Creation of the anti-neoplasmic acrylate-nanopolymer with amino acid
| Project/Area Number |
22650237
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 抗ガン物質探索 / ケミカルバイオロジー |
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| Research Abstract |
New nanopolymers with amino acid were newly synthesized by using essential amino acids and n-butylcyanoacrylate medicine.
This nano particle showed antitumor effects dependent on time and concentration to the lymphatic tumor cell and epithelium tumor cell strains. The antineoplasmic effect Such nano-particles, showd strong effect, were those coupled with Gly, Asp, Asn, and His.
This nano particle activated caspases 8 and caspases 3 were activated, then the apoptosis's cell death is induced subsequently by DNA cleavage. In vivo, this nano particle inhibited notably tumorigenesis by transplantation to a nude mice.
This nano polymer coupled with amino acid is hopeful as a new treatment of cancers also cancer prevention.
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Report
(3 results)
Research Products
(19 results)
