R&D of multiple-molecular simultaneous imaging technology for clinical use

• Project/Area Number: 22611017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: MOTOMURA Shinji 独立行政法人理化学研究所, 複数分子イメージング研究チーム, 研究員 (20360654)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: コンプトンカメラ / 半導体検出器 / 放射線計測 / 核医学 / ガンマ線イメージング / 複数分子同時イメージング / 放射線

Research Abstract

We have evaluated the imaging performance of the semiconductor Compton camera GREI to establish the multiple-molecular simultaneous imaging as an innovative molecular imaging technology in nuclear medicine. We have designed a GREI system for human and found three-dimensional imaging with 2 mm spatial resolution is possible. The improvement of the three-dimensional tomographic imaging performance was demonstrated by an RI phantom imaging experiment with opposed-type GREI system. We have also made a quantitative consideration on the radiation exposure by higher-energy gamma rays.

Research Products

• [Journal Article] Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms (2013)
  • Author(s): Shinji Motomura, Yousuke Kanayama, Makoto,Hiromura, Tomonori Fukuchi, Takahiro Ida, Hiromitsu Haba, Yasuyoshi Watanabe, and Shuichi Enomoto
  • Journal Title: J. Anal. Atom. Spectrom Volume: 28 Issue: 6 Pages: 934-939
  • DOI: 10.1039/c3ja30185k
  • Peer Reviewed
• [Journal Article] 複数分子同時イメージング装置の開発とその応用研究 (2010)
  • Author(s): 榎本秀一, 本村信治
  • Journal Title: 中国科学技術月報 Volume: 49
  • URL: http://www.spc.jst.go.jp/hottopics/1011medical_diagnosis/r1011_enomoto.html
• [Journal Article] 複数分子同時イメージング装置の開発とその応用研究 (2010)
  • Author(s): 榎本秀一、本村信治
  • Journal Title: 中国科学技術月報 Volume: 49
• [Journal Article] 半導体コンプトンカメラによる複数分子同時イメージング法の開発
  • Author(s): 本村信治、榎本秀一
  • Journal Title: 電気学会技術報告 Volume: (印刷中)
  • NAID: 10025623543
• [Presentation] Improvement of Three-Dimensional Tomographic Imaging Performance by Opposed-Type Semiconductor Compton Camera System (2012)
  • Author(s): S. Motomura, T. Fukuchi, T. Ida, M. Hiromura, H. Haba, Y. Watanabe, and S. Enomoto
  • Organizer: 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Anaheim, CA, USA
  • Year and Date: 2012-11-02
• [Presentation] 対向型半導体コンプトンカメラによる小動物用複数分子同時イメージング技術の開発 (2012)
  • Author(s): 本村信治、福地知則、廣村 信、羽場宏光、渡辺恭良、榎本秀一
  • Organizer: 第7回日本分子イメージング学会
  • Place of Presentation: 浜松
  • Year and Date: 2012-05-24
• [Presentation] Improvement of Three-Dimensional Tomographic Imaging Performance by Opposed-Type Semiconductor Compton Camera (2012)
  • Author(s): Shinji Motomura, Tomonori Fukuchi, Takahiro Ida, Makoto Hiromura, Hiromitsu Haba, Yasuyoshi Watanabe, and Shuichi Enomoto
  • Organizer: 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Anaheim, CA, USA
• [Presentation] 新規核医学診断法創出に向けたGe半導体コンプトンカメラにおける逐次近似画像再構成法の検討 (2011)
  • Author(s): 猪田敬弘、本村信治, 他2名
  • Organizer: 第9回次世代を担う若手のためのフィジカル・ファーマフォーラム
  • Place of Presentation: 箱根
  • Year and Date: 2011-09-12
• [Presentation] Development of semiconductor Compton camera GREI toward simultaneous analysis of metals and metal-associated molecules in living organisms (2011)
  • Author(s): Shinji Motomura, Tomonori Fukuchi, Makoto Hiromura, Hiromitsu Haba, Yasuyoshi Watanabe, and Shuichi Enomoto
  • Organizer: 5^<th> International Conference on Metals and Genetics
  • Place of Presentation: Kobe
  • Year and Date: 2011-09-05
• [Presentation] Development of semiconductor Compton camera GREI toward simultaneous analysis of metals and metal-associated molecules in living organisms (2011)
  • Author(s): 本村信治, 他5名
  • Organizer: 5th International Conference on Metals and Genetics
  • Place of Presentation: 神戸
  • Year and Date: 2011-09-05
• [Presentation] アレイ型半導体コンプトンカメラの開発とヒト用複数分子同時イメージング技術の検討 (2011)
  • Author(s): 本村 信治, 福地 知則, 羽場 宏光, 渡辺 恭良, 榎本 秀一
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-27
• [Presentation] アレイ型半導体コンプトンカメラの開発とヒト用複数分子同時イメージング技術の検討 (2011)
  • Author(s): 本村信治, 他4名
  • Organizer: 第5回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-27
• [Presentation] Improved Imaging Performance of Semiconductor Compton Camera GREI for Multiple Molecular Simultaneous Imaging (2010)
  • Author(s): Motomura Shinji, Fukuchi Tomonori, Takeda Shinichiro, Kanayama Yousuke, Haba Hiromitsu, Watanabe Yasuyoshi, Enomoto Shuichi
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-08
• [Presentation] Improved Imaging Performance of Semiconductor Compton Camera GREI for Multiple Molecular Simultaneous Imaging (2010)
  • Author(s): 本村信治, 他6名
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: 京都
  • Year and Date: 2010-09-08
• [Presentation] 複数分子同時イメージング実現に向けたSi(Li)検出器装着型GREIの開発と低エネルギーガンマ線のコンプトンイメージング (2010)
  • Author(s): 本村信治, 他6名
  • Organizer: 第5回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 滋賀県大津市
  • Year and Date: 2010-05-14