Innovative method of combined hepatic tissue regeneration by the connection of bile canaliculi and bile ducts
| Project/Area Number |
22650106
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Keio University |
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Principal Investigator |
SUDO Ryo 慶應義塾大学, 理工学部, 講師 (20407141)
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| Co-Investigator(Kenkyū-buntansha) |
TANISHITA Kazuo 慶應義塾大学, 理工学部, 教授 (10101776)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Mariko 慶應義塾大学, 理工学部, 名誉教授 (00051368)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,130,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 人工臓器工学 / 再生医工学 / 胆管上皮細胞 |
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| Research Abstract |
The purpose of this study is to reconstruct a combined hepatic tissue by controlling oxygen concentration and elasticity in cellular microenvironments. Specifically, we aimed to combine bile canaliculi, which are formed by hepatocytes, and bile ducts, which are formed by biliary epithelial cells. Oxygen concentration was controlled using an oxygen permeable silicone membrane while elasticity was controlled by changing the elasticity of collagen gel that is a cellular scaffold. We found that oxygen concentration around cells is an important regulatory factor for combining bile ducts and bile canaliculi.
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Report
(3 results)
Research Products
(23 results)
