place of Presentation: Miami Beach
  • Year and Date: 2011-10-05
• [Presentation] Automated Determination of Beam Arrangement Based on Similar Cases in Radiotherapy Treatment Planning Database for Lung Stereotactic Body Radiotherapy (2011)
  • Author(s): Magome T, Arimura H, et al
  • Organizer: ASTRO 54th Annual Meeting
  • Place of Presentation: Miami Beach Convention Center, Miami Beach, USA
  • Year and Date: 2011-10-05
• [Presentation] Automated method for determination of beam directions based on similar cases for lung stereotactic body radiotherapy. (2011)
  • Author(s): Magome T, Arimura H, Shioyama Y, Tokunaga C, Nakamura K, Honda H, Ohki M, Hirata H, Toyofuku F.
  • Organizer: 6th Japan-Korea Joint Meeting on Medical Physics (JKMP), 11th Asia-Oceania Congress of Medical Physics(AOCMP)
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-10-01
• [Presentation] 肺定位放射線治療における肺腫瘍領域線量分布のモニタリング法の開発 (2011)
  • Author(s): 有村秀孝, 溝口明日実, 吉留郷志, 他
  • Organizer: 2011年度電子情報通信学会医用画像研究会
  • Place of Presentation: つくば
  • Year and Date: 2011-09-06
• [Presentation] 医学物理における医用画像処理の役割 (2010)
  • Author(s): 有村秀孝
  • Organizer: 第100回日本医学物理学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-25
• [Presentation] 画像誘導放射線治療を支える医用画像処理技術 (2010)
  • Author(s): 有村秀孝
  • Organizer: 第100回日本医学物理学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-23
• [Presentation] 高精度放射線治療を支える医用画像処理 (2010)
  • Author(s): 有村秀孝
  • Organizer: 第71回応用物理学会学術講演会
  • Place of Presentation: 長崎市
  • Year and Date: 2010-09-14
• [Presentation] Stereotactic Body Radiotherapy : Computer-Assisted Verification of a Lung Tumor Region Using EPID Without Implanted Markers (2010)
  • Author(s): Arimura H, Shioyama Y, Nakamura K, et al.
  • Organizer: American Association of Physicists in Medicine
  • Place of Presentation: Philadelphia
  • Year and Date: 2010-07-18
• [Presentation] State-of-the-art CAD-Brain MR Images (2010)
  • Author(s): Arimura H
  • Organizer: International Conference Medical Biometrics
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-06-30
• [Presentation] Computer-aided verification of a lung tumor location using EPID without implanted markers in stereotactic body radiotherapy (2010)
  • Author(s): Arimura H, Shioyama Y, Nakamura K, et al.
  • Organizer: Computer Assisted Radiology and Surgerya
  • Place of Presentation: Genova
  • Year and Date: 2010-06-23
• [Presentation] Computerized determination of robust beam directions against patient setup errors in hadron particle therapy
  • Author(s): Arimura H, Kakiuchi G, et al.
  • Organizer: Workshop of Image-Guidance and Multimodal Dose Planning in Radiation Therapy, MICCAI 2012
  • Place of Presentation: ニース
• [Presentation] Computer-assisted determination of the usable beam arrangement from similar treatment plans in stereotactic body radiotherapy
  • Author(s): Magome T, Arimura H, et al.
  • Organizer: Workshop of Image-Guidance and Multimodal Dose Planning in Radiation Therapy, MICCAI 2012
  • Place of Presentation: ニース
• [Presentation] Automated Method for Extraction of Lung Tumors Using a Machine Learning Classifier with Knowledge from Radiation Oncologists on Data Sets of Planning CT and FDG-PET/CT images
  • Author(s): Arimura H
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: 大阪
  • Invited
• [Book] Analysis for Assisting Radiation Oncologists' Decision Making in Radiation Treatment Planning," (2013)
  • Author(s): Arimura H, Magome T, Kakiuchi G, Kuwazuru J, Mizoguchi A
  • Total Pages: 30
  • Publisher: The University of Chicago
• [Book] Springer (2013)
  • Author(s): Arimura H, Magome T, et al.
  • Total Pages: 30
  • Publisher: Computational Intelligent Image Analysis for Assisting Radiation Oncologists’ Decision Making in Radiation Treatment Planning
• [Book] "Magnetic Resonance Image Analysis for Brain CAD Systems with Machine Learning in Machine Learning" in Computer-Aided Diagnosis : Medical Imaging Intelligence and Analysis Edited(The University of Chicago)(by Kenji Suzuki) (2012)
  • Author(s): Arimura H, Tokunaga C, Yamashita Y, et al
  • Publisher: IGI Global
• [Book] 医用画像ハンドブック(監修:石田隆行,桂川茂彦,藤田広志)(第1編13章レベルセット法:p274～p279,第4編11章MR画像の画像処理:p936～p942 (2011)
  • Author(s): 有村秀孝(分担執筆)
  • Total Pages: 13
  • Publisher: オーム社
• [Remarks] 研究者のホームページで研究成果を,英語と日本語で以下のURLで公開している.
  • URL: http://www.shs.kyushu-u.ac.jp/~arimura
• [Remarks] 有村秀孝研究室
  • URL: http://web.shs.kyushu-u.ac.jp/~arimura
• [Remarks] 有村秀孝研究室
  • URL: http://web.shs.kyushu-u.ac.jp/~arimura//index.html
• [Remarks] 有村秀孝研究室
  • URL: http://web.shs.kyushu-u.ac.jp/~arimura//index.html
• [Patent(Industrial Property Rights)] 放射線ビームアングル決定システム,放射線ビームアングル決定方法及び放射線ビームアングル決定用コンピュータプログラム (2012)
  • Inventor(s): 有村秀孝,馬込大貴,塩山善之
  • Industrial Property Rights Holder: 九州大学
  • Industrial Property Number: 2012-069606
  • Filing Date: 2012-03-26
• [Patent(Industrial Property Rights)] 放射線ビームアングル決定システム、放射線ビームアングル決定方法及び放射線ビームアングル決定用コンピュータプログラム (2012)
  • Inventor(s): 有村秀孝，馬込大貴，塩山善之
  • Industrial Property Rights Holder: 有村秀孝，馬込大貴，塩山善之
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-04-10
• [Patent(Industrial Property Rights)] 放射線ビームアングル決定システム、放射線ビームアングル決定方法及び放射線ビームアングル決定用コンピュータプログラム (2012)
  • Inventor(s): 有村秀孝, 馬込大貴, 塩山善之
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Number: 2012-069606
  • Filing Date: 2012-03-26
• [Patent(Industrial Property Rights)] 粒子線ビーム方向決定システム、粒子線ビーム方向決定方法及び粒子線ビーム方向決定コンピュータ用プログラム (2012)
  • Inventor(s): 有村秀孝, 垣内玄雄, 塩山善之, 中村和正
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Number: 2012-041569
  • Filing Date: 2012-02-28