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Development of a novel method for discovering fusion genes causative for tumorigenesis

Research Project

Project/Area Number 22650234
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Tumor diagnosis
Research InstitutionKurume University

Principal Investigator

MIZUNO Shinichi  久留米大学, 医学部, 講師 (40569430)

Co-Investigator(Renkei-kenkyūsha) OKU Eijiro  久留米大学, 医学部, 助教 (10569429)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,530,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords発現解析 / ゲノム / 癌 / バイオテクノロジー
Research Abstract

We developed a novel tool of gene analysis, based on a mate-pair analysis, to discover fusion genes that could be causative for tumorigenesis. In conventional mate-pair analysis, there must contain circularized DNAs derived from multiple DNAs and their mate-pair fragments can be a cause of false positive fusion genes. To solve this problem we developed a novel method which allows us to prepare circularized DNA libraries in which each circularized DNA is originated from each single DNA. By this method, we can make a systematic survey of the presence of fusion genes in cancers in a highly precise manner.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Presentation (3 results) Patent(Industrial Property Rights) (4 results)

  • [Presentation] 新しい遺伝子検査法-がん融合遺伝子の新規探索法-2012

    • Author(s)
      水野晋一
    • Organizer
      BIO tech 2012
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 新しい遺伝子検査法-がん融合遺伝子の新規探索法-2011

    • Author(s)
      水野晋一
    • Organizer
      Bio Japan 2011
    • Place of Presentation
      横浜
    • Year and Date
      2011-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 新しい遺伝子検査法-がん融合遺伝子の新規探索法-2011

    • Author(s)
      水野晋一
    • Organizer
      BioJapan 2011
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] DNA分子の環状化において単分子による環状化DNAのみを選別する方法2011

    • Inventor(s)
      水野晋一、小澤秀俊、長藤宏司、岡村孝
    • Industrial Property Rights Holder
      久留米大学
    • Filing Date
      2011-08-31
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] DNA分子の環状化において単分子による環状化DNAのみを選別する方法2011

    • Inventor(s)
      水野晋一、小澤秀俊、長藤宏司、岡村孝
    • Industrial Property Rights Holder
      久留米大学
    • Industrial Property Number
      2011-189280
    • Filing Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 単分子DNAから形成される環状DNAの作成方法2010

    • Inventor(s)
      水野晋一、長藤宏治、岡村孝
    • Industrial Property Rights Holder
      久留米大学
    • Filing Date
      2010-09-02
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 単分子DNAから形成される環状DNAの作成方法2010

    • Inventor(s)
      水野晋一、長藤宏司、岡村孝
    • Industrial Property Rights Holder
      久留米大学
    • Industrial Property Number
      2010-196719
    • Filing Date
      2010-09-02
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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