Construction of nerve cell body on a 3-dimensional culture device
| Project/Area Number |
22650127
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | 独立行政法人国立成育医療研究センター (2011)
National Center for Geriatrics and Gerontology (2010) |
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Principal Investigator |
MIYAMOTO Yoshitaka 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 共同研究員 (20425705)
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| Co-Investigator(Kenkyū-buntansha) |
IKEUCHI Masashi 東京大学, 先端科学技術研究センター, 助教 (90377820)
KAJI Noritada 名古屋大学, 工学系・研究科, 准教授 (90402479)
YAGI Tohru 東京工業大学, 情報理工学研究科, 准教授 (90291096)
HAYASHI Shuji 名古屋大学, 医学系・研究科, 寄附講座教授 (30218573)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 脳・神経 / マイクロ・ナノデバイス / 細胞・組織 |
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| Research Abstract |
This study aims to develop a device for the construction of three dimensional cell assemblies of nerve-like cells. The device for cell patterning has enabled to generate cell assemblies with a controlled size in large numbers and to simultaneously evaluate their functions under various culture conditions. The size of the tissues was controlled for primary cells, tissue-derived stem cells, and induced plulipotent stem(iPS) cells. The cell assemblies on the device had their drug response, and protein level analysis revealed their some functions. The 2D culture of nerve-like cells also showed that a neural-like network was generated on the device and cyclic response to electric nerve stimulation was changed.
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Report
(3 results)
Research Products
(36 results)
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[Presentation] Toxicity and functional assessment using polysaccharide-based magnetic iron oxide nanoparticles for cell labeling in cell array system2010
Author(s)
Miyamoto Y, Koshidaka Y, Saito H, Kagami Y, Murase K, Kaji N, Yukawa H, Noguchi H, Iwata H, Ikeya T, Baba Y, Hayashi S
Organizer
2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010), New Aspects of Chemical Glycobiology toward Development of new Diagnostics and Therapeutics Symposium
Place of Presentation
Hawaii Convention Center (Honolulu, Hawaii, USA)
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