| Project/Area Number |
22650097
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHASHI Toshiro 北海道大学, 大学院・工学研究院, 教授 (30270812)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Eijiro 北海道大学, 大学院・工学研究院, 助教 (20581614)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | バイオチップ / 細胞接着制御 / 微小流路 / 細胞診断 / バイオ MEMS / バイオMEMS |
|---|
| Research Abstract |
This paper presents development of a technique to control cell adhesion usingan array of magnetic microbeads. Using MEMS techniques, we fabricated an array of microholes (3 μmin diameter and 2 μm in depth) on the surface of a glass substrate, to trap magnetic microbeads (2.8 μmin diameter) in the microholes. The magnetic microbeads were coated with fibronectin prior to theloading. A permanent magnet was placed under the substrate and was used to trap microbeads into themicroholes. After 24 hours incubation, it was observed that cells attached only to the magneticmicrobeads, but not to the other parts of the glass surface.
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