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Challenges to elucidate the role of ocular dominance columns for visual perception and to progress the study of OD plasticity in mouse

Research Project

Project/Area Number 22650068
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

TOMITA Koichi  生理学研究所, 行動・代謝分子解析センター, 特任助教 (80314285)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,160,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords分子・細胞神経科学 / 神経可塑性 / 神経科学 / 感覚認知
Research Abstract

The aim of this project is elucidating the role of ocular dominance(OD) columns during the depth perception. The mouse, devoid of OD columns, is normally weak in discriminating the visual distance. We originally found that a short form of molecular chaperone, which has a neurite-promoting activity, showed specific expression to the ipsilateral OD columns of the developing visual cortex in higher mammals. To directly test the role of OD columns in the depth perception, I am now investigating whether overexpression of ispilateral OD column-specific chaperone can induce OD columns in mouse visual cortex and, moreover, whether this mouse can show increased ability to discriminate the visual distance.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (17 results) Remarks (3 results)

  • [Journal Article] Multiple patterns of spatiotemporal changes in layer-specific gene expression in the developing visual cortex of higher mammals2012

    • Author(s)
      Tomita K, Gotoh H, Tomita K, Yamauchi N, Sanbo M
    • Journal Title

      Neurosci. Res

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of left ventricular mechanical work and energetics of normal hearts in SERCA2a transgenic rats2012

    • Author(s)
      Zhang GX, Obata K, Takeshita D, Mitsuyama S, Nakashima T, Kikuta A, Hirabayashi M, Tomita K, Vetter R, Dillmann WH, Takaki M.
    • Journal Title

      J Physiol Sci.

      Volume: Vol.62, No.3 Pages: 221-231

    • NAID

      10030742386

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of Kiss1 gene expression mediating estrogen positive feedback action in the mouse brain2012

    • Author(s)
      Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda K, Tsukamura H
    • Journal Title

      Proc. Natl. Acad. Sci.

      Volume: Vol.109, No.20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation2012

    • Author(s)
      Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, Takebayashi H
    • Journal Title

      Development

      Volume: Vol.139, No.6 Pages: 1125-1132

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene induction in mature oligodendrocytes with a PLP-tTA mouse line2012

    • Author(s)
      Inamura N, Sugio S, Macklin WB, Tomita K, Tanaka KF, Ikenaka K
    • Journal Title

      Genesis

      Volume: Vol.50, No.5 Pages: 424-428

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of left ventricular mechanical work and energetics of normal hearts in SERCA2a transgenic rats.2012

    • Author(s)
      Zhang GX, Obata K, Takaki M, 他8名
    • Journal Title

      J Physiol Sci

      Volume: 62 Issue: 3 Pages: 221-231

    • DOI

      10.1007/s12576-012-0200-4

    • NAID

      10030742386

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of Kiss1 gene expression mediating estrogen positive feedback action in the mouse brain2012

    • Author(s)
      Tomikawa J, et al
    • Journal Title

      Proc.Natl.Acad.Sci.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation2012

    • Author(s)
      Usui N, et al
    • Journal Title

      Development

      Volume: 139 Issue: 6 Pages: 1125-32

    • DOI

      10.1242/dev.069997

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene induction in mature oligodendrocytes with a PLP-tTA mouse line2011

    • Author(s)
      Inamura N, et al
    • Journal Title

      Genesis

      Volume: (online published) Issue: 5 Pages: 424-428

    • DOI

      10.1002/dvg.20808

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] A Molecular Correlate Of Ocular Dominance Columns In The Developing Mammalian Visual Cortex2012

    • Author(s)
      Koichi Tomita, Max Sperling, Tobias Bonhoeffer, Mark Huebener
    • Organizer
      The 59^<th> NIBB Conference-Neocortical Organization-
    • Place of Presentation
      Okazaki Conference center(Aichi)
    • Year and Date
      2012-03-12
    • Related Report
      2011 Final Research Report
  • [Presentation] A Molecular Correlate Of Ocular Dominance Columns In The Developing Mammalian Visual Cortex2012

    • Author(s)
      Koichi Tomita, et al
    • Organizer
      The 59^<th> NIBB Conference-Neocortical Organization-
    • Place of Presentation
      Okazaki Conference center (Aichi, Japan)
    • Year and Date
      2012-03-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] A molecular correlate of ocular dominance(OD) columns in the developing mammalian visual cortex2012

    • Author(s)
      Koichi Tomita, Max Sperling, Tobias Bonhoeffer, Mark Huebener
    • Organizer
      42nd NIPS International Symposium/NIPS and BRI Niigata University Joint Symposium
    • Place of Presentation
      Okazaki Yamate(Aichi)
    • Year and Date
      2012-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] A molecular correlate of ocular dominance (OD) columns in the developing mammalian visual cortex2012

    • Author(s)
      Koichi Tomita, et al
    • Organizer
      42nd NIPS International Symposium/NIPS and BRI Niigata University Joint Symposium
    • Place of Presentation
      Okazaki Yamate (Aichi, Japan)
    • Year and Date
      2012-03-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Generation of transgenic mice expressing GFP in two kisspeptin neuronal populations2012

    • Author(s)
      Teppei Goto, et al
    • Organizer
      42nd NIPS International Symposium/NIPS and BRI Niigata University Joint Symposium
    • Place of Presentation
      Okazaki Yamate (Aichi, Japan)
    • Year and Date
      2012-03-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transgenic mice expressing GFP in two populations of kisspeptin in the hypothalamus2011

    • Author(s)
      Teppei Goto, et al
    • Organizer
      WCRB2011
    • Place of Presentation
      Cairns (Australia)
    • Year and Date
      2011-10-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Kiss1遺伝子下流領域が前腹側室周囲核のキスペプチン発現に必須である2011

    • Author(s)
      後藤哲平, 他
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      いわて県民情報交流センター・アイーナ(岩手県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 感覚神経発生における運動ニューロン由来NT-3の役割2011

    • Author(s)
      臼井紀好, 他
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性腺刺激ホルモン放出ホルモンパルス発生機構における弓状核キスペプチンニューロンの役割2011

    • Author(s)
      中村翔, 他
    • Organizer
      第26回日本下垂体研究会
    • Place of Presentation
      せとうち児島ホテル(岡山県)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] トランスジェニックマウスを用いたキスペプチンニューロンの機能解析2011

    • Author(s)
      安部仁美, 他
    • Organizer
      第26回日本下垂体研究会
    • Place of Presentation
      せとうち児島ホテル(岡山県)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] A molecular correlate of ocular dominance (OD) columns in the developing visual cortex of higher mammals2011

    • Author(s)
      Koichi Tomita
    • Organizer
      Neuroscience Seminar Series in the University of Bordeaux
    • Place of Presentation
      University of Bordeaux (France)(招待講演)
    • Year and Date
      2011-08-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 緑色蛍光タンパク(GFP)によるキスペプチンニューロン可視化マウスの作出2011

    • Author(s)
      後藤哲平
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] A molecular correlate of ocular dominance(OD) columns in the developing mammalian visual cortex : a discovery of a molecule specific for ipsilateral OD columns2010

    • Author(s)
      Koichi Tomita, Max Sperling, Makoto Sanbo, Naoko Yamauchi, Tobias Bonhoeffer, Mark Huebener
    • Organizer
      第32回日本分子生物学会年会/BMB2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] A molecular correlate of ocular dominance (OD) columns in the developing mammalian visual cortex : a discovery of a molecule specific for ipsilateral OD columns2010

    • Author(s)
      Koichi Tomita
    • Organizer
      第33回日本分子生物学会年会/BMB2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 第一次視覚野発生初期における哺乳類同側・反対側眼優位カラムの分子的差異:同側眼優位カラムに特異的な分子の発見2010

    • Author(s)
      冨田江一, Max Sperling, Tobias Bonhoeffer, Mark Huebener
    • Organizer
      第33回日本神経科学大会/Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 発生期の同側眼優位カラムに特異的な因子の発見と今後の展望2010

    • Author(s)
      冨田江一, Max Sperling, Sidney B. Cambridge, Tobias Bonhoeffer, Mark Huebener
    • Organizer
      生理学研究所・名古屋大学医学部合同シンポジウム
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Year and Date
      2010-08-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ラット胚性幹細胞への外来遺伝子導入がキメラ個体の作製効率に及ぼす影響2010

    • Author(s)
      三宝誠
    • Organizer
      生理学研究所・名古屋大学医学部合同シンポジウム
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/mamtg/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/mamtg/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/mamtg/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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