| Project/Area Number |
22650099
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAGA Yoichi 東北大学, 大学院・医工学研究科, 教授 (00282096)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,290,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 消化管 / 粘膜 / 人工臓器 / 潰瘍性大腸炎 / クローン病 / 再生医療 / intestinal mucosa / 上皮細胞 |
|---|
| Research Abstract |
We tried to construct"artificial intestinal mucosa", which is composed of villus-and crypt-like structures, using micro electric mechanical systems (MEMS), which are utilized for creating 3-demensional micro-constructs. We successfully made"small intestine"-like structures featured by multiple projections on the surface and"colon"-like structures with multiple hollows. We covered the irregular surface with the artificial membrane on the structures and cultured epithelial cells. We might generate an artificial mucosa by inventing a new system enabling exchange of molecules between epithelial cells and cells under basal membrane.
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