Promotion of neuromuscular regeneration by transplantation of bone marrow and/ or muscle satellite cells

• Project/Area Number: 22650153
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Osaka University
• Principal Investigator: OHIRA Yoshinobu 大阪大学, 医学系・研究科, 教授 (50185378)
• Co-Investigator(Kenkyū-buntansha): NAKAI Naoya 大阪大学, 医学系・研究科, 准教授 (90324508) ; KAWANO Fuminori 大阪大学, 医学系・研究科, 助教 (90346156)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,330,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 筋再生 / 神経再生 / サイトカイン / プロテオミクス / 温熱刺激 / 筋活動 / 脳機能 / 感覚神経

Research Abstract

Effects of transplantation of bone marrow and/ or muscle satellite cells with enhanced expression of heat shock protein 72(HSP72) on the regeneration of muscle and nerve were studied. These cells sampled from green mice were transplanted i. p. or i. v. through the jugular vein to mouse with hindlimb muscle injury caused by intramuscular injection of bupivacaine. The transplanted cells were detected in the injured muscle, not in the contralateral intact muscle. Effects of such treatment for promotion of regeneration were not clear due to the rejection of transplanted cells by the recipient mouse. However, it was suggested that beneficial effects of cell transplantation according to the analyses of morphological properties of muscle cross-section and gene expression.

Research Products

• [Journal Article] HSP25 can modulate myofiber desmin cytoskeleton following the phosphorylation at Ser15 in rat soleus muscle (2012)
  • Author(s): Kawano, F., R. Fujita, N. Nakai, M. Terada, T. Ohira, and Y. Ohira
  • Journal Title: J. Appl. Physiol Volume: 112 Pages: 176-186
• [Journal Article] Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier (2012)
  • Author(s): Arima, Y., M. Harada, D. kamimura, J-H. Park, F. Kawano, F. E. Yull. T. Kawamoto, Y. Iwakura, U. A. K. Betz, G. Marquez, T. S. Blackwell, Y. Ohira, T. Hirano, and M. Murakami
  • Journal Title: Cell Volume: 148 Pages: 447-457
• [Journal Article] Biomedical analysis of rat body hair after hindlimb suspension for 14 days (2012)
  • Author(s): Terada, M., F. Kawano, N. Ishioka, A. Higashibata, H. J. Majima, T. Yamazaki, T. Watanabe-Asaka, M. Niihori, R. Nakano, S. Yamada, C. Mukai, and Y. Ohira
  • Journal Title: Acta Astronautica Volume: 73 Pages: 23-29
• [Journal Article] Effects of hindlimb unloading on neurogenesis in the hippocampus of newly weaned rats (2012)
  • Author(s): Nomura, S., K. Kami, F. Kawano, Y. Oke, N. Nakai, T. Ohira, R. Fujita, M. Terada, K. Imaizumi, and Y. Ohira
  • Journal Title: Neurosci. Lett Volume: 509 Pages: 76-81
• [Journal Article] Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission (2012)
  • Author(s): Sandona, D., J.-F. Desaphy, G. M. Camerino, E. Bianchini, S. Ciciliot, D. Danieli-Betto, G. Dobrowolny, S. Furlan, E. Germinario, K. Goto, M. Gutsmann, F. Kawano, N. Nakai, T. Ohira, Y. Ohno, A. Picard, M. Salanova, G. Schiffl, D. Blottner, A. Musaro, Y. Ohira, R. Betto, D. Conte, and S. Schiaffino
  • Journal Title: PloS ONE Volume: 7
• [Journal Article] Ambesi-Impiombato. The impact of long-term exposure to space environment on adult mammalian organisms : a study on mouse thyroid and testis (2012)
  • Author(s): Masini, M. A., E. Albi, C. Barmo, T. Bonfiglio, L. Bruni, L. Canesi, S. Cataldi, F. Curcio, M. D' Amora, I. Ferri, K. Goto, F. Kawano, R. Lazzarini, E. Loreti, N. Nakai, T. Ohira, Y. Ohira, S. Palmero, P. Prato, F. Ricci, L. Scarabelli, T. Shibaguchi, R. Spelat, F. Strollo, and F. S.
  • Journal Title: PloS ONE Volume: 7
• [Journal Article] Responses of muscle mass, strength and gene expressions to long-term heat stress in healthy human subjects (2011)
  • Author(s): Goto, K., H. Oda, H. Kondo, M. Igaki, A. Suzuki, S. Tsuchiya, T. Murase, T. Hase, H. Fujiya, I. Matsumoto, H. Naito, T. Sugiura, Y. Ohira, and T. Yoshioka
  • Journal Title: Eur. J. Appl. Physiol Volume: 111 Pages: 17-27
• [Journal Article] Possible role of NF-. B signals in heat stress-associated increase in protein content of cultured C2C12 cells (2011)
  • Author(s): Ohno, Y., S. Yamada, T. Sugiura, Y. Ohira, T. Yoshioka, and K. Goto.
  • Journal Title: Cells Tissues Organs Volume: 194 Pages: 363-370
• [Journal Article] Effects of creatine and its analog,β-guanidinopropionic acid, on the differentiation and nucleoli in myoblasts (2011)
  • Author(s): Ohira, Y., Y. Matsuoka, F. Kawano, A. Ogura, Y. Higo, T. Ohira, M. Terada, Y. Oke, and N. Nakai
  • Journal Title: Biosci. Biotechnol. Biochem Volume: 75 Pages: 1085-1089
  • NAID: 10029327954
• [Journal Article] Region-specific responses of adductor longus muscle to gravitational load-dependent activity in Wistar Hannover rats (2011)
  • Author(s): Ohira, T., X. D. Wang, M. Terada, F. Kawano, N. Nakai, A. Ogura, and Y. Ohira.
  • Journal Title: PLoS ONE Volume: 6
• [Journal Article] Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice (2011)
  • Author(s): Yasuhara, K., Y. Ohno, A. Kojima, K. Uehara, M. Beppu, T. Sugiura, M. Fujimoto, A. Nakai, Y. Ohira, T. Yoshioka, and K. Goto
  • Journal Title: J. Appl. Physiol Volume: 111 Pages: 1142-1149
• [Journal Article] 3ヶ月の宇宙基地滞在がマウスの生理学的特性に及ぼす影響:宇宙実験のコントロールとしての地上シミュレーション実験 (2011)
  • Author(s): 大平充宣、中井直也、河野史倫、大平宇志、芝口翼、藤田諒、後藤勝正、石原昭彦、大石康晴、山崎将生、向井千秋、寺田昌弘、山下雅道、宇佐美眞一、奥野誠、落合俊昌、行徳淳一郎
  • Journal Title: Space Utiliz. Res. Volume: 27 Pages: 122-123
  • NAID: 120006830349
• [Journal Article] 哺乳類小動物を用いた宇宙生物学実験 (2011)
  • Author(s): 山崎将生、大平充宣、奥野誠、石原昭彦、清水強、粂井康宏、伊藤康宏、野村裕子、高林彰、大西武雄、片平清昭、矢野昭起、中野完、山下雅道
  • Journal Title: Space Utiliz. Res. Volume: 27 Pages: 124-126
• [Journal Article] 宇宙環境での疾病と健康管理-2010年(第1年度)研究チーム活動報告- (2011)
  • Author(s): 石原昭彦、津田謹輔、神埼素樹、永友文子、藤野英己、平田総一郎、三浦靖史、村上慎一郎、近藤浩代、武田功、大平充宣
  • Journal Title: Space Utiliz. Res. Volume: 27 Pages: 142-144
• [Journal Article] 月・火星表面等のPartial Gravity環境における生命科学研究:平成22年度研究班WG活動 (2011)
  • Author(s): 粂井康宏、粟生修司、跡見順子、五十嵐眞、井上カタジナ、石岡憲昭、石田宝義、伊藤雅夫、山下雅道、岩崎賢一、大平充宣、奥野誠、景山大郎、河野史倫、木崎昌弘、長谷川克也、Jorge Zeredo、戸田一雄、野村泰之、松浦正明、向井千秋、森田定雄、薮下忠親、秋山英雄、若田光一
  • Journal Title: Space Utiliz. Res. Volume: 27 Pages: 201-202
  • NAID: 120006830379
• [Journal Article] 尾部懸垂の精子形成における影響 (2011)
  • Author(s): 奥野誠、向井千夏、大平充宣
  • Journal Title: Space Utiliz. Res. Volume: 27 Pages: 203-204
  • NAID: 120006830380
• [Journal Article] 発育期の脚運動がラット脳の発育・発達に及ぼす影響 (2011)
  • Author(s): 大平充宣、野村幸子、尾家慶彦、大平宇志、河野史倫、藤田諒、中井直也、今泉和彦
  • Journal Title: 早稲田大学人間科学学術院「人間科学研究」 Volume: 第23巻第1号補遺号 Pages: 127-127
  • NAID: 120005260316
• [Journal Article] 健康の維持・増進を目指した運動処方のヒトおよびラットにおける再検討 (2011)
  • Author(s): 大平充宣、中井直也、岡部洋興、陳全寿
  • Journal Title: デサントスポーツ科学 Volume: 32 Pages: 11-18
  • NAID: 40018886187
• [Journal Article] 筋機能からみた萎縮と肥大のメカニズム (2011)
  • Author(s): 後藤勝正、大平充宣
  • Journal Title: 体育の科学別冊 Volume: 61(12) Pages: 900-906
• [Journal Article] Responses of muscle mass, strength and gene expressions to long-term heat stress in healthy human subjects (2011)
  • Author(s): Goto, K., H.Oda, H.Kondo, M.Igaki, A.Suzuki, S.Tsuchiya, T.Murase, T.Hase, H.Fujiya, I.Matsumoto, H.Naito, T.Sugiura, Y.Ohira, T.Yoshioka
  • Journal Title: Eur.J.Appl.Physiol. Volume: 111 Pages: 17-27
  • Peer Reviewed
• [Journal Article] Possible role of NF-κB signals in heat stress-associated increase in protein content of cultured C2C12 cells (2011)
  • Author(s): Ohno, Y., S.Yamada, T.Sugiura, Y.Ohira, T.Yoshioka, K.Goto
  • Journal Title: Cells Tissues Organs Volume: 194 Pages: 363-370
  • Peer Reviewed
• [Journal Article] Myonucleus-related properties in soleus muscle fibers of mdx mice (2010)
  • Author(s): Terada, M., Y. B. Lan. F. Kawano, T. Ohira, Y. Higo, N. Nakai, K. Imaizumi, A. Ogura, N. Nishimoto, Y. Adachi, and Y. Ohira
  • Journal Title: Cells Tissues Organs Volume: 191 Pages: 248-259
• [Journal Article] Role(s) of gravitational loading during developing period on the growth of rat soleus muscle fibers (2010)
  • Author(s): Kawano, F., K. Goto, X. D. Wang, M. Terada, T. Ohira, N. Nakai, T. Yoshioka, and Y. Ohira
  • Journal Title: J. Appl. Physiol Volume: 108 Pages: 676-685
• [Journal Article] A possible role of NF-К_B and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats (2010)
  • Author(s): Ohno, Y., S. Yamada, T. Sugiura, Y. Ohira, T. Yoshioka, and K. Goto
  • Journal Title: Gen. Physiol. Biophys Volume: 29 Pages: 234-242
• [Journal Article] Role(s) of mechanical load and satellite cells in the regulation of the size of soleus muscle fiber in rats (2010)
  • Author(s): Ohira, Y., F. Kawano, X. D. Wang, N. Nakai, T. Ohira, H. Okabe, H. Naito, and K. Goto
  • Journal Title: Biol. Sci. Space Volume: 24 Pages: 135-144
  • NAID: 10029277900
• [Journal Article] Mechanical stretch activates signaling events for protein translation initiation and elongation in C2C12 myoblasts (2010)
  • Author(s): Nakai, N., F. Kawano, Y. Oke, S. Nomura, T. Ohira, R. Fujita, and Y. Ohira
  • Journal Title: Mol. Cells Volume: 30 Pages: 513-518
• [Journal Article] 哺乳類小動物を用いた宇宙生物学実験-Working Group2009年度報告- (2010)
  • Author(s): 山崎将生、石原昭彦、奥野誠、粂井康弘、清水強、矢野昭起、跡見順子、大西武雄、大平充宣、片平清昭、中野完、山下雅道
  • Journal Title: Space Utiliz. Res. Volume: 26 Pages: 222-223
  • NAID: 120006830472
• [Journal Article] 哺乳動物および魚類の発育・発達における重力ン役割追求研究班報告:イタリア宇宙機関によるmouse drawer system利用の宇宙実験 (2010)
  • Author(s): 大平充宣、中井直也、河野史倫、大平宇志、藤田諒、後藤勝正、石原昭彦、大石康晴、山崎将生、向井千秋、寺田昌弘、山下雅道、落合俊昌、行徳淳一郎
  • Journal Title: Space Utiliz. Res. Volume: 26 Pages: 224-225
• [Journal Article] 月・火星表面等のPartial Gravity環境における生命科学研究: WG活動報告 (2010)
  • Author(s): 粂井康宏、岩崎賢一、戸田一雄、秋山英雄、大平充宣、野村康之、跡見順子、奥野誠、松浦正明、大谷啓一、景山大郎、向井千秋、井上カタジナ、河野史倫、森田定雄、石岡憲昭、木崎昌弘、薮下忠親、石田宝義、伊藤雅夫、山下雅道、若田光一、Jorge Zeredo
  • Journal Title: Space Utiliz. Res. Volume: 26 Pages: 226-227
  • NAID: 120006830474
• [Journal Article] 体位変換による血液分布の変化が運動能力に及ぼす影響:自転車エルゴメーター運動中の制限因子の検討 (2010)
  • Author(s): 川畑哲也、岡部洋興、大平宇志、河野史倫、内藤久士、大平充宣
  • Journal Title: 宇宙航空環境医学 Volume: 47 Pages: 15-22
  • NAID: 10029518929
• [Journal Article] Myonucleus-related properties in soleus muscle fibers of mdx mice. (2010)
  • Author(s): Terada M., et al.
  • Journal Title: Cell Tissues Organs Volume: 191 Pages: 248-259
  • Peer Reviewed
• [Journal Article] A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats (2010)
  • Author(s): Ohno, Y., et al.
  • Journal Title: Gen.Physiol.Biophys. Volume: 29 Pages: 234-242
  • Peer Reviewed
• [Journal Article] Role(s) of gravitational loading during developing period on the growth of rat soleus muscle fibers (2010)
  • Author(s): Kawano, F., et al.
  • Journal Title: J.Appl.Physiol. Volume: 108 Pages: 676-685
  • Peer Reviewed
• [Journal Article] Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days
  • Author(s): Santucci, D., F. Kawano, T. Ohira, M. Terada, N. Nakai, N. Francia, E. Alleva, L. Aloe, T. Ochiai, R. Cancedda, K. Goto, and Y. Ohira.
  • Journal Title: PLoS ONE Volume: (in press)
• [Journal Article] Regulation of soleus muscle properties by mechanical stress and/ or neural acrivity
  • Author(s): Kawano, F., N. Nakai, and Y. Ohira.
  • Journal Title: J. Phys. Fit. Sports Med.(Review) Volume: (in press)
• [Journal Article] Some aspects of heat stress on the plasticity of skeletal muscle cells
  • Author(s): Goto, K., Y. Ohno, A. Goto, A. Ikuta, M. Suzuki, T. Ohira, N. Tsuchiya, S. Nishizawa, T. Koya, T. Egawa, T. Sugiura, Y. Ohira, and T. Yoshioka, T.
  • Journal Title: J. Phys. Fit. Sports Med.(Review) Volume: (in press)
• [Journal Article] Control of muscle protein synthesis in response to exercise and amino acids
  • Author(s): Nakai, N., F. Kawano, and Y. Ohira
  • Journal Title: J. Phys. Fit. Sports Med.(Review) Volume: (in press)
  • NAID: 10031158957
• [Journal Article] Effects of inhibited antigravity muscle activity on the expression of hippocampal proteins in growing rats
  • Author(s): Oke, Y., F. Kawano, S. Nomura, T. Ohira, R. Fujita, M. Terada, T. Shibaguchi, N. Nakai, and Y. Ohira
  • Journal Title: Jpn. J. Aerosp. Envion. Med. Volume: (in press)
• [Journal Article] Responses of HSC70 expression in diencephalon to iron deficiency anemia in rats
  • Author(s): Kawano, F., Y. Oke, S. Nomura, R. Fujita, T. Ohira, N. Nakai, and Y. Ohira
  • Journal Title: J. Physiol. Sci. Volume: (in press)
  • NAID: 10030350860
• [Journal Article] Effects of mechanical over-loading on the properties of soleus muscle fibers, with or without damage, in wild type and mdx mice
  • Author(s): Terada, M., F. Kawano, T. Ohira, N. Nakai, N. Nishimoto, and Y. Ohira
  • Journal Title: PLoS ONE Volume: (in press)
• [Journal Article] Neuromuscular responses to spaceflight
  • Author(s): Ohira, Y., F. Kawano, T. Ohira, T. Ohira, H. Okabe, H. Naito, K. Goto, and A. Ishihara
  • Journal Title: J. Gravit. Physiol.(Review) Volume: (in press)
• [Journal Article] Neuromuscular responses to spaceflight
  • Author(s): Ohira, Y., F.Kawano, T.Ohira, T.Ohira, H.Okabe, H.Naito, K.Goto, A.Ishihara
  • Journal Title: J.Gravit.Physiol. Volume: (In press)
  • Peer Reviewed
• [Presentation] Recording of neuromuscular activities of rats in a real microgravity environment using telemetry system (2012)
  • Author(s): Kawano, F., T. Ohira, T. Ochiai, and Y. Ohira
  • Organizer: Next-generation suborbital researchers conference
  • Place of Presentation: CA, USA
• [Presentation] Expectation for suborbital flight as life science experiment opportunity (2012)
  • Author(s): Ochiai, T., H. Murase, and Y. Ohira
  • Organizer: Next-generation suborbital researchers conference
  • Place of Presentation: CA, USA
• [Presentation] How does carp fish tilt the body in response to light under microgravity environment (2012)
  • Author(s): Ohira, T., T. Shibaguchi, T. Ohira, M. Yamada, F. Kawano, A. Takabayashi, T. Ochiai, and Y. Ohira
  • Organizer: Next-generation suborbital researchers conference
  • Place of Presentation: CA, USA
• [Presentation] Muscle-type dependent sarcolemmal NOS1 mislocalization following 91 days exposure to effective microgravity on. board the International Space Station(ISS) (2012)
  • Author(s): Salanova, M., R. Betto, D. Conte, D. Danieli-Betto, J-F. Desaphy, A. Musaro, Y. Ohira, D. Sandona, S. Schiaffino, and D. Blottner
  • Organizer: 39th COSPAR Scientific Assembly 2012
  • Place of Presentation: Mysore, India
• [Presentation] Up-regulation of heat shock proteins in-skeletal muscle of heat shock transcription factor 1-null mice (2011)
  • Author(s): Ohno, Y., K.Goto, T.Sugiura, Y.Ohira, T.Yoshioka
  • Organizer: 2011 ASGSB/ISGP Joint Conference, American Society for Gravitational and Space Biology (ASGSB) the 27^<th> Annual Meeting/International Society for Gravitational Physiology (ISGP) the 32^<nd> Annual Meeting
  • Place of Presentation: Anaheim, California, U.S.A.
  • Year and Date: 2011-11-04
• [Presentation] Effects of application of heat-stress for prevention of unloading-related atrophy and stimulation of recovery of skeletal muscle (2011)
  • Author(s): Yoshioka, T., K.Goto, T.Sugiura, Y.Ohira
  • Organizer: Space Forum-2011, Dedicated to the 50-th Anniversary of the First Human Space Flight by Yury Gagarin
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2011-10-07
• [Presentation] 抗重力活動抑制に対する骨格筋の形態的および代謝的特性の反応 (2011)
  • Author(s): 大平充宣
  • Organizer: 第88回日本生理学会大会、第116回日本解剖学会総会・全国学術集会、合同大会、シンポジウム「長期宇宙滞在が身体機能/形態に及ぼす影響」
  • Place of Presentation: 横浜
• [Presentation] 3ヶ月間の微小重力環境曝露へのマウス組織の反応: MDSプロジェクト (2011)
  • Author(s): 大平充宣
  • Organizer: 宇宙創薬協議会公開シンポジウム
  • Place of Presentation: 新宿住友スカイルーム、東京
• [Presentation] Expression of micro-RNA in mouse skeletal muscle after unloading and reloading (2011)
  • Author(s): Goto, K., Y. Ohno, A. Goto, A. Ikuta, K. Yasuhara, T. Sugiura, Y. Ohira, and T. Yoshioka
  • Organizer: The 7th Congress of the Federations of Asian and Oceanian Physiological Societies(FAOPS)
  • Place of Presentation: Taiwan
• [Presentation] Body tilting in response to gravity and/ or dorsal light response in carp fishes : roles of skeletal muscles and/ or fins (2011)
  • Author(s): Ohira, T., T. Shibaguchi, T. Ohira, M. Yamada, F. Kawano, A. Takabayashi, and Y. Ohira
  • Organizer: The 7th Congress of the Federations of Asian and Oceanian Physiological Societies(FAOPS)
  • Place of Presentation: Taiwan
• [Presentation] Effects of 3-month spaceflight on the characteristics of neck muscle in mice (2011)
  • Author(s): Ohira, T., T. Ohira, F. Kawano, T. Shibaguchi, R. Fujita, N. Nakai, K. Goto, H. Okabe, F. Ogita, T. Ochihai, R. Cancedda, and Y. Ohira
  • Organizer: The 7th Congress of the Federations of Asian and Oceanian Physiological Societies(FAOPS)
  • Place of Presentation: Taiwan
• [Presentation] Exercise prescription for stimulated mobilization of soleus muscle in human (2011)
  • Author(s): Okabe, H., T. Ohira, F. Kawano, Y. Oke, R. Fujita. T. Ohira, N. Nakai, and Y. Ohira
  • Organizer: The 7th Congress of the Federations of Asian and Oceanian Physiological Societies(FAOPS)
  • Place of Presentation: Taiwan
• [Presentation] Effects of 3-month exposure to real microgravity environment on epididymal sperm number in mice (2011)
  • Author(s): Shibaguchi, T., T. Ohira, R. Fujita, T. Ohira, F. Kawano, N. Nakai, K. Goto, H. Okabe, T. Ochiai, R. Cancedda, and Y. Ohira
  • Organizer: The 7th Congress of the Federations of Asian and Oceanian Physiological Societies(FAOPS)
  • Place of Presentation: Taiwan
• [Presentation] Effects of application of heat-stress for prevention of unloading-related atrophy and stimulation of recovery of skeletal muscle (2011)
  • Author(s): Yoshioka, T., K. Goto, T. Sugiura, and Y. Ohira
  • Organizer: Space Forum-2011, Dedicated to the 50-th Anniversary of the First Human Space Flight
  • Place of Presentation: Yury Gagarin
• [Presentation] Effects of 3-month-exposure to microgravity on microRNA expressions in mouse skeletal muscles (2011)
  • Author(s): Goto, K., Y. Ohno, F. Kawano, T. Ohira, R. Betto, S. Schiaffino, and Y. Ohira
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27th Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32nd Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Up-regulation of heat shock proteins in skeletal muscle of heat shock transcription factor 1-null mice (2011)
  • Author(s): Ohno, Y., K. Goto, T. Sugiura, Y. Ohira, and T. Yoshioka
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27th Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32nd Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] The MDS mission : adaptataion of skeletal muscle to long-term microgravity (2011)
  • Author(s): Desaphy, J. F., D. Sandona, G. M. Camerino, E. Bianchini, S. Ciciliot, D. Danieli-Betto, G. Dobrowolny, S. Furlan, E. Germinario, K. Goto, M. Gutsmann, F. Kawano, N. Nakai, T. Ohira, A. Picard, M. Salanova, G. Schiffl, A. Musaro, D. Blottner, Y. Ohira, R.
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27th Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32nd Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Adaptation of mouse brain, testis & epididymis, upper spinal cord, and hair roots to microgravity (2011)
  • Author(s): Ohira, Y., K. Goto, A. Ishihara, D. Santucci, M. A. Masini, T. Ochiai, R. Cancedda
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27th Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32nd Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Effects of long term space flight on erythrocytes and oxidative stress of mice (2011)
  • Author(s): Rizzo, A. M., G. Montorfano, P. Corsetto, S. Tavella, Y. Ohira, R. Cancedda, and B. Berra
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27th Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32nd Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Role of skeletal muscles and/ or fins during gravity-and/ or light-dependent body tilting in carp fishes (2011)
  • Author(s): Ohira, T., T. Shibaguchi, T. Ohira, M. Yamada, F. Kawano, A. Takabayashi, and Y. Ohira
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27th Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32nd Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Long-term exposure to real and simulated microgravity depresses the number of epididymal sperm in mice (2011)
  • Author(s): Shibaguchi, T., T. Ohira, F. Kawano, N. Nakai, K. Goto, T. Ochiai, and Y. Ohira
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27th Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32nd Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Limiting factor(s) during bicycle ergometer exercise in human subjects with altered blood distribution (2011)
  • Author(s): Okabe, H., T. Kawabata, T. Ohira, F. Kawano, H. Naito, and Y. Ohira
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27^<th> Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32^<nd> Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] The genetic analyses on body hair roots of space-flown mice as complement of human research (2011)
  • Author(s): Terada, M., R. Nakano, H. J. Majima, T. Yamazaki, A. Higashibata, N. Ishioka, and Y. Ohira
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27^<th> Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32^<nd> Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Micro-gravity experiment using meriones unguiculatus(Mongolian Gerbil) (2011)
  • Author(s): Ochiai, T., H. Murase, A. Homma, V. R. Edgerton, and Y. Ohira
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27^<th> Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32^<nd> Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Adiponectin expression of skeletal muscle in response to unloading and reloading in mice (2011)
  • Author(s): Goto, A., Y. Ohno, A. Ikuta, K. Goto, T. Sugiura, Y. Ohira, and T. Yoshioka
  • Organizer: 2011 ASGSB/ ISGP Joint Conference, American Society for Gravitational and Space Biology(ASGSB) the 27^<th> Annual Meeting/ International Society for Gravitational Physiology(ISGP) the 32^<nd> Annual Meeting
  • Place of Presentation: California, USA
• [Presentation] Effects of IL-6 receptor inhibition and/or heat treatment on the regeneration of injured mouse skeletal muscle (2010)
  • Author(s): Fujita R., et al.
  • Organizer: Experimental Biology meeting 2010
  • Place of Presentation: Anaheim, Calif., U.S.A.
  • Year and Date: 2010-04-25
• [Presentation] 宇宙環境におけるカウンタ-メジャ-としての運動 (2010)
  • Author(s): 大平充宣
  • Organizer: 第18回日本運動生理学会大会
  • Place of Presentation: 鹿児島大学
• [Presentation] ウィスターハノーバーラット後肢の抗重力活動抑制が長内転筋に及ぼす影響 (2010)
  • Author(s): 大平宇志、河野史倫、大平充宣
  • Organizer: 第56回日本宇宙航空環境医学会大会、研究奨励賞受賞講演
  • Place of Presentation: 埼玉
• [Presentation] 骨格筋の再生と再成長における荷重とミオスタチンの影響 (2010)
  • Author(s): 後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第87回日本生理学会大会シンポジウム「sophisticated organization of contractile apparatus in skeletal, cardiac and smooth muscles」
  • Place of Presentation: 岩手
• [Presentation] Reconsideration of exercise countermeasure for prevention of unloadeing-related atrophy in human soleus (2010)
  • Author(s): Ohira, Y., H. Okabe, T. Ohira, F. Kawano, Y. Oke, R. Fujita, S. Nomura, T. Ohira, and N. Nakai
  • Organizer: The 31^<st> Annual ISGP Meeting
  • Place of Presentation: Trieste, Italy
• [Presentation] Some aspects of HSF1-related stress response in the plasticity of mammalian skeletal muscle (2010)
  • Author(s): Goto, K., Y. Ohno, A. Nakai, T. Sugiura, Y. Ohira, and T. Yoshioka
  • Organizer: FASEB Summer Research Conferences 2010" Skeletal Muscle Satellite & Stem Cells"
• [Book] 運動・加齢に対する骨格筋の適応, The Bone 24 (2010)
  • Author(s): 上勝也、大平充宣