A combination study of chemical and systems biology identifying novelfeatures of signaling pathway in cancer cell migration
| Project/Area Number |
22651084
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
IMOTO Masaya 慶應義塾大学, 理工学部, 教授 (60213253)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ケミカルバイオロジー / 細胞遊走 / がん細胞 / システム生物学 / パスウェイ解析 / パスウエイ解析 / リポキシゲナーゼ |
|---|
| Research Abstract |
To analyze the diversity and consistency of regulatory signaling in cancer cell migration, the author assessed quantitatively the effects of 34 small molecular compounds on ten types of migrating cells by wound healing assay. Hierarchical clustering was p
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.2012
Author(s)
Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Comprehensive Predictions of Target Proteins Based on Protein-Chemical Interaction Using Virtual Screening and Experimental Verifications2012
Author(s)
Kobayashi H, Harada, H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura S, Shin-ya K, Doi T, Takahashi T, Natsume T, Imoto Mand Sakakibara Y
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Journal Title
BMC Chemical Biology
Volume: 12
Pages: 2-2
Related Report
Peer Reviewed
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[Journal Article] Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-172012
Author(s)
Kiga M, Tanzawa F, Iwasaki S, Inaba F, Fujiwara K, Iwadare H, Echigo T, Nakamura Y, Shibata T, Suzuki K, Yasumatsu, I Nakayama A, Sasazawa Y, Tashiro E, Imoto M, S. Kurakata S
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Journal Title
Anticancer Drugs
Volume: 23
Pages: 119-130
Related Report
Peer Reviewed
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[Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition2011
Author(s)
Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Kei-Ichi Ishikawa, Sato S, Imoto M, Hattori N
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Journal Title
Autophagy
Volume: 7
Pages: 42-53
Related Report
Peer Reviewed
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[Journal Article] Total Synthesis of Incednam, the Aglycon of Incednine.2010
Author(s)
T. Ohtani, S. Tsukamoto, H. Kanda, K. Misawa, Y. Urakawa, T. Fujimaki, M. Imoto,Y. Takahashi, D. Takahashi†, and K. Toshima
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Journal Title
Org. Lett.
Volume: 12
Pages: 5068-5071
Related Report
Peer Reviewed
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[Journal Article] Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomycessp. MK756-CF12010
Author(s)
Kawamura T, Fujimaki T, Hamanaka N, Torii K, Kobayashi H, Takahashi Y, Igarashi M, Kinoshita N, Nishimura Y, Tashiro E, Imoto M
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Journal Title
J. Antibiot.
Volume: 63
Pages: 601-605
Related Report
Peer Reviewed
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[Journal Article] Glyoxalase-I is a novel target against Bcr-Abl^+leukemic cells acquiring stem-like characteristics in hypoxic environment.2010
Author(s)
Takeuchi M, Kimura S, Kuroda J, Ashihara E, KawataniM, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T, Yokota A, Tanaka R, Nagao T, Nakahata N, Fujiyama Y Maekawa T
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Journal Title
Cell Death Diff
Volume: 17
Pages: 1211-1220
Related Report
Peer Reviewed
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