Instability of chromatin structure caused by inter-subspecies mouse hybrids

• Project/Area Number: 22651075
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Medical genome science
• Research Institution: Fujita Health University (2011-2012); 大学共同利用機関法人情報・システム研究機構(新領域融合研究センター、DBCLS) (2010)
• Principal Investigator: UMEMORI Juzoh 藤田保健衛生大学, 総合医科学研究所, 助教 (20462913)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,790,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
• Keywords: 遺伝的不適合 / 髄鞘形成不全 / レトロトランスポゾン / 低分子 RNA / エピジェネティクス / 低分子RNA / 遺伝子不適合

Research Abstract

Genetically incompatible mice, which are generated by inter-subspecies breeding, showpleiotropic defects, including lethality and dysmyelination in the spinal cord. Theyalso exhibit epigenetic abnormalities in the central nervous system, such asdysregulation of an LTR-type retrotransposon, IAP (Intracisternal A-particle), anddemethylation in the genomic region. The present study revealed that expression patternof various kinds of small RNA are dramatically changed in the neonatal spinal cordin mice, suggesting that genetic incompatibility results in genome-wide alterationsof epigenetic states and instability of chromatin structure.

Research Products

• [Journal Article] ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. (2013)
  • Author(s): Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T.
  • Journal Title: BMC Res Notes Volume: 6(1) Pages: 203-203
  • Peer Reviewed
• [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. (2013)
  • Author(s): Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
  • Journal Title: Neuropsychopharmacology Volume: 38(8) Issue: 8 Pages: 1409-25
  • DOI: 10.1038/npp.2013.38
  • Peer Reviewed / Open Access
• [Presentation] Behavioral state of model mice of bipolar disorders can be retrospectively predicted by gene expression and metabolome patterns (2012)
  • Author(s): Umemori J, Hagihara H, Nakamura KH, Horikawa T, Shoji H, Toyama K, Irino Y, Yoshida M, Kamitani Y, Miyakawa T
  • Organizer: Society for Neuroscience 2012
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2012-10-15
• [Presentation] Behavioral stateof model mice of bipolar disorders can beretrospectively predicted by gene expression and metabolome patterns (2012)
  • Author(s): Umemori J, Hagihara H, Nakamura KH, HorikawaT, Shoji H, Toyama K, Irino Y, Yoshida M,Kamitani Y, Miyakawa T
  • Organizer: The35th Annual Meeting of Society forNeuroscience
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2012-09-18
• [Presentation] Neurological defects caused by geneticincompatibility in mice (2011)
  • Author(s): Umemori J, Mori A, Uno T, Yuasa S, Koide T
  • Organizer: Society forNeuroscience 2011
  • Place of Presentation: Washington,DC
  • Year and Date: 2011-11-16
• [Presentation] Neurological defects caused by genetic incompatibility in mice (2011)
  • Author(s): J.UMEMORI, A.MORI, T.UNO, S.YUASA, T.KOIDE
  • Organizer: Society for Neuroscience 2011
  • Place of Presentation: Washington DC, US
  • Year and Date: 2011-11-16
• [Presentation] Dysmyelination and tremor caused bygenetic incompatibility in mice (2010)
  • Author(s): Umemori J, Mori A, Uno T, Yuasa S, Koide T
  • Organizer: Societyfor Neuroscience 2010
  • Place of Presentation: SanDiego, CA
  • Year and Date: 2010-11-14
• [Presentation] Dysmyelination and tremor caused by genetic incompatibility in mice (2010)
  • Author(s): J.UMEMORI, et al.
  • Organizer: Neuroscience2010
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-14
• [Presentation] 遺伝的不適合マウスにおけるエピジェネティック異常 (2010)
  • Author(s): 梅森十三
  • Organizer: 第82回日本遺伝学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-20
• [Presentation] Epigenetic abnormality of genetic incompatibility mouse, Gepic mice (2010)
  • Author(s): 梅森十三, et al.
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Book] マウス胚発生カレンダー (2010)
  • Author(s): 梅森十三、小久保博樹、小出剛、相賀裕美子
  • Publisher: Medical Bio