Healthful regulation of body fat percentage by somatolactin

• Project/Area Number: 22651074
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Medical genome science
• Research Institution: Japan Women's University
• Principal Investigator: FUKAMACHI Shoji 日本女子大学, 理学部, 准教授 (20323446)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,430,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: メダカ / ソマトラクチン / 脂肪率

Research Abstract

It has been indicated that somatolactin(SLa) would function to regulate triglycerides in the muscles and liver. The purpose of this study is to verify the function and explore a possibility for its application to fisheries. Using the mutant and transgenic strains of the SLa gene which were bred under various breeding conditions, we found that the internal/external environments(age and foods) have more effects on percent hepatic triglycerides than the SLa expression.

Research Products

• [Journal Article] ヒメダカ体色原因遺伝子マーカーによる奈良県大和川水系のメダカ集団の解析 (2011)
  • Author(s): 中井宏施、中尾遼平、深町昌司、小山直人、北川忠生
  • Journal Title: 魚類学雑誌 Volume: 58巻2号 Pages: 189-194
  • NAID: 130003397815
  • Peer Reviewed
• [Journal Article] Reassessment of the function of somatolactin alpha in lipid metabolism using medaka mutant and transgenic strains
  • Author(s): Y.Sasano, A.Yoshimura, S.Fukamachi
  • Journal Title: BMC Genetics Volume: (投稿中)
  • Peer Reviewed
• [Presentation] メダカにおける成長ホルモン受容体(GHR)とソマトラクチン受容体(SLR)の機能分化 (2011)
  • Author(s): 小峰律子、木村哲晃、成瀬清、深町昌司
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 北海道旭川市
  • Year and Date: 2011-09-21
• [Presentation] ヒメダカの目が黒い理由(わけ) (2010)
  • Author(s): 深町昌司
  • Organizer: 第23回日本色素細胞学会学術大会
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 2010-11-28