| Project/Area Number |
22650224
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Carcinogenesis
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| Research Institution | Osaka City University |
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Principal Investigator |
KAWADA Norifumi 大阪市立大学, 大学院・医学研究科, 教授 (30271191)
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| Co-Investigator(Kenkyū-buntansha) |
LE Thuy 大阪市立大学, 大学院・医学研究科, 博士研究員 (10572175)
OGAWA Tomohiro 大阪市立大学, 大学院・医学研究科, 博士研究員 (70448752)
MOTOYAMA Hiroyuki 大阪市立大学, 大学院・医学研究科, 医員 (00573601)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,330,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | サイトグロビン / ビタミンA / 乳癌 / 線維芽細胞 / 自然発症 / 間質細胞 |
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| Research Abstract |
Incidence of breast cancer has been increasing in developed countries including Japan and has become a world-wide health problem. To clarify the molecular function of cytoglobin(Cygb) in vivo, we generated Cygb-deficient mice. Surprisingly, we observed the spontaneous development of breast cancer and lymphoma in Cygb-deficient female mice at high incidence compared to the negligible detection of such tumors in wild-type mice. Based on these findings, we studied the molecular events leading to breast cancer development in Cygb-deficiency with special regards to the interaction between epithelial cells and mesenchymal cells.
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