Molecular cell biomechanical analysis of novel pharmacological activity of monosaccharide
| Project/Area Number |
22650101
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Chiba University |
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Principal Investigator |
MATSUMOTO Akio 千葉大学, 大学院・医学研究院, 准教授 (60437308)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Takeo 名古屋工業大学, 大学院・工学研究科, 教授 (30209639)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAYAMA Kazuaki 名古屋工業大学, 大学院・工学研究科, 准教授 (10359763)
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| Research Collaborator |
OWAKI Yasushi 名古屋工業大学, 工学(系)研究科(研究院), 大学院生
FUJIWARA Akiko 千葉大学, 医学(系)研究科, 学生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,360,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | 生物・生体工学 / 形態変化 / 酸化ストレス / バイオメカニクス / 分子生物学 / 一酸化窒素 / 血管内皮細胞 / シグナル伝達 |
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| Research Abstract |
This research project gave a new insight into the action of monosaccharide as it causes mesh-formation on cultured mouse vascular endothelial cells, a part of angiogenic response in mono layered cells. The point of action is glycan on cell surface proteins ; a treatment of cells with monosaccharide causes modification of glycans on cell surface adhesive proteins, resulting in the alteration on adhesive forces of the cell. This project has an advantage on research team as they can share the favorite field for detailed analysis ; molecular biological analyses by the team of Chiba Univ. and functional analyses by using engineering techniques by the team of Nagoya Inst. Tech. Therefore, this project becomes a first step for conducting "Molecular Cell Biomechanics" research in combination with the scientists from different fields to fulfill higher demand in scientific project.
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Report
(3 results)
Research Products
(35 results)
