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Innovative method of combined hepatic tissue regeneration by the connection of bile canaliculi and bile ducts

Research Project

Project/Area Number 22650106
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKeio University

Principal Investigator

SUDO Ryo  慶應義塾大学, 理工学部, 講師 (20407141)

Co-Investigator(Kenkyū-buntansha) TANISHITA Kazuo  慶應義塾大学, 理工学部, 教授 (10101776)
Co-Investigator(Renkei-kenkyūsha) IKEDA Mariko  慶應義塾大学, 理工学部, 名誉教授 (00051368)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,130,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords人工臓器工学 / 再生医工学 / 胆管上皮細胞
Research Abstract

The purpose of this study is to reconstruct a combined hepatic tissue by controlling oxygen concentration and elasticity in cellular microenvironments. Specifically, we aimed to combine bile canaliculi, which are formed by hepatocytes, and bile ducts, which are formed by biliary epithelial cells. Oxygen concentration was controlled using an oxygen permeable silicone membrane while elasticity was controlled by changing the elasticity of collagen gel that is a cellular scaffold. We found that oxygen concentration around cells is an important regulatory factor for combining bile ducts and bile canaliculi.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010

All Presentation (23 results)

  • [Presentation] 生体外における肝臓再生への工学的アプローチ2012

    • Author(s)
      須藤亮
    • Organizer
      分野横断型医工学研究プラットフォームBASIC特別講演会
    • Place of Presentation
      宮城
    • Year and Date
      2012-02-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体外における肝臓再生への工学的アプローチ2012

    • Author(s)
      須藤亮
    • Organizer
      分野横断型医工学研究プラットフォームBASIC特別講演会
    • Place of Presentation
      東北大学(宮城県)(招待講演)
    • Year and Date
      2012-02-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロ流体デバイスを用いた三次元組織再生への工学的アプローチ2012

    • Author(s)
      須藤亮
    • Organizer
      バイオフィジオロジー研究会
    • Place of Presentation
      京都
    • Year and Date
      2012-02-25
    • Related Report
      2011 Final Research Report
  • [Presentation] マイクロ流体デバイスを用いた三次元組織再生への工学的アプローチ2012

    • Author(s)
      須藤亮
    • Organizer
      バイオフィジオロジー研究会
    • Place of Presentation
      ホテル京都京阪(京都府)(招待講演)
    • Year and Date
      2012-02-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microfluidic culture models for investigating normal and cancer cell behaviors2012

    • Author(s)
      Ryo Sudo
    • Organizer
      バイオメカニクス懇話会
    • Place of Presentation
      北海道
    • Year and Date
      2012-01-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Microfluidic culture models for investigating normal and cancer cell behaviors2012

    • Author(s)
      Ryo Sudo
    • Organizer
      バイオメカニクス懇話会
    • Place of Presentation
      北海道大学(北海道)(招待講演)
    • Year and Date
      2012-01-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microfluidic hydrostatic deposition patterning for a confined hepatocyte-biliary epithelial cell co-culture system2011

    • Author(s)
      Yuyang Lee, Ryo Sudo, Tomoya Komatsu, Norihisa Miki, Toshihiro Mitaka, Mariko Ikeda, Kazuo Tanishita
    • Organizer
      2011 International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      愛知
    • Year and Date
      2011-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Microfluidic hydrostatic deposition patterning for a confined hepatocyte-biliary epithelial cell co-culture system2011

    • Author(s)
      Yuang Lee
    • Organizer
      2011 International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      名古屋大学(愛知県)
    • Year and Date
      2011-11-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of the mechanical properties of substrates on the in vitro formation of bile ducts by biliary epithelial cells2011

    • Author(s)
      Ryo Sudo, Kaoru Matsuo, Tomoya Komatsu, Mariko Ikeda, Toshihiro Mitaka, Kazuo Tanishita
    • Organizer
      International Symposium on Mechanobiology
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] マイクロ流体デバイスを用いた三次元組織の再生2011

    • Author(s)
      須藤亮
    • Organizer
      東京大学マイクロ・ナノ多機能デバイス研究ネットワーク第3回シンポジウム
    • Place of Presentation
      神奈川
    • Year and Date
      2011-07-04
    • Related Report
      2011 Final Research Report
  • [Presentation] マイクロ流体デバイスを用いた三次元組織の再生2011

    • Author(s)
      須藤亮
    • Organizer
      東京大学マイクロ・ナノ多機能デバイス研究ネットワーク第3回シンポジウム
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Year and Date
      2011-07-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microfluidic hydrostatic deposition patterning for investigating hepatocyte-biliary epithelial cell interactions2011

    • Author(s)
      Yuyang Lee, Ryo Sudo, Tomoya Komatsu, Toshihiro Mitaka, Mariko Ikeda, Kazuo Tanishita
    • Organizer
      日本生体医工学会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Microfluidic Hydrostatic Deposition Patterning for investigatinghepatocyte-biliary epithelial cell interactions2011

    • Author(s)
      Yuyang Lee
    • Organizer
      日本生体医工学会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胆管様ネットワーク再形成に関する組織工学2010

    • Author(s)
      谷下一夫、須藤亮
    • Organizer
      胆道閉鎖症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 胆管様ネットワーク再形成に関する組織工学2010

    • Author(s)
      谷下一夫、須藤亮
    • Organizer
      胆道閉鎖症研究会
    • Place of Presentation
      慶應義塾大学三田キャンパス(東京都)
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] A bioengieering approach to liver tissue engineering2010

    • Author(s)
      Ryo Sudo
    • Organizer
      Biofrontier Symposium 2010
    • Place of Presentation
      石川
    • Year and Date
      2010-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] A Bioengineering Approach to Liver Tissue Engineering2010

    • Author(s)
      Ryo Sudo
    • Organizer
      Biofrontier Syposium 2010
    • Place of Presentation
      IT Business Plaza Musashi (石川県)
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of extracellular matrix stiffness on ductular formation of biliary epithelial cells2010

    • Author(s)
      Tomoya Komatsu, Ryo Sudo, Toshihiro Mitaka, Mariko Ikeda, Kazuo Tasnihita
    • Organizer
      6^<th> World Congress of Biomechanics
    • Place of Presentation
      Singapore
    • Year and Date
      2010-08-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of Extracellular Matrix Stiffness on Ductular Formation of Biliary Epithelial Cells2010

    • Author(s)
      Tomoya Komatsu
    • Organizer
      World Congress of Biomechanics 2010
    • Place of Presentation
      Suntec Convention Centre (Singapore)
    • Year and Date
      2010-08-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] PLGA membrane sandwich culture model of biliary epithelial cells for reconstruction of bile duct2010

    • Author(s)
      Kaoru Matsuo, Tomoya Komatsu, Toshiro Mitaka, Mariko Ikeda, Ryo Sudo, Kazuo Tanishita
    • Organizer
      第49回日本生体医工学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] PLGA membrane sandwich culture model of biliary epithelial cells for reconstruction of bile duct2010

    • Author(s)
      松尾薫
    • Organizer
      日本生体医工学会
    • Place of Presentation
      大阪国際交流センター(大阪府)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体吸収性薄膜による胆管上皮細胞の管腔構造形成2010

    • Author(s)
      松尾薫、小松那也、三高俊広、池田満里子、須藤亮、谷下一夫
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Year and Date
      2010-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体吸収性薄膜による胆管上皮細胞の管腔構造形成2010

    • Author(s)
      松尾薫
    • Organizer
      肝細胞研究会
    • Place of Presentation
      秋田アトリオン(秋田県)
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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