Research Project
Grant-in-Aid for Challenging Exploratory Research
Therapeutic experiments were performed based on a murine solid tumor to develop a novel combined-treatment between proton therapy and a vascular disrupting agent AVE8062. Therapeutic effects on tumor growth were evaluated from high spatial resolution PET using [18F] Fluoro-Deoxy-Glucose and [18F] Fluoromisonidazole. The results of the PET scans show that a single combined treatment between proton therapy and AVE8062 caused extensive necrosis in the inner region of the tumor, while tumor cells in the tumor periphery survived the single treatment. It is suggested that the tumor receiving the single combined-treatment can be cured after the second proton irradiation.
All 2011 2010
All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (7 results)
International Journal of PIXE
Volume: Vol.21 Nos. 3 & 4 Pages: 125-131
X-RAY Spectrometry
Volume: 40 Pages: 198-201
Volume: Vol.21,Nos.3 & 4 Issue: 03n04 Pages: 125-131
10.1142/s0129083511002240
Volume: (未定)(掲載確定)
Volume: Vol.20 Nos. 3 & 4 Pages: 85-91
Nuclear Instruments and Methods in Physics Research
Volume: A 615 Pages: 138-141
Volume: 20, No 3&4 Pages: 85-91
