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Analyses of Protein Folding Codon affecting protein functions

Research Project

Project/Area Number 22655057
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Chemistry related to living body
Research InstitutionKonan University

Principal Investigator

SUGIMOTO Naoki  甲南大学, フロンティアサイエンス学部, 教授 (60206430)

Co-Investigator(Kenkyū-buntansha) ENDOH Tamaki  甲南大学, 先端生命工学研究所, 講師 (90550236)
NAGATOISHI Satoru  甲南大学, 先端生命工学研究所, 助教 (30550248)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsProtein Folding Codon / 翻訳速度 / mRNA高次構造 / 熱力学的安定性 / タンパク質構造 / 分子クラウディング
Research Abstract

Synchronized translation, which enables time-course analyses of translation elongation, was constructed using in vitro translation system. The synchronized translation revealed that rare codons and stable RNA structures in open reading frame of mRNA temporarily stall the translation elongation. Contribution of protein binding to thermostability of particular nucleic acid structure was quantitatively evaluated under molecular crowding condition. Results from these analyses indicate that stabilities of mRNA structures possibly affect not only translation elongation process but also folding process of nascent proteins. In addition, correlation of thermostability of nascent mRNA structure and transcription efficiency was revealed by analyses of in vitro transcription.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (90 results)

All 2012 2011 2010 Other

All Journal Article (19 results) (of which Peer Reviewed: 14 results) Presentation (64 results) Book (5 results) Remarks (2 results)

  • [Journal Article] The yield of transcripts for RNA polymerase regulated by hairpin structures in nascent RNA2012

    • Author(s)
      S. Nagatoishi, R. Ono, and N. Sugimoto
    • Journal Title

      Chem. Commun.

      Volume: 48 Issue: 42 Pages: 5121-5123

    • DOI

      10.1039/c2cc31657a

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchronized Translation for Detection of Temporal Stalling of Ribosome during Single-Turnover Translation2012

    • Author(s)
      T. Endoh, Y. Kawasaki and N. Sugimoto
    • Journal Title

      Anal. Chem.

      Volume: 84 Issue: 2 Pages: 857-861

    • DOI

      10.1021/ac202712g

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG) : (CCCTAA) in nanocavity water pools of reverse micelles2012

    • Author(s)
      S.Pramanik, S.Nagatoishi, N.Sugimoto
    • Journal Title

      Chem.Commun.

      Volume: 48 Issue: 40 Pages: 4815-4817

    • DOI

      10.1039/c2cc30622k

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydration is Required in DNA G-Quadruplex-Protein Binding2011

    • Author(s)
      Nagatoishi S, Isono N, Tsumoto K, Sugimoto N
    • Journal Title

      Chembiochem.

      Volume: 12 Issue: 12 Pages: 1822-1826

    • DOI

      10.1002/cbic.201100264

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ポストゲノム時代の生命化学と次世代スパコン2011

    • Author(s)
      杉本直己
    • Journal Title

      化学

      Volume: 4 Pages: 31-33

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding2011

    • Author(s)
      S. Nagatoishi, N. Isono, K. Tsumoto, and N. Sugimoto
    • Journal Title

      Biochimie

      Volume: 93 Issue: 8 Pages: 1231-1238

    • DOI

      10.1016/j.biochi.2011.03.013

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational flexibility influences degree of hydration of nucleic acid hybrids2011

    • Author(s)
      S.Pramanik, S.Nagatoishi, S.Saxena, J.Bhattacharyya, N.Sugimoto
    • Journal Title

      J.Phys.Chem.B

      Volume: 115 Issue: 47 Pages: 13862-13872

    • DOI

      10.1021/jp207856p

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurements of the binding of a large protein using a substrate density-controlled DNA chip.2011

    • Author(s)
      S. Nakano, T. Kanzaki, M. Nakano, D. Miyoshi, and N. Sugimoto
    • Journal Title

      Anal. Chem.

      Volume: 83 Issue: 34 Pages: 6368-6372

    • DOI

      10.1021/bi200477g

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene regulation system with an artificial RNA switch operating in human cell2011

    • Author(s)
      T. Endoh and N. Sugimoto
    • Journal Title

      Chem Bio Chem

      Volume: 12 Issue: 8 Pages: 1174-1178

    • DOI

      10.1002/cbic.201100093

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurements of the binding of a large protein using a substrate density-controlled DNA chip2011

    • Author(s)
      S.Nakano, T.Kanzaki, M.Nakano, D.Miyoshi, N.Sugimoto
    • Journal Title

      Anal.Chem.

      Volume: 83 Issue: 16 Pages: 6368-6372

    • DOI

      10.1021/ac201312d

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA Morphologic Changes Induced by Sp ermine on a Gold Surface under DNA Crowding Conditions2011

    • Author(s)
      K.Kobayashi, H.Tateishi-Karimata, K.Tsutsui, Y.Wada, N.Sugimoto
    • Journal Title

      Chemistry Letters [Highlited as Editor's Choice]

      Volume: 40 Issue: 8 Pages: 855-857

    • DOI

      10.1246/cl.2011.855

    • NAID

      130004426294

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] G-quartet, G-quadruplex, and G-wire Regulated by Chemical Stimuli2011

    • Author(s)
      D.Miyoshi, N.Sugimoto
    • Journal Title

      DNA Nanotechnology (Methods in Molecular Biology series)

      Volume: 749 Pages: 93-104

    • DOI

      10.1007/978-1-61779-142-0_7

    • ISBN
      9781617791413, 9781617791420
    • Related Report
      2011 Annual Research Report
  • [Journal Article] グラフェンを用いたバイオセンサー2011

    • Author(s)
      三好大輔、杉本直己
    • Journal Title

      化学

      Volume: 66(8) Pages: 30-35

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 遺伝子制御を可能にするRNAの構造スイッチ2011

    • Author(s)
      遠藤玉樹、杉本直己
    • Journal Title

      ファルマシア

      Volume: 47 Pages: 146-150

    • NAID

      110009900900

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide.2011

    • Author(s)
      S.Pramanik, K.Nakamura, K.Usui, S.Nakano, S.Saxena, J.Matsui, D.Miyoshi, N.Sugimoto.
    • Journal Title

      Chem.Commun.

      Volume: 47 Pages: 2790-2792

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タンパク質の合成を制御する環境-分子クラウディングによる時間概念2010

    • Author(s)
      杉本直己、遠藤玉樹
    • Journal Title

      現代化学

      Volume: 472 Pages: 26-31

    • Related Report
      2011 Final Research Report
  • [Journal Article] Monomorphic RNA G-quadruplex and polymorphic DNA G-quadruplex structures responding to cellular environmental factors2010

    • Author(s)
      D.H.Zhang, T.Fujimoto, S.Saxena, H.Q.Yu, D.Miyoshi, N.Sugimoto
    • Journal Title

      Biochemisry

      Volume: 49 Pages: 4554-4563

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of functional Nucleic Acids with chemical modifications2010

    • Author(s)
      M.Kuwahara, N.Sugimoto
    • Journal Title

      Molecules

      Volume: 15 Pages: 5423-5444

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sole and stable RNA duplexes of G-rich sequences located in the 5'-untranslated region of protooncogenes2010

    • Author(s)
      S.Saxena, D.Miyoshi, N.Sugimoto
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 7190-7201

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 標的核酸や核酸医薬の構造と機能に及ぼす分子環境の影響2012

    • Author(s)
      杉本直己
    • Organizer
      第9回分子複合医薬研究会
    • Place of Presentation
      大阪
    • Year and Date
      2012-03-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 標的核酸や核酸医薬の構造と機能に及ぼす分子環境の影響2012

    • Author(s)
      杉本直己
    • Organizer
      第9回分子複合医薬研究会
    • Place of Presentation
      産業技術総合研究所・関西センター(大阪府)
    • Year and Date
      2012-03-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然mRNAの翻訳領域におけるRNA四重鎖の形成2012

    • Author(s)
      川崎悠・遠藤玉樹・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Related Report
      2011 Final Research Report
  • [Presentation] 天然mRNAの翻訳領域中に形成されるRNA四重鎖構造を介した翻訳伸長反応の抑制2012

    • Author(s)
      遠藤玉樹・川崎悠・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川
    • Related Report
      2011 Final Research Report
  • [Presentation] 特別講演会/脱ワトソン・クリック二重らせん-核酸の構造と機能に及ぼす分子環境効果2012

    • Author(s)
      杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然mRNAの翻訳領域におけるRNA四重鎖の形成2012

    • Author(s)
      川崎悠・遠藤玉樹・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然mRNAの翻訳領域中に形成されるRNA四重鎖構造を介した翻訳伸長反応の抑制2012

    • Author(s)
      遠藤玉樹・川崎悠・杉本直巳
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 鋳型DNA中の非標準構造形成による転写活性制御2012

    • Author(s)
      磯野伸・建石寿枝・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] RNase HとプローブRNAを用いたサイクリングプローブ技術によるPCRフリーのテロメラーゼ活性検出技術の開発2012

    • Author(s)
      夜久英信・村嶋貴之・三好大輔・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 逆ミセル中におけるテロメア配列DNAの四重鎖形成2012

    • Author(s)
      Pramanik Smritimoy・長門石暁・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Y-box結合タンパク質YB-1の核酸結合解析2012

    • Author(s)
      長門石暁・西方敬人・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分子クラウディング環境下におけるミスマッチ塩基対を含むRNA二重鎖の熱力学的安定性2012

    • Author(s)
      村上健太郎・建石寿枝・遠藤玉樹・中野修一・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水和イオン液体中におけるDNA構造安定性の定量的解析2012

    • Author(s)
      建石寿枝・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] RNAヘアピン構造の二量化反応の効率を決める要因の解明2012

    • Author(s)
      中野修一・平山英伸・山口大輔・三好大輔・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Behaviors of Nucleic Acids under Molecular Crowding Conditions2012

    • Author(s)
      H.Tateishi-Karimata, T.Endo, N.Isono, Y.Kawasaki, N.Sugimoto
    • Organizer
      Topics related to G-quadruplex and cancer research
    • Place of Presentation
      Taipei, Taiwan(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 産学連携が生みだす企業の異業種への研究展開2011

    • Author(s)
      杉本直己
    • Organizer
      合成部会第2回合成フォーラム
    • Place of Presentation
      甲南大学ポートアイランドキャンパス(兵庫県)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然mRNAのグアニンリッチ配列によるRNA四重鎖構造を介した翻訳伸長反応の抑制2011

    • Author(s)
      川崎悠・遠藤玉樹・杉本直己
    • Organizer
      第6回無細胞生命科学研究会
    • Place of Presentation
      兵庫
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of hydration effect in interaction between DNA G-quadruplex and thrombin2011

    • Author(s)
      S. Nagatoishi, N. Isono and N. Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Hokkaido
    • Related Report
      2011 Final Research Report
  • [Presentation] RNAのhairpin構造形成による転写活性変化2011

    • Author(s)
      小野領也・長門石曉・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      茨城
    • Related Report
      2011 Final Research Report
  • [Presentation] Synchrinized translationによるmRNA構造と翻訳反応の相関評価2011

    • Author(s)
      川崎悠・遠藤玉樹・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      茨城
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of Loop residues of thrombin-binding DNA aptamer on its G-quadruplex stability and thrombin binding2011

    • Author(s)
      S. Nagatoishi, N. Isono, and N. Sugimoto
    • Organizer
      4th European Conference on Chemistry for Life Sciences
    • Place of Presentation
      Hungary
    • Related Report
      2011 Final Research Report
  • [Presentation] Interaction of DNA G-quadruplex with Water, Cations, and its Binding Protein2011

    • Author(s)
      N. Sugimoto
    • Organizer
      The 3rd International Meeting on G-Quadruplex and G-assembly(招待講演)
    • Place of Presentation
      Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Thrombin結合によるDNA四重鎖構造の安定化メカニズムの解明2011

    • Author(s)
      長門石曉・磯野伸・津本浩平・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] mRNAの高次構造が影響する翻訳伸長反応の解析手法の構築2011

    • Author(s)
      川崎悠・遠藤玉樹・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 天然mRNAのグアニンリッチ配列によるRNA四重鎖構造を介した翻訳伸長反応の抑制2011

    • Author(s)
      川崎悠・遠藤玉樹・杉本直己
    • Organizer
      第6回無細胞生命科学研究会
    • Place of Presentation
      兵庫県立大学姫路書写キャンパス(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Formation of DNA G-quadruplex structures in water-in-oil reverse microemulsion2011

    • Author(s)
      S.Pramanik, S.Nagatoishi, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quantitative analyses reveal the unique phenomenon in which A-T base pairs are more stable than G-C base pairs in a hydrated ionic liquid2011

    • Author(s)
      H.Tateishi-Karimata, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] Activity of the hammerhead ribozyme without divalent metal ions but in the presence of neutral additives2011

    • Author(s)
      S.Nakano, Y.Kitagawa, D.Miyoshi, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] Design and selection of artificial RNA switches for construction of intracellular biosensor and gene regulation system2011

    • Author(s)
      T.Endoh, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of noncanonical structure formations in a template DNA on the transcription activity2011

    • Author(s)
      N.Isono, H.Tateishi-Karimata, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] PCR-free detection of telomerase activity in HeLa cells based on catalytic signal amplification with RNaseH2011

    • Author(s)
      H.Yaku, T.Murashima, D.Miyoshi, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of hydration effect in interaction betweenDNA G-quadruplex and thrombin2011

    • Author(s)
      S.Nagatoishi, N.Isono, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] A new fluorescent light-up probe for DNAG-quadruplexes2011

    • Author(s)
      D.Miyoshi, H.Yaku, T.Fujimoto, T.Murashima, N.Sugimoto
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry 2011
    • Place of Presentation
      Clark Hall, Hokkaido University, Hokkaido
    • Related Report
      2011 Annual Research Report
  • [Presentation] TPPリボスイッチを用いた新規アプタマーの合理的設計2011

    • Author(s)
      徳井美里・山内隆寛・三好大輔・西村顕・杉本直己
    • Organizer
      第63回日本生物工学会大会
    • Place of Presentation
      東京農工大学小金井キャンパス(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 擬似細胞核内環境下におけるアニオン性G-quadruplexリガンドのテロメラーゼ阻害効果2011

    • Author(s)
      夜久英信・村嶋貴之・三好大輔・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核酸のヘアピンループ構造形成における熱力学的安定性と水和の相関2011

    • Author(s)
      藤本健史・三好大輔・中野修一・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] RNAのhairpin構造形成による転写活性変化2011

    • Author(s)
      小野領也・長門石暁・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synchrinized translationによるmRNA構造と翻訳反応の相関評価2011

    • Author(s)
      川崎悠・遠藤玉樹・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA-RNAハイブリッド二重鎖の構造柔軟性に関連した水和変化2011

    • Author(s)
      長門石暁・Pramanik Smritimoy・Saxena Sarika・Bhatacharyya Jhimli・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水和イオン液体を用いたDNA二重鎖内におけるワトソン・クリック塩基対の安定性制御2011

    • Author(s)
      建石寿枝・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質-RNA間のアロステリック相互作用を利用した発光バイオセンサーの開発2011

    • Author(s)
      遠藤玉樹・杉本直己
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Toward Development of New Functional Nucleic Acids Working in a Cell2011

    • Author(s)
      N.Sugimoto
    • Organizer
      The 5th Asian Network of Metal Chemistry
    • Place of Presentation
      Bangkok, Thailand(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of Loop residues of thrombin-binding DNA aptamer on its G-quadruplex stability and thrombin binding2011

    • Author(s)
      S.Nagatoishi, N.Isono, N.Sugimoto
    • Organizer
      4th European Conference on Chemistry for Life Sciences
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quantitative analysis of DNA duplex stability in the hydrated ionic liquid of Choline dihydrogenphosphate2011

    • Author(s)
      H.Tateishi-Karimata N.Sugimoto
    • Organizer
      Gordon Research Conference (Nucleosides, Nucleotides & Oligonucleotides)
    • Place of Presentation
      Newport, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Interaction of DNA G-quadruplex with Water, Cations, and its Binding Protein2011

    • Author(s)
      N.Sugimoto
    • Organizer
      The 3rd International Meeting on G-Quadruplex and G-assembly
    • Place of Presentation
      Sorrento, Italy(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quantitative analysis of a DNA duplex stability in a hydrated ionic liquid2011

    • Author(s)
      H.Tateishi-Karimata, N.Sugimoto
    • Organizer
      The 4th Congress on Ionic Liquids (COIL-4)
    • Place of Presentation
      Washington, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Selection of allosteric interaction between RNA and protein for construction of synthetic gene regulation network inside cells2011

    • Author(s)
      T.Endoh, N.Sugimoto
    • Organizer
      The 16th Annual Meeting of the RNA Society
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特別講演会/細胞中の遺伝子制御化学2011

    • Author(s)
      杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] mRNA構造に及ぼす分子クラウディング環境の影響2011

    • Author(s)
      村上健太郎・遠藤玉樹・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞内分子機能スイッチの構築に向けたタンパク質とのアロステリック相互作用を示すRNAのセレクション2011

    • Author(s)
      遠藤玉樹・杉本直己
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA G-quadruplexformation with its binding protein in crowded environment2010

    • Author(s)
      S. Nagatoishi, N. Isono, K. Tsumoto, and N. Sugimoto
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry 2010
    • Place of Presentation
      Yokohama
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質と四重鎖DNAの相互作用における分子クラウディング効果2010

    • Author(s)
      長門石曉・磯野伸・津本浩平・杉本直己
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] mRNAの熱安定性が及ぼす翻訳反応への影響2010

    • Author(s)
      川崎悠・村上健太郎・遠藤玉樹・杉本直己
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] G-quadruplex stability in the presence of its binding protein under a molecular crowding condition2010

    • Author(s)
      S. Nagatoishi, N. Isono, and N. Sugimoto
    • Organizer
      IRT 2010-XIX International Round Table on Nucleosides
    • Place of Presentation
      France
    • Related Report
      2011 Final Research Report
  • [Presentation] RNAサイレンシング関連蛋白質の核酸結合における溶媒効果2010

    • Author(s)
      長門石曉・杉本直己
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Stabilization and Function of Nucleic Acids under Molecular Crowding Conditions2010

    • Author(s)
      N.Sugimoto
    • Organizer
      Symposium on Nucleic Acids Chemistry (Structure and Interactions)
    • Place of Presentation
      Slovenia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characters of Watson-Crick and Hoogsteen Base Pairs Inducing Structural Polymorphism under Molecular Crowding Conditions2010

    • Author(s)
      D.Miyoshi, K.Nakamura, H.Karimata, T.Ohmichi, N.Sugimoto
    • Organizer
      Gordon Research Conference (Biopolymers)
    • Place of Presentation
      USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 核酸化学のニュートレンド2010

    • Author(s)
      杉本直己
    • Organizer
      日本化学会生体機能関連化学部会若手の会 サマースクール2010
    • Place of Presentation
      亀山
    • Related Report
      2010 Annual Research Report
  • [Presentation] G-quadruplex stability in the presence of its binding protein under a molecular crowding condition2010

    • Author(s)
      S.Nagatoishi, N.Isono, N.Sugimoto
    • Organizer
      IRT 2010-XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids Lyon
    • Place of Presentation
      France
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分子クラウディング環境におけるリボスイッチRNAの高次構造安定化に対する熱力学的定量評価2010

    • Author(s)
      遠藤玉樹・村上健太郎・杉本直己
    • Organizer
      第4回バイオ関連化学シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] A New Concept for Design of Functional Nucleic Acids2010

    • Author(s)
      N.Sugimoto
    • Organizer
      International Symposium on Therapeutic Nucleic Acids
    • Place of Presentation
      Poland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Control of gene expression through an allosteric interaction of transactivator prote in and its target RNA2010

    • Author(s)
      T.Endoh, N.Sugimoto
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry 2010
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stabilization of the adenine-specific riboswitch in its ligand binding under molecular crowding condition2010

    • Author(s)
      K.Murakami, T.Endoh, N.Sugimoto
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry 2010
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparative study for the effects of cation and thrombin on the thermal stabilization of G-quadruplex2010

    • Author(s)
      N.Isono, S.Nagatoishi, M.Kudou, K.Tsumoto, N.Sugimoto
    • Organizer
      The 37th International Symposium on Nucleic Acids Chemistry 2010
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Annual Research Report
  • [Book] 核酸化学の定量的基礎と仮説:核酸化学のニュートレンド(CSJカレントビュー)2011

    • Author(s)
      杉本直己
    • Publisher
      化学同人
    • Related Report
      2011 Final Research Report
  • [Book] 核酸化学の定量的基礎と仮説:核酸化学のニュートレンド(CSJカレントビュー)2011

    • Author(s)
      杉本直己
    • Publisher
      化学同人(日本化学会編)
    • Related Report
      2011 Annual Research Report
  • [Book] バイオチップ実用化ハンドブック2010

    • Author(s)
      杉本直己, 中野修一
    • Publisher
      第1章DNAチップの基礎 第1節 ハイブリダイゼーション
    • Related Report
      2010 Annual Research Report
  • [Book] 現代化学,4712010

    • Author(s)
      杉本直己、小林克彰
    • Publisher
      DNAの働きを制御する環境-分子クラウディングによる空間概念-
    • Related Report
      2010 Annual Research Report
  • [Book] 現代化学,4722010

    • Author(s)
      杉本直己、遠藤玉樹
    • Publisher
      タンパク質の合成を制御する環境-分子クラウディングによる時間概念-
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.konan-fiber.jp/activities/search.php

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.konan-fiber.jp/activities/search.php

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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