Development of Radiation-Activatable Nanoparticles Conjugated with Antitumor Prodrugs
| Project/Area Number |
22650109
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University |
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Principal Investigator |
ITO Takeo 京都大学, 大学院・工学研究科, 助教 (80378801)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMOTO Sei-ichi 京都大学, 大学院・工学研究科, 教授 (10115909)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ナノバイオ材料 / ナノ粒子 / 放射線活性化型 / 低酸素腫瘍細胞 / 水和電子 / ドラッグデリバリーシステム / 放射線活性化 |
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| Research Abstract |
Photo-or Radiation-induced activation of antitumor prodrugs in the hypoxic regions around solid tumor tissues has attained much interest in the past decade. In this study, we prepared gold nanoparticles conjugated with photo-or radiation-activatable prodrugs with the Au-S bond. Quantification of released antitumor agent of cytarabine after hypoxic X-ray irradiation in the presence of various radical scavengers suggested that the reaction proceeds via reduction by hydrated electrons.
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Report
(3 results)
Research Products
(22 results)
