Activation of Remote Carbon-Hydrogen Bond Based on the Creation of Functionalized Transition Metal Complexes
Project/Area Number |
22655013
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Organic chemistry
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
IWASAWA Nobuharu 東京工業大学, 大学院・理工学研究科, 教授 (40168563)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
Keywords | 合成有機化学 / 炭素-水素結合活性化 / 有機化学 / 合成化学 / ボリル化 / 炭素-水素結合活性化 / ボロン酸エステル / ホウ素化反応 / イリジウム錯体 / メタ位選択的ホウ素化 / 機能性錯体 / 遠隔位炭素-水素結合活性化 |
Research Abstract |
In this research, novel transition metal complexes bearing a substrate-binding moiety and a substrate-activating moiety on a rigid carbon backbone were designed to realize regioselective remote C-H bond activation. Thus, naphthalene derivatives which contain a bipyridine moiety for substrate-activation and a benzoindole moiety or a phenol moiety for substrate-binding were prepared and phenyl-substituted carboxylic acids or alcohols were introduced as substrate into the molecules. Borylation reaction was examined employing these substrates and only meta-borylated aromatic compounds were selectively produced. Thus these complexes recognize the specific C-H bond of substrates, which can not be realized by conventional methods.
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Report
(4 results)
Research Products
(4 results)