A new MRI method for axonal activity visualization

• Project/Area Number: 22613004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Non-invasive neuroimaging
• Research Institution: National Institute of Information and Communications Technology
• Principal Investigator: LIU Guoxiang 独立行政法人情報通信研究機構, 未来ICT研究所脳情報通信研究室, 主任研究員 (40358817)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Yoshichika 大阪大学, 学内共同利用施設等, 教授 (00174897)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 白質での神経活動 / MR計測 / fMRI / BOLD / white matter / EPI / f MRI

Research Abstract

A new MRI pulse sequence was developed for axonal activity visualization. The activities at white matter of human brain, especially at corpus callosum were investigated using the proposed method. And we found the responds during tapping and visual stimuli. In rat studies, the activities at axons connected to amygdala were detected using MRI.

Research Products

• [Journal Article] Critical role of Trib1 for the differentiation of adipose tissue-resident macrophages maintaining metabolic homeostasis. (2013)
  • Author(s): Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S
  • Journal Title: Nature Volume: 495(7442) Issue: 7442 Pages: 524-528
  • DOI: 10.1038/nature11930
  • Peer Reviewed
• [Journal Article] Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors (2012)
  • Author(s): Ma Q, Nakane Y, Mori Y, Hasegawa M, Yoshioka Y, Watanabe TM, Gonda K, Ohuchi N, Jin T
  • Journal Title: Biomaterials Volume: Vol 33 Pages: 8486-8494
  • Peer Reviewed
• [Journal Article] ^<19>F MRI monitoring of Gene Expression in Living Cells via Cell Surface β-Lactamase Activity (2012)
  • Author(s): 松下尚嗣、水上進、杉原文徳、白川昌宏、菊地和也
  • Journal Title: ChemBioChem Volume: 13 Issue: 11 Pages: 1579-1583
  • DOI: 10.1002/cbic.201200331
  • Peer Reviewed
• [Journal Article] Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors (2012)
  • Author(s): Ma Q
  • Journal Title: Biomaterials Volume: 33 Pages: 8486-8494
  • Peer Reviewed
• [Journal Article] 19F MRI Monitoring of Gene Expression in Living Cells through Cell-Surface b-Lactamase Activity (2012)
  • Author(s): Matsushita H
  • Journal Title: Chem Bio Chem Volume: 13 Pages: 1579-1583
  • Peer Reviewed
• [Journal Article] In vivo diagnostic imaging using micro-CT : sequential and comparative evaluation of rodent models for hepatic/brain ischemic and stroke (2012)
  • Author(s): Hayasaka N
  • Journal Title: PLoS One Volume: 7(2) Issue: 2 Pages: e32342-e32342
  • DOI: 10.1371/journal.pone.0032342
  • Peer Reviewed
• [Journal Article] Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice (2011)
  • Author(s): Wang T. Takikawa Y. Satoh T. Yoshioka Y. Kosaka K. Tatemichi Y. Suzuki K
  • Journal Title: Hepatology Research Volume: Vol 41 No.1 Pages: 87-92
  • Peer Reviewed
• [Journal Article] MR Contrast in Mouse Lymph Nodes with Subcutaneous Administration of Iron Oxide Particles: Size Dependency (2011)
  • Author(s): Mori Y. Umeda M. Fukunaga M. Ogasawara K. Yoshioka Y
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 10 Issue: 4 Pages: 219-227
  • DOI: 10.2463/mrms.10.219
  • NAID: 10030284563
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice (2011)
  • Author(s): Wang T
  • Journal Title: Hepatology Research Volume: 41 Issue: 1 Pages: 87-92
  • DOI: 10.1111/j.1872-034x.2010.00747.x
  • Peer Reviewed
• [Journal Article] MR contrast in mouse lymph nodes with subcutaneous administration of iron oxide particles : size dependency (2011)
  • Author(s): Mori Y
  • Journal Title: Magn Reson Med Sci Volume: 10 Pages: 219-227
  • Peer Reviewed
• [Journal Article] In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemic and stroke (2010)
  • Author(s): Hayasaka N. Nagai N. Kawao N. Niwa A. Yoshioka Y. Mori Y. Shigeta H. Kashiwagi N. Miyazawa M. Stou T. Higashino H. Matsuo 0. Murakami T
  • Journal Title: PLoS One Volume: Vol 7, No.2
  • Peer Reviewed
• [Journal Article] Correction of Shearing Distortions in Echo-Planar Imaging (2010)
  • Author(s): Liu G. Oshio K. Ogawa S. Murata T.
  • Journal Title: IEEE Trans. on Magnetics Volume: Vol. 46, No. 7 Pages: 2628-2634
  • Peer Reviewed
• [Journal Article] The brain mapping of the retrieval of conditioned taste aversion memory using manganese-enhancedmagnetic resonance imaging in rats (2010)
  • Author(s): Inui-Yamanomoto C. Yoshioka Y. Inui T. Sasaki K. S. Ooi Y. Ueda K. Seiyama A. Ohzawa I.
  • Journal Title: Neuroscience Volume: Vol. 167, No. 2 Pages: 199-204
  • Peer Reviewed
• [Journal Article] Brain Temperature Measured by Proton Magnetic Resonance Spectroscopy Predicts Cerebral Hyperperfusion after Carotid Endarterectomy (2010)
  • Author(s): Murakami T. Ogasawara K. Yoshioka Y. Ishigaki D. Sasaki M. Kudo K. Aso K. Nishimoto H
  • Journal Title: Radiology Volume: Vol. 46, No. 7 Pages: 924-931
  • Peer Reviewed
• [Journal Article] Correction for shearing distortions in EPI (2010)
  • Author(s): 劉国相
  • Journal Title: IEEE Trans.on Magnetics Volume: 24(7) Pages: 2628-2634
  • Peer Reviewed
• [Journal Article] The brain mapping of the retrieval of conditioned taste aversion memory using manganese-enhanced magnetic resonance imaging in rats (2010)
  • Author(s): Inui-Yamamoto C
  • Journal Title: Neuroscience Volume: 167(2) Pages: 199-204
  • Peer Reviewed
• [Journal Article] Brain Temperature Measured by Proton Magnetic Resonance Spectroscopy Predicts Cerebral Hyperperfusion after Carotid Endarterectomy (2010)
  • Author(s): Murakami T
  • Journal Title: Radiology Volume: 256 Pages: 924-931
  • Peer Reviewed
• [Presentation] White matter fMRI using intra-voxel phase gradient (2012)
  • Author(s): Liu G
  • Organizer: 18th Annual meeting of Human Brain Mapping
  • Place of Presentation: China National Convention Center, Bei Jing, China
  • Year and Date: 2012-06-14
• [Presentation] High-Resolution MR Lymphangiography in Mice Using Double Contrast Agents at 11.7 T (2012)
  • Author(s): Mori Y
  • Organizer: The 20th Annual Meeting of International Society of Magnetic Resonance in Medicine
  • Place of Presentation: Convention & Exhibition Centre,Melbourne, Australia
• [Presentation] The Investigation of Apparent Diffusion Coefficient in Renal Cortex and Medulla During the Cardiac Cycle (2012)
  • Author(s): Umeda M
  • Organizer: 20th Annual Meeting of International Society of Magnetic Resonance in Medicine
  • Place of Presentation: Convention & Exhibition Centre,Melbourne, Australia
• [Presentation] White matter fMRI using intra-voxel phase gradient (2012)
  • Author(s): Liu G
  • Organizer: 18th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: China National Convention Center, Bei Jing, China
• [Presentation] White matter fMRI using dual-spin echo EPI (2011)
  • Author(s): Liu G
  • Organizer: 17th Annual meeting of Human Brain Mapping
  • Place of Presentation: Centre des Congres de Quebec, Quebec City, Canada
  • Year and Date: 2011-09-01
• [Presentation] 生理的条件下での脳内温度の変動が見えてきた (2011)
  • Author(s): 吉岡芳親
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都府京都市京都国際会館(招待)
• [Presentation] Possible origin of negative BOLD response (2010)
  • Author(s): Liu G.
  • Organizer: 16th Annual meeting of Human Brain Mapping, 2010/6/10 Catalonia Palace of Congresses
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-10
• [Presentation] Possible origin of negative BOLD response (2010)
  • Author(s): 劉国相
  • Organizer: 16th Annual meeting of Human Brain Mapping
  • Place of Presentation: Catalonia Palace of Congresses, Barcelona, Spain
  • Year and Date: 2010-06-10
• [Presentation] 磁気共鳴法を用いたヒト脳の非侵襲的温度測定 (2010)
  • Author(s): 吉岡芳親
  • Organizer: Thermal neuromodulation ブラッシュアップカンファレンス
  • Place of Presentation: 山口大学,山口(招待講演)
  • Year and Date: 2010-05-27
• [Book] からだと温度の辞典 (2010)
  • Author(s): 吉岡芳親
  • Total Pages: 650
  • Publisher: 朝倉書店
• [Patent(Industrial Property Rights)] 共振回路 (2012)
  • Inventor(s): 吉岡芳親・朱大松
  • Industrial Property Rights Holder: 吉岡芳親・朱大松
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-05-24
  • Overseas
• [Patent(Industrial Property Rights)] ダイヤモンド複合粒子 (2012)
  • Inventor(s): 森田将史・清野智史・立川貴士・真嶋哲朗・吉岡芳親
  • Industrial Property Rights Holder: 森田将史・清野智史・立川貴士・真嶋哲朗・吉岡芳親
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-08