Analysis of early stage dementia patients using amyloid PET technique and neuropsychological examination.

• Project/Area Number: 22613002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Non-invasive neuroimaging
• Research Institution: Kyoto University
• Principal Investigator: TAKECHI Hajime 京都大学, 大学院・医学研究科, 講師 (10314197)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Hiroyuki 大阪市立大学, 医学研究科, 准教授 (90254391) ; ATAKA Suzuka 大阪市立大学, 医学研究科, 研究医 (40549755) ; HAMAKAWA Yoshiyuki 京都大学, 医学研究科, 助教 (50422960)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アルツハイマー型認知症 / アミロイドイメージング / 認知症 / アルツハイマー / アミロイド / PIB-PET / 神経心理学的検査

Research Abstract

Recent development of amyloid imaging made it possible to diagnose Alzheimer’ s disease referring pathological information. This new diagnostic chance revealed that there are some cases who are clinically diagnosed as AD but show amyloid imaging negative results. In this study, we showed there are neuropsychologically distinct groups of patients in the amyloid imaging negative cases. Patients of frontotemporal degeneration and idiopathic normal pressure hydrocephalus may be two of such groups.

Research Products

• [Journal Article] Global brain atrophy is associated with physical performance and the risk of falls in older adults with cognitive impairment (2013)
  • Author(s): Yamada M, Takechi H, Mori S, Aoyama T, Arai H
  • Journal Title: Geriatr Gerontol Int Volume: 13(2) Issue: 2 Pages: 437-42
  • DOI: 10.1111/j.1447-0594.2012.00927.x
  • Peer Reviewed
• [Journal Article] Relative Preservation of Advanced Activities in Daily Living among Patients with Mild-to-Moderate Dementia in the Community and Overview of Support Provided by Family Caregivers (2012)
  • Author(s): Takechi H, Kokuryu A, Kubota T, Yamada H
  • Journal Title: International Journal of Alzheimer's Disease Volume: vol. 2012, Article ID 418289 Pages: 7-7
  • DOI: 10.1155/2012/418289
  • NAID: 120004754364
  • Peer Reviewed
• [Journal Article] Intraneuronally Injected Amyloid Beta Inhibits Long-Term Potentiation In Rat Hippocampal Slices (2012)
  • Author(s): Nomura I, Takechi H, Kato N
  • Journal Title: J Neurophysiol Volume: 107(9) Issue: 9 Pages: 2526-31
  • DOI: 10.1152/jn.00589.2011
• [Journal Article] Both conventional indices of cognitive function and frailty predict levels of care required in a long-term care insurance program for memory clinic patients in (2012)
  • Author(s): Takechi H, Sugihara Y, Kokuryu A, Nishida M, Yamada H, Arai H, and Hamakawa Y
  • Journal Title: Japan Geriat Gerontol Int Volume: 12(4) Issue: 4 Pages: 630-6
  • DOI: 10.1111/j.1447-0594.2011.00828.x
  • Peer Reviewed
• [Journal Article] Clinical Course of Patients with Familial Early-Onset Alzheimer's Disease Potentially Lacking SenilePlaques Bearing the E693delta Mutation in Amyloid Precursor Protein (2011)
  • Author(s): Shimada H, Ataka S, Tomiyama T, Takeuchi H, Mori H, Miki T
  • Journal Title: Dement Geriatr Cogn Disord Volume: 32 Issue: 1 Pages: 45-54
  • DOI: 10.1159/000330017
  • Peer Reviewed
• [Journal Article] Clinical Course of Patients with Familial Early-Onset Alzheimer's Disease Potentially Lacking Senile Plaques Bearing the E693 Mutation in (2011)
  • Author(s): Shimada H, et al
  • Journal Title: Dement Geriatr Cogn Disord Volume: 32 Pages: 45-54
  • Peer Reviewed
• [Journal Article] Psychosocial quality of life of elderly hemodialysis patients using visual analog scale : Comparison with healthy elderly in Japan (2011)
  • Author(s): Kanamori H, et al
  • Journal Title: J Clinical Gerontol Geriat Volume: 2 Pages: 116-120
  • Peer Reviewed
• [Journal Article] Scenery Picture Memory Test, a New Type of Quick and Effective Screening Test to Detect Early Stage Alzheimer Disease Patients. (2010)
  • Author(s): Takechi H, Dodge H.
  • Journal Title: Geriatrics Gerontology International Volume: 10 Pages: 183-190
  • Peer Reviewed
• [Journal Article] 若年認知症の患者が診断を受けるまでの家族の行動プロセス 早期診断につなげるために必要な支援の考察 (2010)
  • Author(s): 田中晴佳, 武地一, 杉山博通, 藤本理恵子, 木下彩栄, 櫻庭繁
  • Journal Title: 日本認知症ケア学会誌 Volume: 9 Pages: 507-518
  • NAID: 40018717601
  • Peer Reviewed
• [Journal Article] 認知症高齢者の家族が行う意思決定過程と影響要因に関する研究家族介護者の語りの介護開始時期からの分析 (2010)
  • Author(s): 杉原百合子, 山田裕子, 武地一
  • Journal Title: 日本認知症ケア学会誌 Volume: 9 Pages: 44-55
  • NAID: 40018717577
  • Peer Reviewed
• [Presentation] 非 AD 疾患の鑑別診断におけるアミロイドPET の有用性 (2012)
  • Author(s): 武地 一, 濱川 慶之, 久保田智子, 福山 秀直
  • Organizer: 第54回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 非AD疾患の鑑別診断におけるアミロイドPETの有用性 (2012)
  • Author(s): 武地一
  • Organizer: 第54回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] アルツハイマー型認知症との鑑別診断におけるPIB-PETの役割 (2011)
  • Author(s): 武地一, 他5名
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] アルツハイマー病と診断されたがPiB-PETは陰性であった12症例の追跡結果 (2011)
  • Author(s): 安宅鈴香, 他8名
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-16
• [Presentation] 軽度の認知機能低下者における脳萎縮と転倒との関連 (2011)
  • Author(s): 山田実, 武地一, 青山朋樹, 荒井秀典
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京
• [Presentation] 新しい時計描画テスト採点基準の試み國立淳子 (2011)
  • Author(s): 武地一
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京
• [Presentation] アルツハイマー型認知症との鑑別診断における PIB-PET の役割 (2011)
  • Author(s): 武地一, 大石直也, 安宅鈴香, 濱川慶之, 嶋田裕之, 福山秀直
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京
• [Presentation] アルツハイマー病と診断されたがPiB-PET は陰性であった 12 症例の追跡結果 (2011)
  • Author(s): 安宅鈴香, 嶋田裕之, 竹内潤, 中弘志, 正木秀樹, 中西亜紀, 和田康弘, 武地一, 三木隆己
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 時計描画テスト採点における不一致について (2011)
  • Author(s): 國立淳子, 國崎貴弘, 高橋紗也子, 武地一
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 公共交通機関の利用の可否には認知機能と運動機能が関与している (2011)
  • Author(s): 山田実, 武地一, 荒井秀典, 青山朋樹, 市橋則明
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京
• [Presentation] もの忘れ外来通院患者の初診時からの抑うつ度GDSの経過 (2010)
  • Author(s): 武地一, 森田麻衣子, 國立淳子, 濱川慶之
  • Organizer: 日本老年医学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-26
• [Presentation] Characteristics of neuropsychological findings of clinically diagnosed Alzheimer disease and mild cognitive impairment patients but negative for amyloid imaging. (2010)
  • Author(s): Hajime Takechi, Suzuka Ataka, Maiko Nishida, Takami Miki, Hiroyuki Shimada.
  • Organizer: 13^<th> International Conference on Alzheimer's Disease
  • Place of Presentation: Honolulu, Hawaii