Immunotherapy targeting tumor vascular cells using iPS cell-derived vaccine
| Project/Area Number |
22650232
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Tumor immunology
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
HOMMA Sadamu 東京慈恵会医科大学, 医学部, 准教授 (50192323)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOIDO Shigeo 東京慈恵会医科大学, 医学部, 准教授 (70266617)
ITO Masaki 東京慈恵会医科大学, 医学部, 助教 (80297366)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | iPS細胞 / 血管前駆細胞 / 腫瘍血管 / 血管新生 / 樹状細胞 / 血管内皮細胞 / 血管周細胞 / 抗腫瘍効果 / がんワクチン / 癌免疫療法 |
|---|
| Research Abstract |
Induced Pluripotent Stem(iPS) cells are able to differentiate into vascular progenitor cells(iVP cells). Immunization of mice with dendritic cells pulsed with iVP cell lysate could induce potent antitumor immunity. Development of tumor vascular system was significantly suppressed and antibody against vascular endothelial cells was induced in the immunized mice. It is suggested that immunization with iVP cells could confer antitumor activity by induction of immune response against tumor vasculature.
|
Report
(3 results)
Research Products
(34 results)
-
-
-
[Journal Article] Current immunotherapeutic approaches in pancreatic cancer2011
Author(s)
Koido S, Homma S, Takahara A, Namiki Y, Tsukinaga S, Mitobe J, Odahara S, Yukawa T, Matsudaira H, Nagatsuma K, Uchiyama K, Satoh K, Ito M, Komita H, Arakawa H, Ohkusa T, Gong J, Tajiri H
-
Journal Title
Clin Dev Immunol
Volume: 2011
Pages: 267539-267539
Related Report
Peer Reviewed
-
[Journal Article] Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response2011
Author(s)
Takahara A, Koido S, Ito M, Nagasaki E, Sagawa Y, Iwamoto T, Komita H, Ochi T, Fujiwara H, Yasukawa M, Mineno J, Shiku H, Nishida S, Sugiyama H, Tajiri H, Homma S
-
Journal Title
Cancer Immunol Immunother
Volume: 60(9)
Pages: 1289-1297
Related Report
Peer Reviewed
-
[Journal Article] Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines2011
Author(s)
Koido S, Homma S, Takahara A, Namiki Y, Komita H, Nagasaki E, Ito M, Nagatsuma K, Uchiyama K, Satoh K, Ohkusa T, Gong J, Tajiri H
-
Journal Title
J Biomed Biotechnol
Volume: 2011
Pages: 910836-910836
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions2010
Author(s)
Koido S, Homma S, Hara E, Namiki Y, Takahara A, Komita H, Nagasaki E, Ito M, Ohkusa T, Gong J, and Tajiri H
-
Journal Title
Clin Dev Immunol
Volume: Volume 2010
Pages: 14-14
Related Report
Peer Reviewed
-
[Journal Article] Dendritic/pancreatic carcinoma fusions for clinical use : comparative functional analysis of healthy-versus patient-derived fusions2010
Author(s)
Koido S, Hara E, Homma S, Namiki Y, Komita H, Takahara A, Nagasaki E, Ito M, Sagawa Y, Mitsunaga M, Uchiyama K, Satoh K, Arihiro S, Ohkusa T, Gong J, Tajiri H
-
Journal Title
Clin Immunol
Volume: 135
Pages: 384-400
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
