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Self-assembly of DNA-functionalized hydrogel microstructure

Research Project

Project/Area Number 22651049
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Microdevices/Nanodevices
Research InstitutionThe University of Tokyo

Principal Investigator

ONOE Hiroaki  東京大学, 生産技術研究所, 助教 (30548681)

Co-Investigator(Kenkyū-buntansha) TAKINOUE Masahiro  東京工業大学, 大学院・総合理工学研究科, 講師 (20511249)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,440,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsマイクロナノデバイス / Self-assembly / DNA / ハイドロゲル / ソフトマテリアル / ヤヌス粒子 / 遠心力 / ナノマシン / ゲルビーズ / 遠心器
Research Abstract

We developed a simple synthesis method of hydrogel micro-structures under ultra-high gravity created by a centrifuge. Using this method, we achieved(1) keepingthe surface of hydrogel micro-structures that can be directly modified with functional molecules,(2) creating anisotropic and multi-compartmentalized hydrogelmicro-structures by using multi-barreled capillary,(3) functionalizing the hydrogelmicro-structures by encapsulating both magnetic nanobeads and living cellsat thesame time, and(4) self-assembling the magnetic-active hydrogel micro-structuresby applying an external magnetic field.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Controlled synthesis of 3D multi-compartmental particles with centrifuge-based microdroplet formation from a multi-barrelled capillary2012

    • Author(s)
      Kazuki Maeda, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Journal Title

      Advanced Materials

      Volume: 24 Issue: 10 Pages: 1340-1346

    • DOI

      10.1002/adma.201102560

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] DNAナノカプセル構築へ応用可能な遠心マイクロゲルビーズ作製法の開発2011

    • Author(s)
      前田一輝,尾上弘晃,瀧ノ上正浩,竹内昌治
    • Organizer
      計測自動制御学会システム・情報部門学術講演会
    • Place of Presentation
      国立オリンピックセンター
    • Year and Date
      2011-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] DNAナノカプセル構築へ応用可能な遠心マイクロゲルビーズ作製法の開発2011

    • Author(s)
      前田一輝, 尾上弘晃, 瀧ノ上正浩, 竹内昌治
    • Organizer
      計測自動制御学会システム・情報部門学術講演会(SSI2011)
    • Place of Presentation
      国立オリンピックセンター
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Centrifuge-Based Droplet Shooting Device for the Synthesis of Multi-Compartmental Microspheres under Ultra-High Gravity, Fifteenth International Conference on Miniturized Systems for Chemistry and Life Science(microTAS)2011

    • Author(s)
      Kazuki Maeda, Masahiro Takinoue
    • Organizer
      Seatle
    • Place of Presentation
      USA
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] A Centrifuge-Based Droplet Shooting Device for the Synthesis of Multi-Compartmental Microspheres under Ultra-High Gravity2011

    • Author(s)
      Kazuki Maeda, Masahiro Takinoue, Hiroaki Onoe, Shoji Takeuchi
    • Organizer
      Fifteenth International Conference on Miniturized Systems for Chemistry and Life Science (microTAS)
    • Place of Presentation
      Seatle, USA
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遠心機を用いたマイクロゲルビーズ生成法2011

    • Author(s)
      前田一輝,尾上弘晃,瀧ノ上正浩,竹内昌治
    • Organizer
      バイオ・マイクロシステム研究会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] DNAマイクロカプセルのためのマイクロゲルビーズ作製法の開発2011

    • Author(s)
      前田一輝,尾上弘晃,瀧ノ上正浩,竹内昌治
    • Organizer
      分子ロボティクス研究会
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 遠心機を利用した一細胞封入ゲルの作製2011

    • Author(s)
      稲森貴一,尾上弘晃,瀧ノ上正浩,竹内昌治
    • Organizer
      第11回東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 遠心器を利用した-細胞封入ゲルの作成2011

    • Author(s)
      稲森貴一, 尾上弘晃, 瀧ノ上正浩, 竹内昌治
    • Organizer
      第11回東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 液体ゲル化装置及び液体ゲル化方法2011

    • Inventor(s)
      竹内昌治、尾上弘晃、瀧ノ上正浩、稲森貴一、前田一輝
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2011-041487
    • Filing Date
      2011-02-28
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 液体ケル化装置及び液体ケル化方法2011

    • Inventor(s)
      竹内昌治、尾上弘晃、瀧ノ上正浩、稲森貴一、前田一輝
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2011-041487
    • Filing Date
      2011-02-28
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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