Mechanisms of synapse formation in interneurons
| Project/Area Number |
22650070
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKABE Shigeo 東京大学, 大学院・医学系研究科, 教授 (60204012)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 分子神経生物学 / シナプス形成 / シナプス / PSD / 抑制性神経細胞 / 微小管 / 樹状突起 |
|---|
| Research Abstract |
We show that immature dendrites of interneurons form long protrusions and that these protrusions serve as conduits for retrograde translocation of synaptic contacts to the parental dendrites. This translocation process is dependent on microtubules and the activity of LIS1, an essential regulator of dynein-mediated motility. Suppression of this retrograde translocation results in disorganized synaptic patterns on interneuron dendrites. Taken together, these findings suggest the existence of an active microtubule-dependent mechanism for synaptic translocation that helps in the establishment of proper synaptic distribution on dendrites.
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Report
(3 results)
Research Products
(67 results)
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[Journal Article] RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex2012
Author(s)
Hirai, S.,Miwa, A., Ohtaka-Maruyama, C., Kasa,i M., Okabe, S., Hata, Y, and H. Okado
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Journal Title
EMBO Journal
Volume: 31
Issue: 5
Pages: 1190-1202
DOI
Related Report
Peer Reviewed
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[Journal Article] LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites2012
Author(s)
Kawabata, I., Kashiwagi, Y., Obashi, K., Ohkura, M., Nakai, J., Wynshaw-Boris, A., Yanagawa, Y., Okabe, S
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Journal Title
Nature Communications
Volume: 3
Issue: 1
Pages: 722-722
DOI
Related Report
Peer Reviewed
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[Presentation] Cbln1が制御する新しい小脳シナプス形成のメカニズム2011
Author(s)
石田綾,三浦会里子,宮崎太輔,松田恵子,渡辺雅彦,柚崎通介,岡部繁男
Organizer
第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
Place of Presentation
Journal of Physiological Sciences誌上開催
Year and Date
2011-03-30
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