Synthetic Strategy to Idiotype Molecules in or on Live Cells by Efficient Bond-Forming Reactions
| Project/Area Number |
22651081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research (2012)
Osaka University (2010-2011) |
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Principal Investigator |
TANAKA Katsunori 独立行政法人理化学研究所, 田中生体機能合成化学研究室, 准主任研究員 (00403098)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ペプチド / イディオタイプ / ダイナミック・コンビナトリアルケミストリー / シンセティックバイオロジー / 自己活性化型クリック反応 / Grb2-SH2ドメイン / 鋳型誘起反応 / 組織上 / 生体内 / 共役イミン / [4+4]反応 / ポリアミン / 糖鎖 / 6π-アザ電子環状反応 / SH2ドメイン |
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| Research Abstract |
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
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Report
(4 results)
Research Products
(109 results)
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[Journal Article] Template-Assisted and Self-Activating Clicked Peptide as a Synthetic Mimic of the SH2 Domain2012
Author(s)
Tanaka, K., Shirotsuki, S., Iwata, T., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E. R. O., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y., Fukase, K
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Journal Title
ACS Chem. Biol.
Volume: 7
Pages: 637-645
Related Report
Peer Reviewed
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[Journal Article] Auxiliary-directed oxidation of ursolic acid by 'Ru'-porphyrins: chemical modulation of cytotoxicity against tumor cell lines2012
Author(s)
Tanaka, K., Mazumder, K., Siwu, E. R. O., Nozaki, Satoshi, Watanabe, Y., Fukase, K.
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Journal Title
Tetrahedron Lett.
Volume: 53
Pages: 1756-1759
Related Report
Peer Reviewed
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[Journal Article] Efficient Synthesis of 2,6,9-Triazabicyclo[3.3.1]nonanes through Amine-Mediated Formal [4+4] Reaction of Unsaturated Imines2012
Author(s)
K. Tanaka, E. R. O. Siwu, S. Hirosaki, T. Iwata, R. Matsumoto, Y. Kitagawa, A. R. Pradipta, M. Okumura, K. Fukase
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Journal Title
Tetrahedron Lett.
Volume: 53
Pages: 5899-5902
Related Report
Peer Reviewed
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[Journal Article] Auxiliary-directed oxidation of ursolic acid by 'Ru'-porphyrins : chemical modulation of cytotoxicity against tumor cell lines2012
Author(s)
Tanaka, K., Mazumder, K., Siwu, E.R.O., Nozaki, Satoshi, Watanabe, Y., Fukase, K.
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Journal Title
Tetrahedron Lett.
Volume: 53
Issue: 14
Pages: 1756-1759
DOI
Related Report
Peer Reviewed
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[Journal Article] Template-assisted and self-activating clicked peptide as a synthetic mimic of SH2 domain2011
Author(s)
Tanaka, K., Shirotsuki, S., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E.R.O., Iwata, T., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y., Fukase, K
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Journal Title
ACS Chem.Biol.
Volume: (未定)(in press)
Issue: 4
Pages: 637-645
DOI
Related Report
Peer Reviewed
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[Presentation] Regulation of In Vivo Protein / Protein Interaction by Template-Assisted Synthesis2012
Author(s)
T. Iwata, K. Tanaka, S. Shirotsuki, C. Kageyama, T. Tahara, S. Nozaki, E. R. O. Siwu, S. Tamura, S. Douke, N. Murakami, H. Onoe, Y. Watanabe, K. Fukase
Organizer
The first International Symposium on Chemical Biology of Natural Products Target ID and Regulation of Bioactivity
Place of Presentation
京都
Related Report
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[Presentation] 鋳型誘起反応を用いたリン酸化タンパク質認識ペプチドの転写合成法の開発とその選択的な癌増殖抑制作用2012
Author(s)
田中克典, 岩田隆幸, 白坏早苗, 影山知佳, 田原強, 野崎聡, Eric R. O. Siwu, 田村 理, 道家駿佑, 村上啓寿, 尾上浩隆, 渡辺恭良, 深瀬浩一
Organizer
第54回天然物化学討論会
Place of Presentation
東京
Related Report
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