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Functional analysis of a mechanical stress responsible geneFbxo32 on bone volume regulation

Research Project

Project/Area Number 22616006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Mechanobiology
Research InstitutionNagasaki University

Principal Investigator

IZUMI Shinichi  長崎大学, 大学院・医歯薬学総合研究科, 助教 (40264246)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Carolina Andrea  長崎大学, 大学院・医歯薬学総合研究科, 助教 (50437828)
MORIISHI Takeshi  長崎大学, 大学院・医歯薬学総合研究科, 技術職員 (20380983)
Co-Investigator(Renkei-kenkyūsha) KOMORI Toshihisa  長崎大学, 大学院・医歯薬学総合研究科, 教授 (00252677)
ITO Masako  長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10193517)
FUKUYAMA Ryo  広島国際大学, 薬学部, 助教 (20389117)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsメカニカルストレス / 遺伝子 / 骨量 / 細胞 / 組織 / 発生・分化 / Fbxo / Runx2 / 細胞・組織 / ノックアウト
Research Abstract

We clarified a part of molecular mechanisms on bone volume regulation by analyzingFbxo32 knockout mice. By bone morphometric analysis after mouse tail suspensionexperiments, it appeared that Fbxo32 gene expression in osteoblasts was associated with the bone volume but not bone density in the bone formation. Further, wild type mice and Fbxo32 knockout mice were administered isoproterenol, similar morphometric value between the femurs was recognized, indicating that Fbxo32 was not involved in a sympathetic nerve-stimulated decrease of bone volume.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] es bone loss at unloading by promoting osteoclastogenesis2012

    • Author(s)
      Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, and Komori T
    • Journal Title

      Bone

      Volume: 50 Pages: 409-419

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting2012

    • Author(s)
      Wang Y,Shinichi,I et al.
    • Journal Title

      Bone

      Volume: 50 Pages: 409-419

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis2012

    • Author(s)
      Wang Y, et al
    • Journal Title

      Bone

      Volume: 50 Pages: 409-419

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early onset of Runx2 expression causes craniosynostosis, ectopic bone formation, and limb defects2011

    • Author(s)
      Maeno T, Moriishi T, Yoshida C, Komori H, Kanatani N, Izumi S, Takaoka K, and Komori T
    • Journal Title

      Bone

      Volume: 49 Pages: 673-682

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation.2010

    • Author(s)
      Mikasa M, et al.
    • Journal Title

      J Bone Miner.Metab.

      Volume: (Epub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells.2010

    • Author(s)
      Ishigaki Y, et al.
    • Journal Title

      J Electr Microsc Technol Med Biol.

      Volume: 24(1) Pages: 8-13

    • Related Report
      2010 Annual Research Report
  • [Presentation] mRNAの分子構造可視化と結合タンパク質の機能解析2011

    • Author(s)
      石垣靖人, 他
    • Organizer
      医学生物学電子顕微鏡技術学会第27回学術講演会
    • Place of Presentation
      四国大学交流プラザ(徳島市)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨芽細胞分化における抗アポトーシス分子Bcl-2の役割2010

    • Author(s)
      森石武史、和泉伸一、小守壽文
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨芽細胞分化における抗アポトーシス分子Bc1-2の役割2010

    • Author(s)
      森石武史, 他
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] イオン液体の免疫電顕試料への帯電防止効果の検討2010

    • Author(s)
      和泉伸一, 他
    • Organizer
      医学生物学電子顕微鏡技術学会第26回学術講演会
    • Place of Presentation
      別府ビーコンプラザ(別府市)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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