| Project/Area Number |
22655010
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
UCHIBE Kohei 筑波大学, 数理物質系, 准教授 (10348493)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | ジフルオロカルベン錯体 / フッ素化合物 / 触媒 / カルベン / フッ素 / ナザロフ環化 / ペンテノン / シクロプロパン / 白金 / カルベン錯体 / 触媒反応 / 有機合成反応 / ジフルオロシクロプロパン / ニッケル / 環拡大 |
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| Research Abstract |
Transition metal difluorocarbene complexes are promising active species for the synthesis of organofluorine compounds. We treated silyl enol ethers with trimethylsilyl 2,2-difluoro-2-fluorosulfonylacetate (TFDA) in the presence of pincer-type NHC nickel complex catalyst. By this reaction, cyclic silyl enol ethers bearing fluorine substituent were obtained in good yield. It is supposed that nickel difluorocarbene complex is generated in situ, and that sequential difluorocyclopropanation and ring expansion proceed to give the products.
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