Improvement of production efficiency of iPS cells

• Project/Area Number: 22655052
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Chemistry related to living body
• Research Institution: Okayama University (2011); Kyoto University (2010)
• Principal Investigator: SERA Takashi 岡山大学, 大学院・自然科学研究科, 教授 (10362443)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: バイオテクノロジー / iPS細胞 / 遺伝子発現

Research Abstract

The goal of this study is to develop a new method to improve the production efficiency of iPS cells. We designed four molecules for the purpose. We generated and purified them. We identified the best molecule based on molecular biological properties. We furthermore improved the function of the molecule. Using it, we modulated the target function in cells.