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Effects of medullary raphe nuclei lesions during developmental stageon sleep

Research Project

Project/Area Number 22650141
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Physical education
Research InstitutionTottori University

Principal Investigator

HOSOGAI Masae  鳥取大学, 医学部, 助教 (50032206)

Co-Investigator(Kenkyū-buntansha) MATSUO Satoshi  鳥取大学, 医学部, 准教授 (40219390)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,280,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords身体システム学 / 延髄縫線核 / 睡眠 / 発達 / ラット / 呼吸筋活動 / カイニン酸 / 無呼吸 / 呼吸筋活 / 心電図 / 脳波
Research Abstract

Midline raphe nuclei of the brainstem have been implicated in motor function, sensory processing, autonomic neural control systems and memory. They have also played an important role in sleep. The present study was undertaken to investigateeffects of kainic acid injection into the medullary raphe nuclei of young and adult raton respiration. We also examined effect of the lesion during development on sleep.The chemical lesions of adult rat induced a transient increase in frequency of respiration, and the frequency subsequently decreased. Then, apnea was elicited. After the lesion of the medullary raphe nuclei during developing periods, the rats had light sleep compare to normal adult rats. These results suggest that lesions of medullary raphe nuclei by kainic acid change respiratory movement. Medullary raphe lesionsduring developing periods in rats also affect sleep patterns

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] Involvement of the medullary raphe nuclei in the control of respiration2013

    • Author(s)
      Masae Hosogai, Satoshi Matsuo:
    • Journal Title

      The Journal of Physiological Sciences

      Volume: Vol. 63

    • Related Report
      2012 Final Research Report
  • [Journal Article] Involvement of the medullary raphe nuclei in the control of respiration2013

    • Author(s)
      Masae Hosogai, Satoshi Matsuo
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 63

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Respiratory changes after lesions of the medullary raphe nuclei2013

    • Author(s)
      Masae Hosogai, Satoshi Matsuo
    • Journal Title

      Clinical Neurophysiology

      Volume: 電子版

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of medullary raphe nuclei lesions in rats on breathing2012

    • Author(s)
      Masae Hosogai, Satoshi Matsuo:
    • Journal Title

      The Journal of Physiological Sciences

      Volume: Vol. 62

    • Related Report
      2012 Final Research Report
  • [Journal Article] 延髄縫線核の傷害による呼吸運動の変化2012

    • Author(s)
      細貝正江、松尾 聡
    • Journal Title

      臨床神経生理学

      Volume: 第40巻、第5号 Pages: 470-470

    • Related Report
      2012 Final Research Report
  • [Journal Article] 延髄縫線核の障害による呼吸運動の変化2012

    • Author(s)
      細貝正江、松尾 聡
    • Journal Title

      臨床神経生理学

      Volume: 40 Pages: 470-470

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Effects of medullary raphe nuclei lesions in rats on breathing2012

    • Author(s)
      Masae Hosogai, Satoshi Matsuo
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 62

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Properties of respiratory neurons in medullary raphe nuclei of rats2011

    • Author(s)
      Masae Hosogai, Satoshi Matsuo
    • Journal Title

      Neuroscience Research

      Volume: Vol. 71

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 呼吸運動に対する延髄縫線核の関与2013

    • Author(s)
      細貝正江、松尾 聡
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2013-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 呼吸運動に対する延髄縫線核の関与2013

    • Author(s)
      細貝正江
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船掘(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 延髄縫線核の傷害による呼吸運動の変化2012

    • Author(s)
      細貝正江、松尾 聡
    • Organizer
      第42回日本臨床神経生理学会学術大会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 延髄縫線核へのカイニン酸注入が呼吸に及ぼす影響2012

    • Author(s)
      細貝正江、松尾 聡
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット延髄縫線核の傷害が呼吸に及ぼす影響2012

    • Author(s)
      細貝正江、松尾 聡
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市総合体育館(松本市)
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット延髄縫線核の傷害が呼吸に及ぼす影響2012

    • Author(s)
      細貝正江
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本市総合体育館(松本市)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 延髄縫線核の傷害による呼吸運動の変化2012

    • Author(s)
      細貝正江
    • Organizer
      第42回日本臨床神経生理学会学術大会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 延髄縫線核へのカイニン酸注入が呼吸に及ぼす影響2012

    • Author(s)
      細貝正江
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラット延髄縫線核呼吸性ニューロン2011

    • Author(s)
      細貝正江、松尾 聡
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report 2011 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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