| Project/Area Number |
22650235
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KITANAKA Chifumi 山形大学, 医学部, 教授 (70260320)
TOMIYAMA Arata 山形大学, 医学部, 助教 (40385810)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,350,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 抗がん物質探索 / ケミカルバイオロジー / がん / 化学療法 / 治療耐性 |
|---|
| Research Abstract |
In this study, we aimed at overcoming the therapeutic resistance of intractable cancersthrough activation of mitochondrial respiration. In the course of the study, we identified achemical agent capable of promoting mitochondrial respiration of glioma cells and alsoconfirmed that the chemical agent overcomes temozolomide resistance of glioma cells invitro. In vivo, the chemical agent synergized with temozolomide to inhibit tumor growth inthe subcutaneous xenograft model. However, the synergistic anti-tumor effect of thesedrugs remains to be demonstrated in the intracranial xenograft model.
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