| Project/Area Number |
22650231
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor immunology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ITO Masaki 東京慈恵会医科大学, 医学部, 助教 (80297366)
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| Co-Investigator(Kenkyū-buntansha) |
HOMMA Sadamu 東京慈恵会医科大学, 医学部, 准教授 (50192323)
KOIDO Shigeo 東京慈恵会医科大学, 医学部, 准教授 (70266617)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBA Kiyotaka がん研究所, 蛋白創製研究部, 部長 (40196415)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 人工タンパク質 / MolCraft / 細胞性免疫 / OVA / 樹状細胞 / 腫瘍免疫 / 液性免疫 / がん / 腫瘍免疫療法 / 人工蛋白質 / 免疫 / WT1 |
|---|
| Research Abstract |
We have constructed an artificial protein library by combinatorially assembling four peptide motifs associated with the MHC class I epitope and MHC class II epitope of OVA(Ovalbumin), alpha-helical motif and randomized peptide sequence, respectively. We have generated two artificial proteins, F37A and F182A, which have the ability to induce OVA-specific cellular immunity without using any adjuvant. These exogenous proteins presented OVA-specific MHC class I epitope through the cross-presentation pathway in the antigen presenting cells. Our studies have demonstrated that the motif-programmed artificial proteins might be able to induce cellular immunity contribute to cancer immunotherapy.
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