| Project/Area Number |
22650232
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor immunology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
HOMMA Sadamu 東京慈恵会医科大学, 医学部, 准教授 (50192323)
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| Co-Investigator(Kenkyū-buntansha) |
KOIDO Shigeo 東京慈恵会医科大学, 医学部, 准教授 (70266617)
ITO Masaki 東京慈恵会医科大学, 医学部, 助教 (80297366)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | iPS細胞 / 血管前駆細胞 / 腫瘍血管 / 血管新生 / 樹状細胞 / 血管内皮細胞 / 血管周細胞 / 抗腫瘍効果 / がんワクチン / 癌免疫療法 |
|---|
| Research Abstract |
Induced Pluripotent Stem(iPS) cells are able to differentiate into vascular progenitor cells(iVP cells). Immunization of mice with dendritic cells pulsed with iVP cell lysate could induce potent antitumor immunity. Development of tumor vascular system was significantly suppressed and antibody against vascular endothelial cells was induced in the immunized mice. It is suggested that immunization with iVP cells could confer antitumor activity by induction of immune response against tumor vasculature.
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