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An application of molecular imaging using TOF-PET/CTfor radiation treatment planning

Research Project

Project/Area Number 22611012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical Physics/Radiological Technology
Research InstitutionKyushu University

Principal Investigator

SASAKI Masayuki  九州大学, 医学研究院, 教授 (40240907)

Co-Investigator(Kenkyū-buntansha) HIRATA Hideki  九州大学, 医学研究院, 教授 (70173242)
YABUUCHI Hidetake  九州大学, 医学研究院, 准教授 (70380623)
ARIMURA Hidetaka  九州大学, 医学研究院, 准教授 (20287353)
Co-Investigator(Renkei-kenkyūsha) ABE Koichiro  九州大学, 大学病院, 助教 (00380387)
SHIOYAMA Yoshiyuki  九州大学, 大学病院, 助教 (10323304)
OYA Nobuyoshi  九州大学, 大学病院, 技官 (70380475)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsPET / TOF / 分子イメージング / 放射線治療 / time of flight / 放射線治療計画 / time of fliht
Research Abstract

The purpose of this study is to establish a method for effectively utilizing molecular imaging using time-of-flight (TOF)- PET / CT system for radiation treatment planning. We found that the TOF correction is useful for improving the quantitative and diagnostic performance of PET/CT. We determined the optimal examination conditions, the methods to compensate respiratory motion and the thresholds to extract tumor contour. We developed a program to use PET/CT images to radiation treatment planning and found that it was useful as a support tool for planning.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (39 results)

All 2013 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (32 results)

  • [Journal Article] Benefits of point-spread-function and time-of-flight for PET/CT image quality in relation to the body mass index and injected dose.2013

    • Author(s)
      Akamatsu G, Mitsumoto K, Ishikawa K, Taniguchi T, Ohya N, Baba S, Abe K, Sasaki M.
    • Journal Title

      Clin Nucl Med.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Benefits of point-spread-function and time-of-flight for PET/CT image quality in relation to the body mass index and injected dose.2013

    • Author(s)
      Akamatsu G、他7名.
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 38 Issue: 6 Pages: 407-412

    • DOI

      10.1097/rlu.0b013e31828da3bd

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in PET/CT image quality with a combination of the point-spread-function and time-offlight in relation to the reconstruction parameters.2012

    • Author(s)
      Akamatsu G, Ishikawa K, Mitsumoto K, Taniguchi T, Ohya N, Baba S, Abe K,Sasaki M
    • Journal Title

      J Nucl Med.

      Volume: 53 Pages: 1716-22

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in PET/CT image quality with a combination of the point-spread-function and time-of-flight in relation to the reconstruction parameters2012

    • Author(s)
      Akamatsu G、他7名.
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 3 Issue: 11 Pages: 1716-1722

    • DOI

      10.2967/jnumed.112.103861

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] determination of the optimal acquisition protocol of breath-hold PET/CT for the diagnosis of thoracic lesions.2011

    • Author(s)
      Mitsumoto K, Abe K, Sakaguchi Y, Zhang T, Tachiya Y, Ohya N, Baba S, Sasaki M
    • Journal Title

      Nucl Med Commun.

      Volume: 32 Pages: 1148-54

    • NAID

      120005133068

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring.2010

    • Author(s)
      Zhang T, Tachiya Y, Sakaguchi Y, Mitsumoto K, Mitsumoto T, Ohya N, Sasaki M.
    • Journal Title

      Fukuoka Igaku Zasshi.

      Volume: 101 Pages: 238-246

    • NAID

      120002795244

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring2010

    • Author(s)
      Zhang T, 他6名
    • Journal Title

      Fukuoka Acta Medica

      Volume: 101 Pages: 238-246

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The influences of point-spread-function and time-of-flight on SUV of lymph node metastasis in FDG-PET.2012

    • Author(s)
      Akamatsu G, Mitsumoto K, Taniguchi T, Komiya I, Ohya N, Abe K, Baba S, Sasaki M.
    • Organizer
      59th Annual Meeting, Society of Nuclear Medicine.
    • Place of Presentation
      Miami Beach, Florida, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] FDGのリンパ節集積に対するTOF補正の影響2012

    • Author(s)
      赤松 剛、他5名.
    • Organizer
      第68回 日本放射線技術学会総会学術大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] TOF補正による大口径ファントムのPET/CT画像の画質改善2012

    • Author(s)
      谷口隆文、他5名.
    • Organizer
      第68回 日本放射線技術学会総会学術大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The influences of point-spread-function and time-of-flight on SUV of lymph node metastasis in FDG-PET.2012

    • Author(s)
      Akamatsu G、他7名.
    • Organizer
      第59回 米国核医学会
    • Place of Presentation
      マイアミビーチコンベンションセンター(マイアミビーチ市、米国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of PSF and TOF on the PET/CT image quality at various noise levels.2012

    • Author(s)
      Akamatsu G、他7名.
    • Organizer
      第59回 米国核医学会
    • Place of Presentation
      マイアミビーチコンベンションセンター(マイアミビーチ市、米国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Improvement in PET/CT image quality in a 40 cm-large phantom with PSF and TOF.2012

    • Author(s)
      Taniguchi T、他7名.
    • Organizer
      第59回 米国核医学会
    • Place of Presentation
      マイアミビーチコンベンションセンター(マイアミビーチ市、米国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Improvement in the recovery coefficient of PET/CT images with PSF and TOF.2012

    • Author(s)
      Taniguchi T、他7名.
    • Organizer
      第59回 米国核医学会
    • Place of Presentation
      マイアミビーチコンベンションセンター(マイアミビーチ市、米国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] TOF-PET/CT装置の検出器リング数の違いに関する検討(1) ‐39リング装置と52リング装置の基本性能の違い‐2012

    • Author(s)
      姥 浩二、他9名.
    • Organizer
      第32回 日本核医学技術学会総会学術大会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] TOF-PET/CT装置の検出器リング数の違いに関する検討(2) -PSF補正・TOF補正効果の違い-2012

    • Author(s)
      谷口隆文、他7名.
    • Organizer
      第32回 日本核医学技術学会総会学術大会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] TOF-PET/CT装置の検出器リング数の違いに関する検討(3) -収集時間と放射能濃度の影響-2012

    • Author(s)
      赤松 剛、他7名.
    • Organizer
      第32回 日本核医学技術学会総会学術大会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 振幅同期を用いた呼吸同期PETの有用性の検討2012

    • Author(s)
      木寺大輔、他9名.
    • Organizer
      第7回 九州放射線医療技術学術大会
    • Place of Presentation
      長崎大学ポンぺ会館(長崎市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] PSF補正PET/CT画像におけるedge artifactの評価2012

    • Author(s)
      木原 謙、他9名.
    • Organizer
      第7回 九州放射線医療技術学術大会
    • Place of Presentation
      長崎大学ポンぺ会館(長崎市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 異なるPET装置を用いた乳癌FDG二相検査への部分容積効果補正の効果2012

    • Author(s)
      三笠翔平、他8名.
    • Organizer
      第7回 九州放射線医療技術学術大会
    • Place of Presentation
      長崎大学ポンぺ会館(長崎市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Impact of PSF and TOF on improving clinical PET/CT images in relation to BMI and injected dose.2011

    • Author(s)
      Akamatsu G, Ishikawa K, Zhang T, Takagi S, Ohya N, Mitsumoto K, Enomoto M, Yamaguchi K, Sasaki M.
    • Organizer
      EANM'11 - Annual Congress of the European Association of Nuclear Medicine.
    • Place of Presentation
      Birmingham/UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Determination of the Optimal Acquisition Protocol of Breath-Hold PET/CT for the Diagnosis of Thoracic Lesions.2011

    • Author(s)
      Mitsumoto K, Abe K, Sakaguchi Y, Zhang T, Tachiya Y, Ohya N, Sasaki M.
    • Organizer
      EANM'11 - Annual Congress of the European Association of Nuclear Medicine.
    • Place of Presentation
      Birmingham/UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Computerized Estimation of Possible Clinical Target Volume Based on Multimodality Images Using A Dual Active Contour Model.2011

    • Author(s)
      Kuwazuru J, Arimura H, Shioyama Y, Taniyama E, Sasaki M, Magome T, Nakamura K, Honda H, Toyofuku F, Hirata H.
    • Organizer
      ASRTO (American Society for Radiation Oncology) 53rd annual meeting.
    • Place of Presentation
      Miami Beach, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Impact of PSF and TOF on improving PET/CT images using a large phantom.2011

    • Author(s)
      Akamatsu G, Mitsumoto K, Taniguchi T,Kasahara Y, Ohya N, Umezu Y, Komiya I, Tsutsui Y, Sasaki M
    • Organizer
      6th Japan-Korea Joint Meeting on Medical Physics. 11th Asia-Oceania Congress of Medical Physics (JKMP-AOCMP Congress 2011).
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] PSF および TOF 補正 PET 画像における至適再構成条件の検討.2011

    • Author(s)
      張鉄嬌,光元勝彦, 石川香,赤松剛,大屋信義,高木真三,佐々木雅之.
    • Organizer
      第30回日本核医学技術学会総会学術大会.
    • Place of Presentation
      さいたま市
    • Related Report
      2012 Final Research Report
  • [Presentation] PET/CT検査におけるPSF補正およびTOF補正の効果と体格・FDG投与量との関係2011

    • Author(s)
      赤松剛, 他6名
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      (web開催)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impact of PSF and TOF on improving PET/CT images using a large phantom2011

    • Author(s)
      Akamatsu G, 他8名
    • Organizer
      6th Japan-Korea Joint Meeting on Medical Physics 11th Asia-Oceania Congress of Medical Physics (JKMP-AOCMP Congress 2011)
    • Place of Presentation
      Kyushu University (Fukuoka)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Improvement of PET/CT image quality using a large phantom by PSF and TOF in relation to the acquisition time and reconstruction parameters2011

    • Author(s)
      Mitsumoto K, 他8名
    • Organizer
      6th Japan-Korea Joint Meeting on Medical Physics 11th Asia-Oceania Congress of Medical Physics (JKMP-AOCMP Congress 2011)
    • Place of Presentation
      Kyushu University (Fukuoka)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Computerized Estimation of Possible Clinical Target Volume Based on Multimodality Images Using A Dual Active Contour Model2011

    • Author(s)
      Kuwazuru J, 他8名
    • Organizer
      ASRTO (American Society for Radiation Oncology) 53rd annual meeting
    • Place of Presentation
      Miami Beach, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impact of PSF and TOF on improving clinical PET/CT images in relation to BMI and injected dose2011

    • Author(s)
      Akamatsu G, 他8名
    • Organizer
      EANM'11-Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Birmingham/UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impact of PSF and TOF in PET/CT : Performance evaluation and initial experience2011

    • Author(s)
      Akamatsu G, 他5名
    • Organizer
      EANM'11-Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Birmingham/UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大口径ファントムを用いたPSF補正・TOF補正の効果の検討(1):収集時間および再構成条件の影響2011

    • Author(s)
      光元勝彦, 他8名
    • Organizer
      第31回日本核医学技術学会総会学術大会
    • Place of Presentation
      つくば市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大口径ファントムを用いたPSF補正・TOF補正の効果の検討(2):放射能濃度の影響2011

    • Author(s)
      赤松剛, 他8名
    • Organizer
      第31回日本核医学技術学会総会学術大会
    • Place of Presentation
      つくば市
    • Related Report
      2011 Annual Research Report
  • [Presentation] TOF-PET/CTによる大口径ファントムのContrast/Noise比の改善2011

    • Author(s)
      笠原有紀子, 他8名
    • Organizer
      第6回九州放射線医療技術学術大会、第60回(社)日本放射線技術学会九州部会学術大会、第57回九州放射線技師学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 異なるコントラスト比におけるリカバリ係数のTOF補正による改善2011

    • Author(s)
      谷口隆文, 他6名
    • Organizer
      第6回九州放射線医療技術学術大会、第60回(社)日本放射線技術学会九州部会学術大会、第57回九州放射線技師学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2011 Annual Research Report
  • [Presentation] FDGのリンパ節集積に対するTOF補正の影響2011

    • Author(s)
      赤松剛, 他6名
    • Organizer
      第6回九州放射線医療技術学術大会、第60回(社)日本放射線技術学会九州部会学術大会、第57回九州放射線技師学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2011 Annual Research Report
  • [Presentation] PET/CT検査におけるPSF補正およびTOF補正の効果と体格との関係の検討2010

    • Author(s)
      赤松剛, 他8名
    • Organizer
      第5回 九州放射線医療技術学術大会
    • Place of Presentation
      熊本市熊本市民会館
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] PET/CT検査の画質に与える投与量の影響とPSF補正およびTOF補正による改善2010

    • Author(s)
      石川香, 他8名
    • Organizer
      第5回 九州放射線医療技術学術大会
    • Place of Presentation
      熊本市熊本市民会館
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] PSFおよびTOF補正PET画像における至適再構成条件の検討2010

    • Author(s)
      張鉄嬌, 他6名
    • Organizer
      第30回日本核医学技術学会総会学術大会
    • Place of Presentation
      さいたま市大宮ソニックシティ
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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