• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular cell biomechanical analysis of novel pharmacological activity of monosaccharide

Research Project

Project/Area Number 22650101
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionChiba University

Principal Investigator

MATSUMOTO Akio  千葉大学, 大学院・医学研究院, 准教授 (60437308)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Takeo  名古屋工業大学, 大学院・工学研究科, 教授 (30209639)
Co-Investigator(Renkei-kenkyūsha) NAGAYAMA Kazuaki  名古屋工業大学, 大学院・工学研究科, 准教授 (10359763)
Research Collaborator OWAKI Yasushi  名古屋工業大学, 工学(系)研究科(研究院), 大学院生
FUJIWARA Akiko  千葉大学, 医学(系)研究科, 学生
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,360,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords生物・生体工学 / 形態変化 / 酸化ストレス / バイオメカニクス / 分子生物学 / 一酸化窒素 / 血管内皮細胞 / シグナル伝達
Research Abstract

This research project gave a new insight into the action of monosaccharide as it causes mesh-formation on cultured mouse vascular endothelial cells, a part of angiogenic response in mono layered cells. The point of action is glycan on cell surface proteins ; a treatment of cells with monosaccharide causes modification of glycans on cell surface adhesive proteins, resulting in the alteration on adhesive forces of the cell. This project has an advantage on research team as they can share the favorite field for detailed analysis ; molecular biological analyses by the team of Chiba Univ. and functional analyses by using engineering techniques by the team of Nagoya Inst. Tech. Therefore, this project becomes a first step for conducting "Molecular Cell Biomechanics" research in combination with the scientists from different fields to fulfill higher demand in scientific project.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (27 results) Book (1 results)

  • [Journal Article] Development of an antibody-lectin enzyme immunoassay for fucosylated α-fetoprotein2012

    • Author(s)
      Korekane H
    • Journal Title

      Biochim Biophys Acta

      Volume: (印刷中) Issue: 9 Pages: 1405-1411

    • DOI

      10.1016/j.bbagen.2011.12.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SNO化制御の破綻と疾患2012

    • Author(s)
      松本明郎
    • Journal Title

      細胞工学

      Volume: 31 Pages: 171-172

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Membrane transfer of S-nitrosothiols2011

    • Author(s)
      Matsumoto A., Gow A
    • Journal Title

      Nitric Oxide

      Volume: 25 Issue: 2 Pages: 102-107

    • DOI

      10.1016/j.niox.2011.02.006

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Glycosylation profiling of recombinant mouse extracellular superoxide dismutase produced in Chinese hamster ovary cells2011

    • Author(s)
      Korekane H
    • Journal Title

      Glycoconj J

      Volume: 28 Issue: 3-4 Pages: 183-196

    • DOI

      10.1007/s10719-011-9333-6

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ATP-Sensitive K+ Channels and L-Type Ca2+ Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells2011

    • Author(s)
      Nishida A
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 116 Issue: 1 Pages: 73-80

    • DOI

      10.1254/jphs.10294FP

    • NAID

      10029894018

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ATP-sensitive K^+ channels and L-type Ca2+ channels by amiodarone elicits contradictory effect on insulin secretion in MIN6 cells.

    • Author(s)
      Nishida A.
    • Journal Title

      J Pharmacol Sci

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane transfer of S-nitrosothiols.

    • Author(s)
      Matsumoto A.
    • Journal Title

      Nitric Oxide

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス血管平滑筋細胞におけるS-nitrosoglutathione (GSNO)によるThioredoxin Interacting Protein (TxnIP)の二相性発現制御2012

    • Author(s)
      遠藤愛実
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋特異的Mn-SOD欠損マウスにおける心室不整脈易誘発性とリンゴポリフェノール投与による改善2012

    • Author(s)
      松本明郎
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] O由来ストレスによる血管内皮細胞の力学応答の解明に関する基礎研究2012

    • Author(s)
      高橋結宗, 松本明郎, 長山和亮, 松本健郎
    • Organizer
      日本機械学会東海学生会第43回学生員卒業研究発表講演会
    • Place of Presentation
      名古屋工業大学
    • Year and Date
      2012-03-14
    • Related Report
      2011 Final Research Report
  • [Presentation] NO由来ストレスによる血管内皮細胞の力学応答の解明に関する基礎研究2012

    • Author(s)
      高橋結宗
    • Organizer
      日本機械学会東海学生会第43回学生員卒業研究発表講演会
    • Place of Presentation
      名古屋工業大学
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性酸素によるシグナル伝達制御2011

    • Author(s)
      松本明郎
    • Organizer
      第84回日本生化学会大会(フォーラムオーガナイザ)
    • Place of Presentation
      京都国際会館
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性酸素によるシグナル伝達制御2011

    • Author(s)
      松本明郎
    • Organizer
      九州大学生体防御医学研究所 共同利用研究集会「活性酸素によるシグナル伝達制御の新展開」
    • Place of Presentation
      九州大学
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮細胞の形態変化に対する内因性・外因性一酸化窒素の影響2011

    • Author(s)
      松本明郎
    • Organizer
      第580回生医研セミナー
    • Place of Presentation
      九州大学(招待講演)
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] S-Nitrosothioによる細胞間情報伝達系の解明2011

    • Author(s)
      松本明郎
    • Organizer
      第75回Basic Science Joint Meeting (BSJM)
    • Place of Presentation
      千葉大学
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] アミオダロンのATP感受性K+チャネルとL型Ca^<2+>チャネルに対する抑制作用は互いに相殺し合ってMIN6細胞からのインスリン分泌を増強しない2011

    • Author(s)
      西田淳
    • Organizer
      第124回日本薬理学会関東部会
    • Place of Presentation
      東京大学
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膜を越えたS-nirosothiol伝達制御系の検討2011

    • Author(s)
      松本明郎
    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      昭和薬科大学
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] S-nitrosoglutathione (GSNO)によるThioredoxin Interacting Protein (TxnIP)の二相性発現制御2011

    • Author(s)
      遠藤愛実
    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      昭和薬科大学
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Membrane Transfer of S-nitrosothiols, The 6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects -Development of Novel Therapy2011

    • Author(s)
      Matsumoto A
    • Organizer
      The 6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects -Development of Novel Therapy to Specific Disease in organ.
    • Place of Presentation
      京都大学
    • Year and Date
      2011-04-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Membrane Transfer of S-nitrosothiols2011

    • Author(s)
      Matsumoto A
    • Organizer
      The 6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects-Development of Novel Therapy to Specific Disease in organ-
    • Place of Presentation
      京都大学
    • Year and Date
      2011-04-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Membrane Transfer of S-nitrosothiols2011

    • Author(s)
      Matsumoto A.
    • Organizer
      Gordon Research Conference on Nitric Oxide
    • Place of Presentation
      ベンチュラ(米国)
    • Year and Date
      2011-02-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection and measurement of NO and its derivatives in biological samples.2011

    • Author(s)
      松本明郎
    • Organizer
      第567回生医研セミナー(多階層生体防御システム研究拠点)グローバルCOE理医連携セミナー
    • Place of Presentation
      九州大学(博多)(招待講演)
    • Year and Date
      2011-01-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮細胞の流れ負荷に伴う変形の量子ドットを用いた局所計測の試み2011

    • Author(s)
      大脇靖史, 長山和亮, 松本明郎, 松本健郎
    • Organizer
      第23回バイオエンジニアリング講演会
    • Place of Presentation
      熊本大学
    • Year and Date
      2011-01-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 血管内皮細胞の流れ負荷に伴う変形の量子ドソトを用いた局所計測の試み2011

    • Author(s)
      大脇靖史
    • Organizer
      第23回バイオエンジニアリング講演会
    • Place of Presentation
      熊本大学(熊本)
    • Year and Date
      2011-01-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮細胞の糖鎖除去による網目構造形成機構の解明に関する研究2011

    • Author(s)
      大脇靖史, 長山和亮, 松本明郎, 松本健郎
    • Organizer
      日本機械学会2011年度年次大会
    • Place of Presentation
      東京工業大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 一酸化窒素(No)による翻訳後修飾:S-nitrosylationとシグナル伝達の制御2010

    • Author(s)
      松本明郎
    • Organizer
      第564回生医研セミナー(多階層生体防御システム研究拠点)グローバルcoE理医連携セミナー
    • Place of Presentation
      九州大学(博多)(招待講演)
    • Year and Date
      2010-12-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transmembrane signal transduction by nitrosothiols2010

    • Author(s)
      松本明郎
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)シンポジウム
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] S-Nitrosothiolによる細胞間情報伝達系の制御2010

    • Author(s)
      松本明郎
    • Organizer
      第20回日本循環薬理学会
    • Place of Presentation
      札幌市教育文化会館(札幌)
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] S-nitrosoglutathione(GSNO)によるThioredoxin Interacting Protein(Txnip)の二相性発現制御2010

    • Author(s)
      遠藤愛実
    • Organizer
      第123回日本薬理学会関東部会
    • Place of Presentation
      自治医科大学(栃木県)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intracellular S-nitrosothiol (SNO) formation by extracellular NO sources2010

    • Author(s)
      Matsumoto A
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      京都国際会館
    • Year and Date
      2010-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Intracellular S-nitrosothiol(SNO)formation by entracellular NO sources2010

    • Author(s)
      Matsumoto A.
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional modifications of glycans on vascular endothelial cells by mono-saccharides2010

    • Author(s)
      Matsumoto A
    • Organizer
      nternational Society for Heart Research
    • Place of Presentation
      京都国際会館
    • Year and Date
      2010-05-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional modifications of glycans on vascular endothelial cells by mono-saccharides.2010

    • Author(s)
      Matsumoto A.
    • Organizer
      International Society for Heart Research 2010
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ghrelin Reduces Infarct Size via Activation of PI3-k and mitochondrial ATP sensitive K^+channels in Rabbit Hearts.2010

    • Author(s)
      Inamura N.
    • Organizer
      International Society for Heart Research 2010
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Book] 実践 臨床薬理学2010

    • Author(s)
      松本明郎(分担)
    • Total Pages
      312
    • Publisher
      朝倉書店
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi