| Project/Area Number |
22656039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Production engineering/Processing studies
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Arata 首都大学東京, システムデザイン学部, 准教授 (30347273)
TANAKA Yasuhiro 首都大学東京, システムデザイン学部, 特任助教 (80568113)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 微粒子 / 自己整列 / 光学素子 / 蛍光 / 検出感度 / 抗原抗体 / タンパク質 / 物質検出 / ナノ構造 |
|---|
| Research Abstract |
High sensitive matter detection is possible by applying antigen-antibody reaction, one of the biochemical sensing methods. However, fluorescence microscope and/or other analysis equipment are required and the system tends to be complicated. This study aims to simplify such system by combining fluorescent intensity improvement by nano-/microstructuring produced with self-assembly of fine particles on an optical lens and its condensation effect. It was found that the fluorescent intensity was improved up to 6 times compared to a planer substrate without fine structure. However, the improvement is limited by the scattering effect of the fine structure.
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