| Project/Area Number |
22655018
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Inorganic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Masaaki 九州大学, 大学院・工学研究院, 准教授 (90260033)
SHIMAKOSHI Hisashi 九州大学, 大学院・工学研究院, 助教 (00284539)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,490,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | 金属錯体化学 / 無機ヒ素 / メチル化反応 / ビタミンB_<12> / グルタチオン / チオール / コバルト錯体 / 有害化学物質 / ビタミンB12 / 触媒反応 / 金属錯体 / コバルト-メチル結合 / 環境技術 / ヒ素 |
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| Research Abstract |
Inorganic arsenic has caused serious chronic diseases throughenvironmental pollution. However, some methylated arsenic compounds, especiallytrimethylarsine oxide(TMAO) and arsenobatetaine(AB) have much lower toxicities thanarsenic trioxide(As2O3). The acute toxicity of AB, as determined from animal experiments, is approximately one three-hundredth of that of arsenic trioxide. Meanwhile, in marineecosystems, inorganic arsenicals are biologically methylated through the food chain, whichinvolves a methyltransferase and a reductase. An interesting application of the methyltransfer reaction with vitamin B_<12> to the detoxification system for inorganic arsenic hasbeen succeeded. This is a new and selective detoxification method for inorganic arsenic, which is the biomimetic methylation of arsenic trioxide(As2O3) to give trimethylarsineoxide(TMAO).
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