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Instability of chromatin structure caused by inter-subspecies mouse hybrids

Research Project

Project/Area Number 22651075
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical genome science
Research InstitutionFujita Health University (2011-2012)
大学共同利用機関法人情報・システム研究機構(新領域融合研究センター、DBCLS) (2010)

Principal Investigator

UMEMORI Juzoh  藤田保健衛生大学, 総合医科学研究所, 助教 (20462913)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,790,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
Keywords遺伝的不適合 / 髄鞘形成不全 / レトロトランスポゾン / 低分子 RNA / エピジェネティクス / 低分子RNA / 遺伝子不適合
Research Abstract

Genetically incompatible mice, which are generated by inter-subspecies breeding, showpleiotropic defects, including lethality and dysmyelination in the spinal cord. Theyalso exhibit epigenetic abnormalities in the central nervous system, such asdysregulation of an LTR-type retrotransposon, IAP (Intracisternal A-particle), anddemethylation in the genomic region. The present study revealed that expression patternof various kinds of small RNA are dramatically changed in the neonatal spinal cordin mice, suggesting that genetic incompatibility results in genome-wide alterationsof epigenetic states and instability of chromatin structure.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2013 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (8 results) Book (1 results)

  • [Journal Article] ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response.2013

    • Author(s)
      Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T.
    • Journal Title

      BMC Res Notes

      Volume: 6(1) Pages: 203-203

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013

    • Author(s)
      Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38(8) Issue: 8 Pages: 1409-25

    • DOI

      10.1038/npp.2013.38

    • Related Report
      2012 Final Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Behavioral state of model mice of bipolar disorders can be retrospectively predicted by gene expression and metabolome patterns2012

    • Author(s)
      Umemori J, Hagihara H, Nakamura KH, Horikawa T, Shoji H, Toyama K, Irino Y, Yoshida M, Kamitani Y, Miyakawa T
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2012-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Behavioral stateof model mice of bipolar disorders can beretrospectively predicted by gene expression and metabolome patterns2012

    • Author(s)
      Umemori J, Hagihara H, Nakamura KH, HorikawaT, Shoji H, Toyama K, Irino Y, Yoshida M,Kamitani Y, Miyakawa T
    • Organizer
      The35th Annual Meeting of Society forNeuroscience
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurological defects caused by geneticincompatibility in mice2011

    • Author(s)
      Umemori J, Mori A, Uno T, Yuasa S, Koide T
    • Organizer
      Society forNeuroscience 2011
    • Place of Presentation
      Washington,DC
    • Year and Date
      2011-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurological defects caused by genetic incompatibility in mice2011

    • Author(s)
      J.UMEMORI, A.MORI, T.UNO, S.YUASA, T.KOIDE
    • Organizer
      Society for Neuroscience 2011
    • Place of Presentation
      Washington DC, US
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dysmyelination and tremor caused bygenetic incompatibility in mice2010

    • Author(s)
      Umemori J, Mori A, Uno T, Yuasa S, Koide T
    • Organizer
      Societyfor Neuroscience 2010
    • Place of Presentation
      SanDiego, CA
    • Year and Date
      2010-11-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Dysmyelination and tremor caused by genetic incompatibility in mice2010

    • Author(s)
      J.UMEMORI, et al.
    • Organizer
      Neuroscience2010
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝的不適合マウスにおけるエピジェネティック異常2010

    • Author(s)
      梅森十三
    • Organizer
      第82回日本遺伝学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-20
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Epigenetic abnormality of genetic incompatibility mouse, Gepic mice2010

    • Author(s)
      梅森十三, et al.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Book] マウス胚発生カレンダー2010

    • Author(s)
      梅森十三、小久保博樹、小出剛、相賀裕美子
    • Publisher
      Medical Bio
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2023-01-13  

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