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Etiology and pathophysiology of experimental heterotopic ossification in the spinal cord injury model mouse

Research Project

Project/Area Number 22650126
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNagoya University

Principal Investigator

KAWAMURA Morio  名古屋大学, 医学系研究科(保健), 教授 (30186150)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords異所性骨化 / 骨形成因子 / 脊髄損傷 / 動物モデル / 炎症反応 / 免疫染色 / 脊椎損傷 / 運動負荷
Research Abstract

For the purpose of clarification of patho-physiology of heterotopic ossification, we investigated the state of new bone formation, which was induced by bone morphogenetic protein, in the spinal cord injury model mouse. In the spinal cord injury mouse group, the more significant new bone formation was recognized than in the no injury mouse group. There was no difference in new bone formation between the complete and incomplete spinal cord injury mouse group. When we imposed passive enforced flexion and extension movement on the knee joint of spinal cord injury mouse, the heavy enforcement group showed more volume of new bone formation than no passive movement group. There was no difference of new bone formation between heavy and light enforcement group. And also there was no difference of new bone formation between light enforcement group and no passive movement group. In the patho-histological study, the dense inflammatory reaction was recognized around the bone morphogenetic protein powder in the early phase of implantation. It was suggested the spinal cord injury, enforced passive movement and inflammatory reaction influenced on the etiology of heterotopic ossification.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (3 results) Presentation (4 results)

  • [Journal Article] 脊髄損傷モデルマウスに対する他動運動が実験的異所性骨化に及ぼす影響2012

    • Author(s)
      村瀬一馬、河村守雄
    • Journal Title

      名古屋大学大学院・医学系研究科リハビリテーション療法学専攻修士論文

      Pages: 1-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] 脊髄損傷モデルマウスに対する他動運動が実験的異所性骨化に及ぼす影響2012

    • Author(s)
      村瀬数馬
    • Journal Title

      名古屋大学大学院前期課程修士論文

      Volume: 1 Pages: 1-14

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 脊髄損傷モデルマウスにおける麻痺の程度と骨形成量について-peak-out 現象への対応-2010

    • Author(s)
      村瀬数馬、河村守雄
    • Journal Title

      名古屋大学医学部保健学科理学療法学専攻学士論文集

      Volume: 第9巻 Pages: 1-8

    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄損傷モデルマウスにおける麻痺の程度と異所性骨化による骨形成量2012

    • Author(s)
      村瀬数馬(代表)、河村守雄、勝水健吾
    • Organizer
      第45回日本理学療法士会学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2012-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] The effect of passive movement on heterotopic ossification in experimentalmodel mice of spinal cord injury2011

    • Author(s)
      K. Murase and M. Kawamura
    • Organizer
      2011Yonsei-Nagoya University Research Exchange Meetings
    • Place of Presentation
      韓国原州市
    • Year and Date
      2011-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] The effect of passive movement on heterotopic ossification in experimental model mice of spinal cord injury2011

    • Author(s)
      K.Murase, M.Kawamura
    • Organizer
      2011 Yonsei-Nagoya University Research Exchange Meetings
    • Place of Presentation
      韓国原州市
    • Year and Date
      2011-11-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脊髄損傷モデルマウスにおける実験的異所性骨化の成因と病態の研究2011

    • Author(s)
      村瀬数馬、河村守雄、勝水健吾
    • Organizer
      第45回日本理学療法士会学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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