Expressional and regulatory characterization of mRNA and miRNA for food-intake related molecules

• Project/Area Number: 22650179
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Nara Women's University
• Principal Investigator: MATSUDA Satoru 奈良女子大学, 研究院生活環境科学系, 教授 (50242110)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 健康と食生活 / 遺伝子発現 / 細胞内シグナル伝達 / 摂食ホルモン / 食健康 / 遺伝子 / 発現制御 / 生理活性 / 食品成分 / 食品

Research Abstract

Some of herbs and spices have shown potential in preventing the occurrence and/or progression of cancer and other chronic diseases including anorexia. They are being screened to explore the possibility of development of feasible medical drugs by analyzing the expression of mRNA and miRNA. For example, mRNA and protein expression levels of AKT1 were reduced compared with the control cells 48 hours after these herbal treatments in cells treated with sage or rosemary extract.

Research Products

• [Journal Article] Expression and Function of PPARs in Placenta. (2013)
  • Author(s): S. Matsuda, M. Kobayashi, Y. Kitagishi
  • Journal Title: PPAR Res Volume: 2013 Pages: 256508-256508
• [Journal Article] Function and characteristics of PINK1 in mitochondria. (2013)
  • Author(s): S. Matsuda, Y. Kitagishi, M. Kobayashi
  • Journal Title: Oxid Med Cell Longev Volume: 2013 Pages: 601587-601587
• [Journal Article] Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease. (2013)
  • Author(s): Matsuda S
  • Journal Title: ISRN Endocrinol. Volume: 2013 Pages: 472432-472432
  • DOI: 10.1155/2013/472432
  • Peer Reviewed
• [Journal Article] Expression and Function of PPARs in Placenta. (2013)
  • Author(s): Matsuda S
  • Journal Title: PPAR Res. Volume: 2013 Pages: 256508-256508
  • DOI: 10.1155/2013/256508
  • Peer Reviewed
• [Journal Article] Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses. (2012)
  • Author(s): Y. Kitagishi, M. Kobayashi, K. Kikuta, S. Matsuda
  • Journal Title: Depress Res Treat Volume: 2012 Pages: 752563-752563
• [Journal Article] Defective DNA repair systems and the development of breast and prostate cancer. (2012)
  • Author(s): Y. Kitagishi, M. Kobayashi, S. Matsuda
  • Journal Title: Int J Oncol Volume: 42(1) Pages: 29-34
• [Journal Article] Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells. (2012)
  • Author(s): N. Okumura, H. Yoshida, Y. Nishimura, Y. Kitagishi, S. Matsuda
  • Journal Title: Oncol Lett Volume: 3(2) Pages: 321-324
• [Journal Article] PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis. (2012)
  • Author(s): Okumura N
  • Journal Title: Adv Hematol. Volume: 2012 Pages: 843085-843085
  • DOI: 10.1155/2012/843085
  • Peer Reviewed
• [Journal Article] Elucidating the regulation of T cell subsets (2012)
  • Author(s): Kitagishi Y, 他
  • Journal Title: Int J Mol Med Volume: 30 Issue: 6 Pages: 1255-1260
  • DOI: 10.3892/ijmm.2012.1152
  • Peer Reviewed
• [Journal Article] Protection against Cancer with Medicinal Herbs via Activation of Tumor Suppressor (2012)
  • Author(s): Kitagishi Y, 他
  • Journal Title: J Oncol Volume: 2012 Pages: 236530-236530
  • DOI: 10.1155/2012/236530
  • Peer Reviewed
• [Journal Article] Genistein downregulates presenilin 1 and ubiquilin 1 expression (2012)
  • Author(s): Matsuda S, Okumura N, et al
  • Journal Title: Mol Med Report Volume: 5 Pages: 559-561
  • DOI: 10.3892/mmr.2011.648
  • Peer Reviewed
• [Journal Article] Peppermint up-regulated JMJD1B protein expression in Daudi culture cells. (2011)
  • Author(s): Y. Kitagishi, Y. Nishimura, H. Yoshida, N. Okumura, M. Murakami, S. Matsuda
  • Journal Title: Int. J.Curr. Res Volume: 3 Pages: 365-368
• [Journal Article] Turmeric and curcumin repressed presenilin1 protein expression in Jurkat cells. (2011)
  • Author(s): H. Yoshida, N. Okumura, Y. Kitagishi, Y. Nishimura, S. Matsuda
  • Journal Title: Experimental and Therapeutic Medicine Volume: 2 Pages: 629-632
• [Journal Article] Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells. (2011)
  • Author(s): Y. Nishimura, Y. Kitagishi, H. Yoshida, N. Okumura, S. Matsuda
  • Journal Title: Molecular Medicine Reports Volume: 4 Pages: 727-730
• [Journal Article] Ethanol extract of Rosemary repressed PTEN expression in K562 culture cells. (2011)
  • Author(s): H. Yoshida, N. Okumura, Y. Kitagishi, Y. Nishimura, S. Matsuda
  • Journal Title: Int J appl Boil pharm Technol Volume: 2 Pages: 316-322
• [Journal Article] Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer (2011)
  • Author(s): Matsuda S, Okumura N, et al
  • Journal Title: Biochem Biophys Res Commun Volume: 413 Pages: 395-399
  • Peer Reviewed
• [Journal Article] How do you RUN on? (2011)
  • Author(s): Matsuda S, Yoshida H, et al
  • Journal Title: FEBS Lett Volume: 585 Pages: 1707-1710
  • Peer Reviewed
• [Journal Article] Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells (2011)
  • Author(s): Matsuda S, Nishimura Y, et al
  • Journal Title: Mol Med Report Volume: 4 Pages: 727-730
  • DOI: 10.3892/mmr.2011.487
  • Peer Reviewed
• [Journal Article] Turmeric and curcumin repressed presenilin1 protein expression in Jurkat cells. (2011)
  • Author(s): Matsuda S, Yoshida H, et al.
  • Journal Title: Experimental and Therapeutic Medicine Volume: (In press)
  • Peer Reviewed
• [Journal Article] Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells. (2011)
  • Author(s): Matsuda S, Nishimura Y, et al.
  • Journal Title: Molecular Medicine Reports Volume: (In press)
  • Peer Reviewed
• [Journal Article] Ethanol extract of Rosemary repressed PTEN expression in K562 culture cells. (2011)
  • Author(s): Matsuda S, Yoshida H, et al.
  • Journal Title: Int J appl Biol pharm Technol Volume: 2 Pages: 316-322
  • Peer Reviewed
• [Presentation] 食品成分刺激による細胞内リン酸化蛋白質の変化 (2013)
  • Author(s): 北岸靖子、松田覚
  • Organizer: 日本家政学会第65回大会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-18
• [Presentation] 香辛料による老化遺伝子発言調節の解析 (2011)
  • Author(s): 西村友里、吉田仁美、奥村奈央子、北岸靖子、立石知佳、松田覚
  • Organizer: 日本家政学会第63回大会
  • Place of Presentation: 千葉
  • Year and Date: 2011-05-28
• [Presentation] 食品成分を用いた毒性の低い遺伝子導入試薬開発の試み (2010)
  • Author(s): 北岸靖子、吉田仁美、松田覚
  • Organizer: 日本家政学会第62回大会
  • Place of Presentation: 広島
  • Year and Date: 2010-05-29
• [Presentation] 香辛料刺激による摂食ホルモン遺伝子発現調節の検討 (2010)
  • Author(s): 吉田仁美、北岸靖子、西村友里、松田覚
  • Organizer: 日本家政学会第62回大会
  • Place of Presentation: 広島
  • Year and Date: 2010-05-29