Significant roles of G protein-coupled receptors in anti-metabolic syndrome activities of dietary fibers

• Project/Area Number: 22650183
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Osaka City University
• Principal Investigator: SAEKI Shigeru 大阪市立大学, 大学院・生活科学研究科, 教授 (60211926)
• Co-Investigator(Kenkyū-buntansha): FUKUMURA Tomoe 大阪市立大学, 大学院・生活科学研究科, 講師 (80336792)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 食物繊維 / 短鎖脂肪酸 / GPCR

Research Abstract

It has been reported that short-chain fatty acids which are ligands of an orphan G protein-coupled receptor GPR41 stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. We speculated that s