| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
In management of obesity-related liver diseases, that is, non-alcoholic fatty liver diseases, it is important to increase a utilization of glucose in the skeletal muscles and thereby to improve the insulin-resistance. Therefore, in subjects with non-alcoholic fatty liver diseases, it is also important to maintain the volume of skeletal muscles by appropriate exercise. In the assessment of effects of exercise on liver pathophysiology of non-alcoholic fatty liver diseases, we need to explore novel biomarkers that can reflect the status of liver pathophysiology in terms of steatosis, inflammation, and fibrosis, and to develop a non-invasive measurement system of these biomarkers. In this research project, using the serum samples of middle-aged obese men who joined a weight-losing course, we explored novel biomarkers that can scale the improvement of liver pathophysiology induced by exercise. We measured an enzyme activity of N-acetylglucosaminyltransferase V (GnT-V) in the serum samples as a glyco-biomaker. Exercise increased the energy consumption, maintained the lean body mass, and decreased the serum levels of ferritin and TBARS, an oxidative stress marker, in comparison with diet restriction. Taken together, it is likely that serum levels of ferritin and TBARS are useful biomarkers to scale the effects of exercise on liver pathophysiology in obese men. Exploration of novel glycol-biomarkers is being performed.
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