Development of a novel charged-particle therapy combined with effects of tumor blood flow interruption
Project/Area Number |
22650113
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Medical systems
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Research Institution | Tohoku University |
Principal Investigator |
TERAKAWA Atsuki 東北大学, 大学院・工学研究科, 准教授 (10250854)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,390,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
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Keywords | 粒子線治療 / 腫瘍血流遮断剤 / 超高分解能PET / 陽子線治療 / 腫瘍血流遮断薬 / PET |
Research Abstract |
Therapeutic experiments were performed based on a murine solid tumor to develop a novel combined-treatment between proton therapy and a vascular disrupting agent AVE8062. Therapeutic effects on tumor growth were evaluated from high spatial resolution PET using [18F] Fluoro-Deoxy-Glucose and [18F] Fluoromisonidazole. The results of the PET scans show that a single combined treatment between proton therapy and AVE8062 caused extensive necrosis in the inner region of the tumor, while tumor cells in the tumor periphery survived the single treatment. It is suggested that the tumor receiving the single combined-treatment can be cured after the second proton irradiation.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR TREATED WITH A VASCULAR DISRUPTING AGENT AVE80622011
Author(s)
A. TERAKAWA, K. ISHII, S. MATSUYAMA, Y. KIKUCHI, S. YASUNAGA, Y. ITO, A. TAGAWA, T. KAWAMURA, Y. TAKAHASHI, Y. HATORI, N. HAMADA, K. FUJIKI, Y. MIURA, H. YAMAZAKI, Y. FUNAKI, S. FURUMOTO, N. ITO, S. WADA, and K. SERA
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Journal Title
International Journal of PIXE
Volume: Vol.21 Nos. 3 & 4
Pages: 125-131
Related Report
Peer Reviewed
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[Journal Article] PIXE analysis of a murine solid tumor treated with proton therapy combined with cisplatin2011
Author(s)
A. Terakawa, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Ito, A. Tagawa, S. Yasunaga, T. Kawamura, Y. Takahashi, Y. Hatori, N. Hamada, K. Fujiki, N. Ito, S. Wada, Y. Funaki and K. Sera
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Journal Title
X-RAY Spectrometry
Volume: 40
Pages: 198-201
Related Report
Peer Reviewed
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[Journal Article] PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR FOR PROTON THERAPY COMBINED WITH THE CHEMOTHERAPEUTIC AGENT CISPLATIN2010
Author(s)
A. TERAKAWA, Y. ITO, K. ISHII, S. MATSUYAMA, Y. KIKUCHI, S. YASUNAGA, A. TAGAWA, T. KAWAMURA, Y. TAKAHASHI, Y. HATORI, N. HAMADA, K. FUJIKI, H. YAMAZAKI, Y. FUNAKI, N. ITO, S. WADA, K. SERA
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Journal Title
International Journal of PIXE
Volume: Vol.20 Nos. 3 & 4
Pages: 85-91
Related Report
Peer Reviewed
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[Journal Article] Development of an adjustable beam flattening system for modification of passive beam delivery technique in proton therapy2010
Author(s)
A. Esmaili Torshabi, A. Terakawa, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, H. Akiyama, K. Koyata, A. Tagawa, Y. Itoh, S. Yasunaga
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Journal Title
Nuclear Instruments and Methods in Physics Research
Volume: A 615
Pages: 138-141
Related Report
Peer Reviewed
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