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Sensitive and selective biochemical sensing with nan-structured surface on an optical element

Research Project

Project/Area Number 22656039
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Production engineering/Processing studies
Research InstitutionTokyo Metropolitan University

Principal Investigator

MORONUKI Nobuyuki  首都大学東京, システムデザイン学部, 教授 (90166463)

Co-Investigator(Kenkyū-buntansha) KANEKO Arata  首都大学東京, システムデザイン学部, 准教授 (30347273)
TANAKA Yasuhiro  首都大学東京, システムデザイン学部, 特任助教 (80568113)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords微粒子 / 自己整列 / 光学素子 / 蛍光 / 検出感度 / 抗原抗体 / タンパク質 / 物質検出 / ナノ構造
Research Abstract

High sensitive matter detection is possible by applying antigen-antibody reaction, one of the biochemical sensing methods. However, fluorescence microscope and/or other analysis equipment are required and the system tends to be complicated. This study aims to simplify such system by combining fluorescent intensity improvement by nano-/microstructuring produced with self-assembly of fine particles on an optical lens and its condensation effect. It was found that the fluorescent intensity was improved up to 6 times compared to a planer substrate without fine structure. However, the improvement is limited by the scattering effect of the fine structure.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Micro-/Nano-structuring based on self-assembly of particles to improve surface functionality in biomedical applications2011

    • Author(s)
      N. Moronuki, M. Nishio, Y. Tanaka
    • Journal Title

      Procedia Engineering

      Volume: 19 Pages: 276-281

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Instability Phenomenon in Dip-Coating Process for Self-Assembly of Fine Particles and Design Countermeasures2011

    • Author(s)
      M. Nishio, N. Moronuki, and A. Kaneko
    • Journal Title

      Int. J. of Automation Technology

      Volume: Vol.5, No.5 Pages: 688-693

    • NAID

      120006514180

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Instability Phenomenon in Dip-Coating Process for Self-Assembly of Fine Particles and Design Countermeasures2011

    • Author(s)
      M.Nishio, N.Moronuki, A.Kaneko
    • Journal Title

      Int.J.of Automation Technology

      Volume: 5 Pages: 688-693

    • NAID

      120006514180

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 光学素子表面に整列させた機能性微粒子による生化学分析の高感度化(第2報)2012

    • Author(s)
      西尾学,諸貫信行,田中靖紘,金子新
    • Organizer
      精密工学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 自己整列微粒子マスクを用いたエッチングによる微細構造の表面積評価2012

    • Author(s)
      欅徳人,諸貫信行
    • Organizer
      日本機械学会関東支部第18期総会講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 光学素子表面に整列させた機能性微粒子による生化学分析の高感度化(第2報)2012

    • Author(s)
      西尾学, 諸貫信行, 田中靖紘, 金子新
    • Organizer
      日本機械学会関東支部第18期総会講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increase in the area of structured surface and its effect on sensitivity improvement of biochemical sensing2011

    • Author(s)
      Y. Tanaka, N. Keyaki, N. Moronuki and A. Kaneko
    • Organizer
      ASPEN2011
    • Place of Presentation
      Hong Kong
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Self-Assembly of functional particles on optical element for sensitivity improvement of biochemical sensor2011

    • Author(s)
      M. Nishio, N. Moronuki, Y. Tanaka, A. Kaneko
    • Organizer
      ASPEN2011
    • Place of Presentation
      Hong Kong
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Self-Assembly of functional particles on optical element for sensitivity improvement of biochemical sensor2011

    • Author(s)
      M.Nishio, N.Moronuki, Y.Tanaka, A.Kaneko
    • Organizer
      Asian Society for Precision Eng.And Nanotechnology
    • Place of Presentation
      Hong Kong
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increase in the area of structured surface and its effect on sensitivity improvement of biochemical sensing2011

    • Author(s)
      Y.Tanaka, N.Keyaki, N.Moronuki, A.Kaneko
    • Organizer
      Asian Society for Precision Eng.And Nanotechnology
    • Place of Presentation
      Hong Kong
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自己整列微粒子マスクを用いた微細エッチング加工特性2011

    • Author(s)
      田中靖紘,諸貫信行,欅徳人
    • Organizer
      砥粒加工学会演論会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己整列微粒子マスクを用いた微細エッチング加工特性2011

    • Author(s)
      田中靖紘, 諸貫信行, 欅徳人
    • Organizer
      砥粒加工学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 表面の微細構造化によるイムノアッセイの高感度化2011

    • Author(s)
      欅徳人,諸貫信行,田中靖紘,西尾学,金子新
    • Organizer
      精密工学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-14
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 光学素子表面に整列させた機能性微粒子による生化学分析の高感度化2011

    • Author(s)
      西尾学,諸貫信行,田中靖紘,金子新
    • Organizer
      精密工学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-14
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Self-assembly of fine particles with dip-coating of colloidal suspension-Effect of zeta potential on the process-2011

    • Author(s)
      Manabu Nishio, N. Moronuki, A. Kaneko, and Y. Tanaka
    • Organizer
      The 6th International Conference on MicroManufacturing
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-03-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Instability Phenomenon in Dip-coating Process for Self-assembly of Fine Particles and Countermeasures with Design, Proc2010

    • Author(s)
      N. Moronuki, M. Nishio, and A. Kaneko
    • Organizer
      14th International Conference on Mechatronics Technology
    • Place of Presentation
      Osaka
    • Year and Date
      2010-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] High Sensitive Biosensing Using Microstructured Surface2010

    • Author(s)
      Y.Tanaka, A.Kaneko, N.Moronuki
    • Organizer
      euspen
    • Place of Presentation
      Delft, Nederland
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Book] 微細構造から考える表面機能2011

    • Author(s)
      諸貫信行
    • Total Pages
      199
    • Publisher
      森北出版
    • Related Report
      2011 Final Research Report
  • [Book] 微細構造から考える表面機能2011

    • Author(s)
      諸貫信行, 他
    • Total Pages
      199
    • Publisher
      森北出版
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.comp.tmu.ac.jp/prost/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.comp.tmu.ac.jp/prost/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.comp.tmu.ac.jp/prost/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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