Molecular dynamics study on actin filament structure for revealing actin filament mechanosensing
| Project/Area Number |
22616002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Mechanobiology
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| Research Institution | Kyoto University |
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Principal Investigator |
INOUE Yasuhiro 京都大学, 再生医科学研究所, 准教授 (80442929)
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| Co-Investigator(Kenkyū-buntansha) |
HOJO Masaki 京都大学, 工学研究科, 教授 (70252492)
ADACHI Taiji 京都大学, 再生医科学研究所, 教授 (40243323)
西川 雅章 京都大学, 工学研究科, 准教授 (60512085)
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| Co-Investigator(Renkei-kenkyūsha) |
ADACHI Taiji 京都大学, 再生医科学研究所, 教授 (40243323)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アクチンフィラメント / メカノバイオロジー / メカノセンサー / 分子動力学シミュレーション / 分子動力学 / シミュレーション / in silico / アクチン / 分子構造ダイナミクス / 熱ゆらぎ |
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| Research Abstract |
Actin filament is responsible not only for mechanical properties of the cell but also mechanosensing of forces in the cell. However, molecular mechanism of the actin mechanosensing remains elusive. In this study, we performed molecular dynamics simulations of the actin filament, and clarified that the actin filament can display its mechanical condition to its surroundings by changing twist angle and fluctuations while sustaining mechanical organization of the filament with little longitudinal deformation.
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Report
(4 results)
Research Products
(60 results)
