| Project/Area Number |
22650120
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|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical systems
|
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| Research Institution | Fukuoka University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
LORETOB Feril 福岡大学, 医学部, 講師 (10435109)
ENDO Hitomi 福岡大学, 医学部, 講師 (00435108)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,330,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Keywords | 超音波 / 酸化チタン / がん治療 |
|---|
| Research Abstract |
Sonodynamic therapy is a new modality using ultrasound(US) to activate certain chemical sensitizers for cancer therapy. In this study, the effect of US combined with a nanoparticle titanium dioxide(TiO2) on melanoma cell was investigated in vitro and in vivo. The cell viability was significantly decreased only after US irradiation in the presence of TiO2.In vivo results showed significant inhibition of tumor growth in groups treated with TiO2 and US.
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