| Project/Area Number |
22616008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Mechanobiology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Maki 東京慈恵会医科大学, 医学部, 講師 (30271315)
KIMURA Masako 女子栄養大学, 栄養学部, 准教授 (30328314)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Tetsuo 東京慈恵会医科大学, 医学部, 助教 (30233224)
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| Research Collaborator |
NAKAHARA Naoya 東京慈恵会医科大学, 医学部, 助教 (10632193)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 横紋筋 / エックス線回折 / 収縮 / 筋節 / X線回折 / スキンドファイバー / 骨格筋 / 心筋 / ゲルゾリン / ミオシン / サルコメア / アクチン / Spring8 / ブタンジオンモノオキシム |
|---|
| Research Abstract |
Stretch of sarcomeres of striated muscle induces higher contractile activity in striated muscle. Well organized fine structure of sarcomere is responsible to this stretch activation phenomenon, but its detailed mechanism has not been elucidated. Developing two-dimensional x-ray diffraction techniques, we found that stretch induces protrusion of myosin heads out of the thick filament backbone toward the neighboring actin molecules on thin filament so as to facilitate formation of contractile cross-bridges between myosin heads and actin molecules.
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