| Project/Area Number |
22650078
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
NAKASHIMA Kinichi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (80302892)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 神経幹細胞 / 二分子蛍光補完 / 分化 / サイトカイン / アストロサイト |
|---|
| Research Abstract |
In this research, I have developed the method to detect the reception of cytokines(IL6-FCs, Interleukin-6 family of cytokines) signal by neural stem cells, which is essential for astrocyte differentiation of them using bi-molecular fluorescence complementation(BiFC). Furthermore, I identified that brain surface-covering meningeal cells express IL6-FC such as LIF, CNTF, CLC.
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