| Project/Area Number |
22650075
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | 公益財団法人先端医療振興財団 (2012)
National Cardiovascular Center Research Institute (2010-2011) |
|---|
Principal Investigator |
TAGUCHI Akihiko 公益財団法人先端医療振興財団, 再生医療研究部, 部長 (10359276)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | 血管再生 / 造血系幹細胞 / 老化 / 若返り / 脳梗塞 / 腎障害 / 骨髄単核球 / Tie2 / 脳血管障害 |
|---|
| Research Abstract |
Circulating bone marrow-derived immature cells have been implicated in homeostasis of the microvasculature, and decreased levels of circulating endothelial progenitor cells, associated with aging, correlate with poor clinical outcomes in a range of cardiovascular diseases. We transplanted bone marrow cells from young stroke-prone spontaneously hypertensive rats (SHR-SP) into aged SHR-SP, and found that animals transplanted with bone marrow from young SHR-SP displayed an increase in density of the microvasculature in the periinfarction zone, reduced ischemic brain damage and improved neurologic function.
|
