Pathophysiology of transneuronal degeneration in patients with cerebral infarcts investigated with molecular imaging methods
| Project/Area Number |
22613001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Non-invasive neuroimaging
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| Research Institution | 滋賀県立成人病センター研究所 (2012)
Research Institute, Shiga Medical Center (2011)
Kyoto University (2010) |
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Principal Investigator |
YAMAUCHI Hiroshi 滋賀県立成人病センター研究所, 画像研究部門, 副所長 (40360812)
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| Research Collaborator |
HIGASHI Tatsuya 滋賀県立成人病センター研究所, 画像研究部門, 総括研究員
KAGAWA Shinya 滋賀県立成人病センター研究所, 画像研究部門, 研究員
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳梗塞 / 分子イメージング / ポジトロンCT / 中枢性ベンゾジアゼピン受容体 / 脳・神経 / 脳卒中 / ポジトロンＣＴ / 脳主幹動脈閉塞症 / ベンゾジアゼピン受容体 / 選択的神経細胞障害 |
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| Research Abstract |
We measured the central benzodiazepine receptors (cBZRs) using positron emission tomography in patients with major cerebral artery disease and cerebral infarction. Neuronal damage manifested as a decrease in the cBZRs was found not only in the non-infarcted cerebral cortex, possibly through primary ischemia, but also in the thalamus, possibly through transneuronal degeneration. A decrease in the cBZRs in the cerebral cortex showed a statistically significant correlation with cognitive dysfunction but that in the thalamus did not.
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Report
(4 results)
Research Products
(36 results)
